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⊟Summary[edit | edit source]
- pan ID?: SAUPAN001823000
- symbol?: —
- synonym:
- description?: phage protein
- strand?: -
- coordinates?: 2271144..2271302
- synteny block?: BlockID0011990
- occurrence?: in 45% of 33 strains
tacL (gpGT) : serogroup A prophage tail assembly chaperone large subunit [1]
Staphylococcal prophages require tail assembly chaperone proteins (TACs) to coat the tape measure protein and prevent asynchronized and unstructured major tail tube protein binding. They will then nucleate major tail tube protein polymerization and be displaced by major tail tube protein subunits in orderly tail tube assembly. This large subunit actually originates from SAUPAN001824000 and is generated via a 3.5% frequency programmed translational frameshift at the G GGA AAG slippery coding sequence. This results in ribosomal slippage to the +3 reading frame and a 182 amino acid protein.
⊟Orthologs[edit | edit source]
04-02981:
—
08BA02176:
C248_0360
11819-97:
MS7_1457
6850:
—
71193:
—
ECT-R 2:
—
ED133:
SAOV_0329
ED98:
SAAV_2021
HO 5096 0412:
SAEMRSA15_13630
JH1:
SaurJH1_1090
JH9:
—
JKD6008:
—
JKD6159:
SAA6159_01367
LGA251:
—
M013:
—
MRSA252:
SAR1508
MSHR1132:
—
MSSA476:
SAS0943
Mu3:
—
Mu50:
—
MW2:
—
RF122:
—
ST398:
SAPIG0384
T0131:
—
TCH60:
HMPREF0772_11701
TW20:
—
USA300_TCH1516:
USA300HOU_1442
VC40:
—
⊟Genome Viewer[edit | edit source]
| COL | |
| NCTC8325 | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MEQYGWTLTEVRKQPYVKLLEILNEENKEETEEKQSEQKVITGTDLRKLFGS
NCTC8325 MEQYGWTLTEVRKQPYVKLLEILNEENKEETEEKQSEQKVITGTDLRKLFGS
USA300_FPR3757 MEQYGWTLTEVRKQPYVKLLEILNEENKEETEEKQSEQKVITGTDLRKLFGS
****************************************************
- ↑ Jun Xu, Roger W Hendrix, Robert L Duda
Conserved translational frameshift in dsDNA bacteriophage tail assembly genes.
Mol Cell: 2004, 16(1);11-21
[PubMed:15469818] [WorldCat.org] [DOI] (P p)Lisa G Pell, Nichole Cumby, Teresa E Clark, Ashleigh Tuite, Kevin P Battaile, Aled M Edwards, Nickolay Y Chirgadze, Alan R Davidson, Karen L Maxwell
A conserved spiral structure for highly diverged phage tail assembly chaperones.
J Mol Biol: 2013, 425(14);2436-49
[PubMed:23542344] [WorldCat.org] [DOI] (I p)