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PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

Summary[edit | edit source]

  • pan ID?: SAUPAN001824000
  • symbol?:
  • synonym:
  • description?: phiSLT ORF116b-like protein

      descriptions from strain specific annotations:

    • phiSLT ORF116b-like protein
    • phage protein
  • strand?: -
  • coordinates?: 2271344..2271694
  • synteny block?: BlockID0012000
  • occurrence?: in 47% of 34 strains

tacS (gpG) : serogroup A prophage tail assembly chaperone small subunit [1]

Staphylococcal prophages require tail assembly chaperone proteins (TACs) to coat the tape measure protein and prevent asynchronized and unstructured major tail tube protein binding. They will then nucleate major tail tube protein polymerization and be displaced by major tail tube protein subunits in orderly tail tube assembly. This small subunit is generated approximately 96.5% of the time - however, at a 3.5% frequency, a programmed translational frameshift at the G GGA AAG slippery coding sequence results in a longer "TacL" product represented by SAUPAN001823000. The balance of these two chaperone lengths allows TACs to properly coat the tape measure protein and prevent binding of both MtpS and MtpL subunits.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    08BA02176:
    C248_0359
    11819-97:
    MS7_1458
    6850:
    71193:
    ECT-R 2:
    ED133:
    ED98:
    SAAV_2022
    HO 5096 0412:
    SAEMRSA15_13640
    JH1:
    SaurJH1_1089
    JH9:
    SaurJH9_1069
    JKD6008:
    JKD6159:
    SAA6159_01368
    JSNZ:
    LGA251:
    M013:
    MRSA252:
    SAR1509
    MSHR1132:
    MSSA476:
    SAS0942
    Mu3:
    Mu50:
    MW2:
    MW1391
    RF122:
    ST398:
    SAPIG0383
    T0131:
    TCH60:
    HMPREF0772_11700
    TW20:
    USA300_TCH1516:
    USA300HOU_1443
    VC40:

Genome Viewer[edit | edit source]

COL
NCTC8325
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MIKFEIKDRKTGKTESYTKEDVTMGEAEKCYEYLELVNQENKKEAPNATKMRQKERQLLV
    NCTC8325        MIKFEIKDRKTGKTESYTKEDVTMGEAEKCYEYLELVNQENKKEAPNATKMRQKERQLLV
    USA300_FPR3757  MIKFEIKDRKTGKTESYTKEDVTMGEAEKCYEYLELVNQENKKEAPNATKMRQKERQLLV
                    ************************************************************

    COL             DLFKDEGLTEEDVLNKMSTKTYTKALQDIFREINGEDEEDSETEPEEMGKTEEQSQ
    NCTC8325        DLFKDEGLTEEDVLNKMSTKTYTKALQDIFREINGEDEEDSETEPEEMGKTEEQSQ
    USA300_FPR3757  DLFKDEGLTEEDVLNKMSTKTYTKALQDIFREINGEDEEDSETEPEEMGKTEEQSQ
                    ********************************************************

  1. Jun Xu, Roger W Hendrix, Robert L Duda
    Conserved translational frameshift in dsDNA bacteriophage tail assembly genes.
    Mol Cell: 2004, 16(1);11-21
    [PubMed:15469818] [WorldCat.org] [DOI] (P p)
    Lisa G Pell, Nichole Cumby, Teresa E Clark, Ashleigh Tuite, Kevin P Battaile, Aled M Edwards, Nickolay Y Chirgadze, Alan R Davidson, Karen L Maxwell
    A conserved spiral structure for highly diverged phage tail assembly chaperones.
    J Mol Biol: 2013, 425(14);2436-49
    [PubMed:23542344] [WorldCat.org] [DOI] (I p)