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⊟Summary[edit | edit source]
- pan ID?: SAUPAN002217000
- symbol?: darA
- synonym: pstA
- description?: glutamine synthetase regulatory protein, putative
- glutamine synthetase regulatory protein, putative
- protein from nitrogen regulatory protein P-II (GLNB) family
- protein YaaQ
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 2731362..2731691
- synteny block?: BlockID0015160
- occurrence?: in 100% of 33 strains
pstA (darA): glutamine metabolism operon de-repression protein [1]
When bound to cyclic-di-AMP, disrupts the GlnA-GlnR repressor complex to de-repress the GlnR regulon.
A crystal structure is available at: 4WK3
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0458
08BA02176:
C248_0537
11819-97:
MS7_0460
6850:
RSAU_000420 (yaaQ)
71193:
ST398NM01_0549
ECT-R 2:
ECTR2_423
ED133:
SAOV_0504
ED98:
SAAV_0429
HO 5096 0412:
SAEMRSA15_04090
JH1:
SaurJH1_0517
JH9:
SaurJH9_0504
JKD6008:
SAA6008_00487
JKD6159:
SAA6159_00434
LGA251:
SARLGA251_04170
M013:
M013TW_0452
MRSA252:
SAR0484
MSHR1132:
SAMSHR1132_04270
MSSA476:
SAS0440
Mu3:
SAHV_0480
Mu50:
SAV0483
MW2:
MW0438
RF122:
SAB0432
ST398:
SAPIG0549
T0131:
SAT0131_00526 (ribA)
TCH60:
HMPREF0772_10038
TW20:
SATW20_05510
USA300_TCH1516:
USA300HOU_0482
VC40:
SAVC_02000
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKMIIAIVQDQDSQELADQLVKNNFRATKLATTGGFLRAGNTTFLCGVNDDRVDEILSVI
N315 MKMIIAIVQDQDSQELADQLVKNNFRATKLATTGGFLRAGNTTFLCGVNDDRVDEILSVI
NCTC8325 MKMIIAIVQDQDSQELADQLVKNNFRATKLATTGGFLRAGNTTFLCGVNDDRVDEILSVI
Newman MKMIIAIVQDQDSQELADQLVKNNFRATKLATTGGFLRAGNTTFLCGVNDDRVDEILSVI
USA300_FPR3757 MKMIIAIVQDQDSQELADQLVKNNFRATKLATTGGFLRAGNTTFLCGVNDDRVDEILSVI
************************************************************
COL NQTCGNREQLVSPITPMGGSADSYIPYPVEVEVGGATVFVMPVDAFHQF
N315 NQTCGNREQLVSPITPMGGSADSYIPYPVEVEVGGATVFVMPVDAFHQF
NCTC8325 NQTCGNREQLVSPITPMGGSADSYIPYPVEVEVGGATVFVMPVDAFHQF
Newman NQTCGNREQLVSPITPMGGSADSYIPYPVEVEVGGATVFVMPVDAFHQF
USA300_FPR3757 NQTCGNREQLVSPITPMGGSADSYIPYPVEVEVGGATVFVMPVDAFHQF
*************************************************
- ↑ Ivan Campeotto, Yong Zhang, Miroslav G Mladenov, Paul S Freemont, Angelika Gründling
Complex structure and biochemical characterization of the Staphylococcus aureus cyclic diadenylate monophosphate (c-di-AMP)-binding protein PstA, the founding member of a new signal transduction protein family.
J Biol Chem: 2015, 290(5);2888-901
[PubMed:25505271] [WorldCat.org] [DOI] (I p)