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Summary[edit | edit source]

  • pan ID?: SAUPAN002104000
  • symbol?: ssl1
  • synonym:
  • description?: staphylococcal superantigen-like protein 1

      descriptions from strain specific annotations:

    • staphylococcal superantigen-like protein 1
    • superantigen-like protein
    • superantigen-like protein SSL1
    • Exotoxin 6
    • exotoxin
    • Staphylococcal enterotoxin-like toxin
    • staphylococcal exotoxin
    • superantigen-like protein 11
  • strand?: +
  • coordinates?: 2587971..2588748
  • synteny block?: BlockID0014100
  • occurrence?: in 100% of 34 strains

ssl1 (set1) : immune evasion serine protease superantigen-like protein SSL1 [1]

The staphylococcal immune evasion superantigen-like proteins are not superantigens but are effective host immune system modulation proteins:

Superantigen-Like Protein Host Target Effect Reference
SSL1 Host interleukins

collagen type I or IV extracellular signal-regulated kinase 2 (hERK2)

matrix metalloproteinases (MMP-8, MMP-9)

cleavage of IL-8, IL-17A and IFN-γ

increased corneal damage and intraocular virulence altered immune cell MAP kinase signaling

reduced neutrophil activation, chemotaxis, and migration

[2]
SSL2
SSL3 TLR2
SSL4
SSL5 C1 inhibitor

matrix metalloproteinases

P-selectin glycoprotein ligand 1

reduced neutrophil activation, chemotaxis, and migration 27399672
SSL6
SSL7 Complement Factor C5

IgA-dependent FcαR1

impaired complement activation

inhibits IgA-FcαRI-activated processes (phagocytosis, degranulation, oxidative boost)

15728504, 23797068
SSL8
SSL9
SSL10 IgG

Complement C1q

CXCR4 receptor

prothrombin, factor Xa

tumor necrosis factor receptor 1 (TNFR1)

impaired IgG-mediated immune response

impaired complement activation

impaired neutrophil trafficking

impaired host blood clotting

necroptosis of host immune cells

[3]
SSL11 sialyllactosamine glycoproteins reduced P-selectin-mediated neutrophil rolling, increased neutrophil adhesion 18045383, 35285627, 30862940
SSL12 unknown mast cell degranulation, pro-inflammatory IL-4, IL-6 and IL-13 production 30795864, 32859377, 35801715
SSL13 formyl peptide receptor 2 (FPR2) neutrophil recruitment, degranulation and oxidative burst 30098280
SSL14 unknown unknown unknown

Orthologs[edit | edit source]

    COL:
    N315:
    SA0382 (set6)
    NCTC8325:
    Newman:
    NWMN_0388 (set1nm)
    USA300_FPR3757:
    04-02981:
    SA2981_0396 (set6)
    08BA02176:
    C248_0472 (set6)
    11819-97:
    MS7_0397
    6850:
    RSAU_000352
    71193:
    ST398NM01_0490
    ECT-R 2:
    ECTR2_357
    ED133:
    SAOV_0440
    ED98:
    SAAV_0365
    HO 5096 0412:
    SAEMRSA15_03530
    JH1:
    SaurJH1_0457
    JH9:
    SaurJH9_0445
    JKD6008:
    SAA6008_00422 (set6)
    JKD6159:
    SAA6159_00375
    JSNZ:
    JSNZ_000354
    LGA251:
    SARLGA251_03600
    M013:
    M013TW_0382
    MRSA252:
    SAR0422
    MSHR1132:
    SAMSHR1132_03720
    MSSA476:
    SAS0384
    Mu3:
    SAHV_0419 (set6)
    Mu50:
    SAV0422 (set6)
    MW2:
    MW0382 (set16)
    RF122:
    SAB0376 (set11)
    ST398:
    SAPIG0490
    T0131:
    SAT0131_00457
    TCH60:
    HMPREF0772_10095
    TW20:
    SATW20_04960
    USA300_TCH1516:
    USA300HOU_0422 (set3)
    VC40:
    SAVC_01735

Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MKFKAIAKASLALGMLATGVITSNVQSVQAKAEVKQQSESELKHYYNKPILERKNVTGFK
    N315            MKFKAIAKASLALGMLATGVITSNVQSVQAKTEVKQQSESELKHYYNKPVLERKNVTGYK
    NCTC8325        MKFKAIAKASLALGMLATGVITSNVQSVQAKAEVKQQSESELKHYYNKPILERKNVTGFK
    Newman          MKFKAIAKASLALGMLATGVITSNVQSVQAKAEVKQQSESELKHYYNKPILERKNVTGFK
    USA300_FPR3757  MKFKAIAKASLALGMLATGVITSNVQSVQAKAEVKQQSESELKHYYNKPILERKNVTGFK
                    *******************************:*****************:********:*

    COL             YTDEGKHYLEVTVGQQHSRITLLGSDKDKFKDGENSNIDVFILREGDSRQATNYSIGGVT
    N315            YTEKGKDYIDVIVDNQYSQISLVGSDKDKFKDGDNSNIDVFILREGDSRQATNYSIGGVT
    NCTC8325        YTDEGKHYLEVTVGQQHSRITLLGSDKDKFKDGENSNIDVFILREGDSRQATNYSIGGVT
    Newman          YTDEGKHYLEVTVGQQHSRITLLGSDKDKFKDGENSNIDVFILREGDSRQATNYSIGGVT
    USA300_FPR3757  YTDEGKHYLEVTVGQQHSRITLLGSDKDKFKDGENSNIDVFILREGDSRQATNYSIGGVT
                    **::**.*::* *.:*:*:*:*:**********:**************************

    COL             KSNSVQYIDYINTPILEIKKDNEDVLKDFYYISKEDISLKELDYRLRERAIKQHGLYSNG
    N315            KTNSQPFIDYIHTPILEIKKGKEEPQSSLYQIYKEDISLKELDYRLRERAIKQHGLYSNG
    NCTC8325        KSNSVQYIDYINTPILEIKKDNEDVLKDFYYISKEDISLKELDYRLRERAIKQHGLYSNG
    Newman          KSNSVQYIDYINTPILEIKKDNEDVLKDFYYISKEDISLKELDYRLRERAIKQHGLYSNG
    USA300_FPR3757  KSNSVQYIDYINTPILEIKKDNEDVLKDFYYISKEDISLKELDYRLRERAIKQHGLYSNG
                    *:**  :****:********.:*:  ..:* * ***************************

    COL             LKQGQITITMNDGTTHTIDLSQKLEKERMGESIDGTKINKILVEMK
    N315            LKQGQITITMKDGKSHTIDLSQKLEKERMGDSIDGRQIQKILVEMK
    NCTC8325        LKQGQITITMNDGTTHTIDLSQKLEKERMGESIDGTKINKILVEMK
    Newman          LKQGQITITMNDGTTHTIDLSQKLEKERMGESIDGTKINKILVEMK
    USA300_FPR3757  LKQGQITITMNDGTTHTIDLSQKLEKERMGESIDGTKINKILVEMK
                    **********:**.:***************:**** :*:*******

  1. John D Fraser, Thomas Proft
    The bacterial superantigen and superantigen-like proteins.
    Immunol Rev: 2008, 225;226-43
    [PubMed:18837785] [WorldCat.org] [DOI] (I p)
  2. Aihua Tang, Armando R Caballero, Michael A Bierdeman, Mary E Marquart, Timothy J Foster, Ian R Monk, Richard J O'Callaghan
    Staphylococcus aureus Superantigen-Like Protein SSL1: A Toxic Protease.
    Pathogens: 2019, 8(1);
    [PubMed:30609641] [WorldCat.org] [DOI] (P e)
    Debabrata Dutta, Devdeep Mukherjee, Indranil Arun Mukherjee, Tapas Kumar Maiti, Amit Basak, Amit Kumar Das
    Staphylococcal superantigen-like proteins interact with human MAP kinase signaling protein ERK2.
    FEBS Lett: 2020, 594(2);266-277
    [PubMed:31468523] [WorldCat.org] [DOI] (I p)
    Kirsten J Koymans, Adinda Bisschop, Mignon M Vughs, Kok P M van Kessel, Carla J C de Haas, Jos A G van Strijp
    Staphylococcal Superantigen-Like Protein 1 and 5 (SSL1 & SSL5) Limit Neutrophil Chemotaxis and Migration through MMP-Inhibition.
    Int J Mol Sci: 2016, 17(7);
    [PubMed:27399672] [WorldCat.org] [DOI] (I e)
  3. Annemiek M E Walenkamp, Ingrid G J Boer, Jovanka Bestebroer, Dennie Rozeveld, Hetty Timmer-Bosscha, Wieger Hemrika, Jos A G van Strijp, Carla J C de Haas
    Staphylococcal superantigen-like 10 inhibits CXCL12-induced human tumor cell migration.
    Neoplasia: 2009, 11(4);333-44
    [PubMed:19308288] [WorldCat.org] [DOI] (I p)
    Saotomo Itoh, Eri Hamada, Go Kamoshida, Ryosuke Yokoyama, Takemasa Takii, Kikuo Onozaki, Tsutomu Tsuji
    Staphylococcal superantigen-like protein 10 (SSL10) binds to human immunoglobulin G (IgG) and inhibits complement activation via the classical pathway.
    Mol Immunol: 2010, 47(4);932-8
    [PubMed:19913916] [WorldCat.org] [DOI] (I p)
    Saotomo Itoh, Ryosuke Yokoyama, Go Kamoshida, Toshinobu Fujiwara, Hiromi Okada, Takemasa Takii, Tsutomu Tsuji, Satoshi Fujii, Hideki Hashizume, Kikuo Onozaki
    Staphylococcal superantigen-like protein 10 (SSL10) inhibits blood coagulation by binding to prothrombin and factor Xa via their γ-carboxyglutamic acid (Gla) domain.
    J Biol Chem: 2013, 288(30);21569-80
    [PubMed:23754290] [WorldCat.org] [DOI] (I p)
    Saotomo Itoh, Takemasa Takii, Kikuo Onozaki, Tsutomu Tsuji, Shigeaki Hida
    Identification of the blood coagulation factor interacting sequences in staphylococcal superantigen-like protein 10.
    Biochem Biophys Res Commun: 2017, 485(1);201-208
    [PubMed:28193526] [WorldCat.org] [DOI] (I p)
    Nan Jia, Guo Li, Xing Wang, Qing Cao, Wanbiao Chen, Chengliang Wang, Ling Chen, Xiaoling Ma, Xuan Zhang, Yue Tao, Jianye Zang, Xi Mo, Jinfeng Hu
    Staphylococcal superantigen-like protein 10 induces necroptosis through TNFR1 activation of RIPK3-dependent signal pathways.
    Commun Biol: 2022, 5(1);813
    [PubMed:35962126] [WorldCat.org] [DOI] (I e)