⊟Summary[edit | edit source]
- pan ID?: SAUPAN002104000
- symbol?: ssl1
- synonym:
- description?: staphylococcal superantigen-like protein 1
- staphylococcal superantigen-like protein 1
- superantigen-like protein
- superantigen-like protein SSL1
- Exotoxin 6
- exotoxin
- Staphylococcal enterotoxin-like toxin
- staphylococcal exotoxin
- superantigen-like protein 11
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 2587971..2588748
- synteny block?: BlockID0014100
- occurrence?: in 100% of 34 strains
ssl1 (set1) : immune evasion serine protease superantigen-like protein SSL1 [1]
The staphylococcal immune evasion superantigen-like proteins are not superantigens but are effective host immune system modulation proteins:
Superantigen-Like Protein | Host Target | Effect | Reference |
---|---|---|---|
SSL1 | Host interleukins
collagen type I or IV extracellular signal-regulated kinase 2 (hERK2) matrix metalloproteinases (MMP-8, MMP-9) |
cleavage of IL-8, IL-17A and IFN-γ
increased corneal damage and intraocular virulence altered immune cell MAP kinase signaling reduced neutrophil activation, chemotaxis, and migration |
[2] |
SSL2 | |||
SSL3 | TLR2 | ||
SSL4 | |||
SSL5 | C1 inhibitor
matrix metalloproteinases P-selectin glycoprotein ligand 1 |
reduced neutrophil activation, chemotaxis, and migration | 27399672 |
SSL6 | |||
SSL7 | Complement Factor C5
IgA-dependent FcαR1 |
impaired complement activation
inhibits IgA-FcαRI-activated processes (phagocytosis, degranulation, oxidative boost) |
15728504, 23797068 |
SSL8 | |||
SSL9 | |||
SSL10 | IgG
Complement C1q CXCR4 receptor prothrombin, factor Xa tumor necrosis factor receptor 1 (TNFR1) |
impaired IgG-mediated immune response
impaired complement activation impaired neutrophil trafficking impaired host blood clotting necroptosis of host immune cells |
[3] |
SSL11 | sialyllactosamine glycoproteins | reduced P-selectin-mediated neutrophil rolling, increased neutrophil adhesion | 18045383, 35285627, 30862940 |
SSL12 | unknown | mast cell degranulation, pro-inflammatory IL-4, IL-6 and IL-13 production | 30795864, 32859377, 35801715 |
SSL13 | formyl peptide receptor 2 (FPR2) | neutrophil recruitment, degranulation and oxidative burst | 30098280 |
SSL14 | unknown | unknown | unknown |
⊟Orthologs[edit | edit source]
⊟Genome Viewer[edit | edit source]
COL | |
N315 | |
NCTC8325 | |
Newman | |
USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKFKAIAKASLALGMLATGVITSNVQSVQAKAEVKQQSESELKHYYNKPILERKNVTGFK
N315 MKFKAIAKASLALGMLATGVITSNVQSVQAKTEVKQQSESELKHYYNKPVLERKNVTGYK
NCTC8325 MKFKAIAKASLALGMLATGVITSNVQSVQAKAEVKQQSESELKHYYNKPILERKNVTGFK
Newman MKFKAIAKASLALGMLATGVITSNVQSVQAKAEVKQQSESELKHYYNKPILERKNVTGFK
USA300_FPR3757 MKFKAIAKASLALGMLATGVITSNVQSVQAKAEVKQQSESELKHYYNKPILERKNVTGFK
*******************************:*****************:********:*
COL YTDEGKHYLEVTVGQQHSRITLLGSDKDKFKDGENSNIDVFILREGDSRQATNYSIGGVT
N315 YTEKGKDYIDVIVDNQYSQISLVGSDKDKFKDGDNSNIDVFILREGDSRQATNYSIGGVT
NCTC8325 YTDEGKHYLEVTVGQQHSRITLLGSDKDKFKDGENSNIDVFILREGDSRQATNYSIGGVT
Newman YTDEGKHYLEVTVGQQHSRITLLGSDKDKFKDGENSNIDVFILREGDSRQATNYSIGGVT
USA300_FPR3757 YTDEGKHYLEVTVGQQHSRITLLGSDKDKFKDGENSNIDVFILREGDSRQATNYSIGGVT
**::**.*::* *.:*:*:*:*:**********:**************************
COL KSNSVQYIDYINTPILEIKKDNEDVLKDFYYISKEDISLKELDYRLRERAIKQHGLYSNG
N315 KTNSQPFIDYIHTPILEIKKGKEEPQSSLYQIYKEDISLKELDYRLRERAIKQHGLYSNG
NCTC8325 KSNSVQYIDYINTPILEIKKDNEDVLKDFYYISKEDISLKELDYRLRERAIKQHGLYSNG
Newman KSNSVQYIDYINTPILEIKKDNEDVLKDFYYISKEDISLKELDYRLRERAIKQHGLYSNG
USA300_FPR3757 KSNSVQYIDYINTPILEIKKDNEDVLKDFYYISKEDISLKELDYRLRERAIKQHGLYSNG
*:** :****:********.:*: ..:* * ***************************
COL LKQGQITITMNDGTTHTIDLSQKLEKERMGESIDGTKINKILVEMK
N315 LKQGQITITMKDGKSHTIDLSQKLEKERMGDSIDGRQIQKILVEMK
NCTC8325 LKQGQITITMNDGTTHTIDLSQKLEKERMGESIDGTKINKILVEMK
Newman LKQGQITITMNDGTTHTIDLSQKLEKERMGESIDGTKINKILVEMK
USA300_FPR3757 LKQGQITITMNDGTTHTIDLSQKLEKERMGESIDGTKINKILVEMK
**********:**.:***************:**** :*:*******
- ↑ John D Fraser, Thomas Proft
The bacterial superantigen and superantigen-like proteins.
Immunol Rev: 2008, 225;226-43
[PubMed:18837785] [WorldCat.org] [DOI] (I p) - ↑ Aihua Tang, Armando R Caballero, Michael A Bierdeman, Mary E Marquart, Timothy J Foster, Ian R Monk, Richard J O'Callaghan
Staphylococcus aureus Superantigen-Like Protein SSL1: A Toxic Protease.
Pathogens: 2019, 8(1);
[PubMed:30609641] [WorldCat.org] [DOI] (P e)Debabrata Dutta, Devdeep Mukherjee, Indranil Arun Mukherjee, Tapas Kumar Maiti, Amit Basak, Amit Kumar Das
Staphylococcal superantigen-like proteins interact with human MAP kinase signaling protein ERK2.
FEBS Lett: 2020, 594(2);266-277
[PubMed:31468523] [WorldCat.org] [DOI] (I p)Kirsten J Koymans, Adinda Bisschop, Mignon M Vughs, Kok P M van Kessel, Carla J C de Haas, Jos A G van Strijp
Staphylococcal Superantigen-Like Protein 1 and 5 (SSL1 & SSL5) Limit Neutrophil Chemotaxis and Migration through MMP-Inhibition.
Int J Mol Sci: 2016, 17(7);
[PubMed:27399672] [WorldCat.org] [DOI] (I e) - ↑ Annemiek M E Walenkamp, Ingrid G J Boer, Jovanka Bestebroer, Dennie Rozeveld, Hetty Timmer-Bosscha, Wieger Hemrika, Jos A G van Strijp, Carla J C de Haas
Staphylococcal superantigen-like 10 inhibits CXCL12-induced human tumor cell migration.
Neoplasia: 2009, 11(4);333-44
[PubMed:19308288] [WorldCat.org] [DOI] (I p)Saotomo Itoh, Eri Hamada, Go Kamoshida, Ryosuke Yokoyama, Takemasa Takii, Kikuo Onozaki, Tsutomu Tsuji
Staphylococcal superantigen-like protein 10 (SSL10) binds to human immunoglobulin G (IgG) and inhibits complement activation via the classical pathway.
Mol Immunol: 2010, 47(4);932-8
[PubMed:19913916] [WorldCat.org] [DOI] (I p)Saotomo Itoh, Ryosuke Yokoyama, Go Kamoshida, Toshinobu Fujiwara, Hiromi Okada, Takemasa Takii, Tsutomu Tsuji, Satoshi Fujii, Hideki Hashizume, Kikuo Onozaki
Staphylococcal superantigen-like protein 10 (SSL10) inhibits blood coagulation by binding to prothrombin and factor Xa via their γ-carboxyglutamic acid (Gla) domain.
J Biol Chem: 2013, 288(30);21569-80
[PubMed:23754290] [WorldCat.org] [DOI] (I p)Saotomo Itoh, Takemasa Takii, Kikuo Onozaki, Tsutomu Tsuji, Shigeaki Hida
Identification of the blood coagulation factor interacting sequences in staphylococcal superantigen-like protein 10.
Biochem Biophys Res Commun: 2017, 485(1);201-208
[PubMed:28193526] [WorldCat.org] [DOI] (I p)Nan Jia, Guo Li, Xing Wang, Qing Cao, Wanbiao Chen, Chengliang Wang, Ling Chen, Xiaoling Ma, Xuan Zhang, Yue Tao, Jianye Zang, Xi Mo, Jinfeng Hu
Staphylococcal superantigen-like protein 10 induces necroptosis through TNFR1 activation of RIPK3-dependent signal pathways.
Commun Biol: 2022, 5(1);813
[PubMed:35962126] [WorldCat.org] [DOI] (I e)