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PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

Summary[edit | edit source]

  • pan ID?: SAUPAN001398000
  • symbol?:
  • synonym:
  • description?: ATPase

      descriptions from strain specific annotations:

    • ATPase
    • phiPVL ORF41-like protein
    • phage protein
    • RecF/RecN/SMC N terminal domain-containing protein
  • strand?: +
  • coordinates?: 1681636..1683579
  • synteny block?: BlockID0008770
  • occurrence?: in 24% of 34 strains

exo (sbcC) : prophage ssDNA 3'→5' exonuclease [1]

Exonucleases are required to initiate prophage replication. They degrade one strand of linear duplex DNA, providing a 3' single-strand overhang for recombination analogous to lambdaphage recF, recN or redα. Several paralogues exist - this version is SbcC-like but other versions are more redα-like and share a pfam16784 domain. Prophage exonucleases are typically paired with a single-strand DNA recombinase and a single-strand DNA-binding protein.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    JSNZ:
    04-02981:
    08BA02176:
    11819-97:
    6850:
    71193:
    ECT-R 2:
    ED133:
    ED98:
    HO 5096 0412:
    JH1:
    SaurJH1_0328
    JH9:
    SaurJH9_0319
    JKD6008:
    SAA6008_02041
    JKD6159:
    LGA251:
    M013:
    MRSA252:
    MSHR1132:
    MSSA476:
    Mu3:
    Mu50:
    MW2:
    RF122:
    ST398:
    T0131:
    SAT0131_02122
    TCH60:
    TW20:
    SATW20_03390
    USA300_TCH1516:
    USA300HOU_1992
    VC40:

Genome Viewer[edit | edit source]

Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.505)


    Newman          ----MKINKLTISNFAGIKEVTFNFDGKDAKIYGNNATGKTTTATALQWLLFDKGLDGST
    USA300_FPR3757  MRKDMKINKLTISNFAGIKEEKFNFDGKDAKIYGNNATGKTTTATALQWLLFDKGLDGST
                        **************** .**************************************

    Newman          KSFNPVPLNEKNAENYELIPTVFAEFEIDGKITTFKKESHPKYTINQKTNRKEYSRSRTK
    USA300_FPR3757  KSFNPVPLNEKNEENYELIPTVFAEFEIDGKITTFKKESHPKYTINQKTNRKEYSRSRTK
                    ************ ***********************************************

    Newman          KQYINDESIKVKDYKARIDELIDEDVFKLITNPQAFNLLDWKKRRSLLFEIAKPINDEDV
    USA300_FPR3757  KQYINDESIKVKDYKARIDELIDEDVFKLITNPQAFNLLDWKKRRSLLFEIAKPINDEDV
                    ************************************************************

    Newman          IKTNDDFKELNNILGDHEIETKKKILTDKIKQINKDIKDIPIRINQTQQNKQDVPEFDND
    USA300_FPR3757  IKTNDDFKELNNILGDHEIETKKKILTDKIKQINKDIKDIPIRINQTQQNKQDVPEFDND
                    ************************************************************

    Newman          RYAIIKQEIEQLENERIDIQNGKEEINLRNQLADKQSELKRIEDNNSASNENKIHALTNE
    USA300_FPR3757  RYAIIKQEIEQLENERIDIQNGKEEINLRNQLADKQSELKRIEDNNSASNENKIHALTNE
                    ************************************************************

    Newman          LHVENGTVANLKTRLKQNKQQITHEENRRNQLLENHKGLKSDLEKSKNQKFEHLDDNVCS
    USA300_FPR3757  LHVENGTVANLKTRLKQNKQQITHEENRRNQLLENHKGLKSDLEKAKNQKFEYLDDNVCS
                    *********************************************:******:*******

    Newman          CCGQQLPTEQVNEAREKALQKFNVKKSKELETIQTSINHIISEGKKIKPIIEKLEDDNNN
    USA300_FPR3757  CCGQKLPVEQVDMAREKALQKFNASKSKELETIQTSINHIISEGKKIKLIIEKLEDDNNN
                    ****:**.***: **********..*********************** ***********

    Newman          LQIKINEAEERSARIQNKINKLKTTHVDVTQTDEYKAVMLEINEINQKRSNIRKTIQDKV
    USA300_FPR3757  LQIKINEAEERSARIQNKINKLKTTHVDVTQTDEYKAVMLEINEINQKRSNIRKTIQDKV
                    ************************************************************

    Newman          SGIDDKISELTQEKSEIEVSRSIEKSNKHLDDVISELRNEEDRLLDEKEKYSHDLYILKE
    USA300_FPR3757  SGIDDKISELTQEKSEIEVSRSIEKSNKHLDDVISELRNEEDRLLDEKEKYSHDLYILKE
                    ************************************************************

    Newman          FTTTKVKMLTENINNEFDIAEFKLFNTLVNGELEETCSTTVNGVEYDSGLNNASRINVGL
    USA300_FPR3757  FTTTKVKMLTENINNEFEIAEFKLFNTLVNGELEETCSTTVNGVEYDSGLNNASRINVGL
                    *****************:******************************************

    Newman          DIINTLSKHFKVTAPIFIDNAESVTELIKTESQQIQLIVNEQDKKLRMETI
    USA300_FPR3757  DIINTLSKHFKVTAPIFIDNAESVTELIKTESQQIQLIVNEQDKKLRMETI
                    ***************************************************

  1. J P Muyrers, Y Zhang, F Buchholz, A F Stewart
    RecE/RecT and Redalpha/Redbeta initiate double-stranded break repair by specifically interacting with their respective partners.
    Genes Dev: 2000, 14(15);1971-82
    [PubMed:10921910] [WorldCat.org] (P p)
    Lakshminarayan M Iyer, Eugene V Koonin, L Aravind
    Classification and evolutionary history of the single-strand annealing proteins, RecT, Redbeta, ERF and RAD52.
    BMC Genomics: 2002, 3;8
    [PubMed:11914131] [WorldCat.org] [DOI] (P p)
    Simanti Datta, Nina Costantino, Xiaomei Zhou, Donald L Court
    Identification and analysis of recombineering functions from Gram-negative and Gram-positive bacteria and their phages.
    Proc Natl Acad Sci U S A: 2008, 105(5);1626-31
    [PubMed:18230724] [WorldCat.org] [DOI] (I p)
    Maan M Neamah, Ignacio Mir-Sanchis, María López-Sanz, Sonia Acosta, Ignacio Baquedano, Andreas F Haag, Alberto Marina, Silvia Ayora, José R Penadés
    Sak and Sak4 recombinases are required for bacteriophage replication in Staphylococcus aureus.
    Nucleic Acids Res: 2017, 45(11);6507-6519
    [PubMed:28475766] [WorldCat.org] [DOI] (I p)
    Kamil Steczkiewicz, Eric Prestel, Elena Bidnenko, Agnieszka K Szczepankowska
    Expanding Diversity of Firmicutes Single-Strand Annealing Proteins: A Putative Role of Bacteriophage-Host Arms Race.
    Front Microbiol: 2021, 12;644622
    [PubMed:33959107] [WorldCat.org] [DOI] (P e)
    Chrispin Chaguza, Joshua T Smith, Spencer A Bruce, Robert Gibson, Isabella W Martin, Cheryl P Andam
    Prophage-encoded immune evasion factors are critical for Staphylococcus aureus host infection, switching, and adaptation.
    Cell Genom: 2022, 2(11);
    [PubMed:36465278] [WorldCat.org] [DOI] (I p)