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⊟Summary[edit | edit source]
- pan ID?: SAUPAN001868000
- symbol?: mepR
- synonym:
- description?: multidrug efflux MATE transporter transcriptional repressor MepR
- multidrug efflux MATE transporter transcriptional repressor MepR
- MarR family transcriptional regulator
- MarR family regulatory protein
- multidrug efflux transporter transcriptional repressor MepR
- transcriptional regulator, MarR family
- marR family protein
- mepA/mepB repressor and autoregulator
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 2363539..2363958
- synteny block?: BlockID0012420
- occurrence?: in 100% of 33 strains
mepR: multidrug efflux pump transcriptional repressor [1]
• A crystal structure is available: 4EM1
• MepR has a consensus DNA binding motif of: 5'-TnRTTAGAnnTCTAAYnA-3'
• The MepR Regulon consists of Two Genes
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0332
08BA02176:
C248_0388
11819-97:
MS7_0323
6850:
RSAU_000279
71193:
ST398NM01_0414
ECT-R 2:
ECTR2_293
ED133:
SAOV_0358
ED98:
SAAV_0301
HO 5096 0412:
SAEMRSA15_02890
JH1:
SaurJH1_0392
JH9:
SaurJH9_0382
JKD6008:
SAA6008_00310 (mepR)
JKD6159:
SAA6159_00308 (mepR)
LGA251:
SARLGA251_02940 (mepR)
M013:
M013TW_0313
MRSA252:
SAR0330
MSHR1132:
SAMSHR1132_03070
MSSA476:
SAS0310
Mu3:
SAHV_0330
Mu50:
SAV0333
MW2:
MW0310
RF122:
SAB0283
ST398:
SAPIG0414
T0131:
SAT0131_00338
TCH60:
HMPREF0772_10162
TW20:
SATW20_04010 (mepR)
USA300_TCH1516:
USA300HOU_0354
VC40:
SAVC_01415
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MEFTYSYLFRMISHEMKQKADQKLEQFDITNEQGHTLGYLYAHQQDGLTQNDIAKALQRT
N315 MEFTYSYLFRMISHEMKQKADQKLEQFDITNEQGHTLGYLYAHQQDGLTQNDIAKALQRT
NCTC8325 MEFTYSYLFRMISHEMKQKADQKLEQFDITNEQGHTLGYLYAHQQDGLTQNDIAKALQRT
Newman MEFTYSYLFRMISHEMKQKADQKLEQFDITNEQGHTLGYLYAHQQDGLTQNDIAKALQRT
USA300_FPR3757 MEFTYSYLFRMISHEMKQKADQKLEQFDITNEQGHTLGYLYAHQQDGLTQNDIAKALQRT
************************************************************
COL GPTVSNLLRNLERKKLIYRYVDAQDTRRKNIGLTTSGIKLVEAFTSIFDEMEQTLVSQLS
N315 GPTVSNLLRNLERKKLIYRYVDAQDTRRKNIGLTTSGIKLVEAFTSIFDEMEQTLVSQLS
NCTC8325 GPTVSNLLRNLERKKLIYRYVDAQDTRRKNIGLTTSGIKLVEAFTSIFDEMEQTLVSQLS
Newman GPTVSNLLRNLERKKLIYRYVDAQDTRRKNIGLTTSGIKLVEAFTSIFDEMEQTLVSQLS
USA300_FPR3757 GPTVSNLLRNLERKKLIYRYVDAQDTRRKNIGLTTSGIKLVEAFTSIFDEMEQTLVSQLS
************************************************************
COL EEENEQMKANLTKMLSSLQ
N315 EEENEQMKANLTKMLSSLQ
NCTC8325 EEENEQMKANLTKMLSSLQ
Newman EEENEQMKANLTKMLSSLQ
USA300_FPR3757 EEENEQMKANLTKMLSSLQ
*******************
- ↑ Muthiah Kumaraswami, Jason T Schuman, Susan M Seo, Glenn W Kaatz, Richard G Brennan
Structural and biochemical characterization of MepR, a multidrug binding transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA.
Nucleic Acids Res: 2009, 37(4);1211-24
[PubMed:19129225] [WorldCat.org] [DOI] (I p)Ivan Birukou, Susan M Seo, Bryan D Schindler, Glenn W Kaatz, Richard G Brennan
Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR.
Nucleic Acids Res: 2014, 42(4);2774-88
[PubMed:24293644] [WorldCat.org] [DOI] (I p)