⊟Summary[edit | edit source]

pan ID^?: SAUPAN002340000
symbol^?: —
synonym:
description^?: glycosyl transferase family 1
- glycosyl transferase family 1
- glycosyl transferase, group 1 family protein
- glycosyltransferase
- glycosyl transferase, putative
- poly (glycerol-phosphate) alpha-glucosyltransferase
- putative glycosyl transferase
- glycoside hydrolase family protein
- glycosyl transferase family protein
- glycosyl transferases group 1 family protein
- group 1 glycosyl transferase
strand^?: -
coordinates^?: 2879472..2880965
synteny block^?: BlockID0016390
occurrence^?: in 100% of 33 strains

sdgB : serine-aspartate repeat protein O-glycosyltransferase SdgB ^[1]

• A crystal structure is available: 7EC1

• SdgB can add a single N-acetylglucosamine residue to each aspartate of an SD-repeat. SdgA can extend NAG-primed asparates by an additional N-acetylglucosamine resulting in NAG-NAG disaccharide-modified serine-aspartate repeat proteins.

⊟Orthologs[edit | edit source]

COL:

N315:

NCTC8325:

Newman:

USA300_FPR3757:

04-02981:

SA2981_0542

08BA02176:

C248_0640

11819-97:

MS7_0555

6850:

RSAU_000519

71193:

ST398NM01_0640

ECT-R 2:

ECTR2_519

ED133:

SAOV_0600c

ED98:

SAAV_0528

HO 5096 0412:

SAEMRSA15_04920

JH1:

SaurJH1_0602

JH9:

SaurJH9_0588

JKD6008:

SAA6008_00573

JKD6159:

SAA6159_00519

LGA251:

SARLGA251_05010

M013:

M013TW_0552

MRSA252:

SAR0569

MSHR1132:

SAMSHR1132_05090

MSSA476:

SAS0523

Mu3:

SAHV_0563

Mu50:

SAV0565

MW2:

MW0520

RF122:

SAB0515c

ST398:

SAPIG0640

T0131:

SAT0131_00626

TCH60:

HMPREF0772_12624

TW20:

SATW20_06350

USA300_TCH1516:

USA300HOU_0559

VC40:

SAVC_02415

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

alignment of orthologues:
CLUSTAL format alignment by MAFFT L-INS-i (v7.307)

COL             MNYFVGNSLGVNLTGIEKAIINRLNLFKEMGRPAQCVFLSWNRYLYRNAQNYITSSDYIN
N315            MNYFVGNSLGVNLTGIEKAIINRLNLFKEMGRPAQCVFLSWNRYLYRNAQNYITSSDYIN
NCTC8325        MNYFVGNSLGVNLTGIEKAIINRLNLFKEMGRPAQCVFLSWNRYLYRNAQNYITSSDYIN
Newman          MNYFVGNSLGVNLTGIEKAIINRLNLFKEMGRPAQCVFLSWNRYLYRNAQNYITSSDYIN
USA300_FPR3757  MNYFVGNSLGVNLTGIEKAIINRLNLFKEMGRPAQCVFLSWNRYLYRNAQNYITSSDYIN
                ************************************************************

COL             MYDFFQEATYLERNEPFDWLSYWTDECHYTLKHVENSHDFRIYDQERFLMYAHFQDPKYR
N315            MYDFFQEATYLERNEPFDWLSYWTDECHYTLKHVENSHDFRIYDQERFLMYAHFQDPKYR
NCTC8325        MYDFFQEATYLERNEPFDWLSYWTDECHYTLKHVENSHDFRIYDQERFLMYAHFQDPKYR
Newman          MYDFFQEATYLERNEPFDWLSYWTDECHYTLKHVENSHDFRIYDQERFLMYAHFQDPKYR
USA300_FPR3757  MYDFFQEATYLERNEPFDWLSYWTDECHYTLKHVENSHDFRIYDQERFLMYAHFQDPKYR
                ************************************************************

COL             ILDYVNHFDSQRRKVKRDFYDVRGFLSCSRILVDKQQTLCEFFYNPEGDTKLEKYFSYKD
N315            ILDYVNHFDSQRRKVKRDFYDVRGFLSCSRILVDKQQTLCEFFYNPEGDTKLEKYFSYKD
NCTC8325        ILDYVNHFDSQRRKVKRDFYDVRGFLSCSRILVDKQQTLCEFFYNPEGDTKLEKYFSYKD
Newman          ILDYVNHFDSQRRKVKRDFYDVRGFLSCSRILVDKQQTLCEFFYNPEGDTKLEKYFSYKD
USA300_FPR3757  ILDYVNHFDSQRRKVKRDFYDVRGFLSCSRILVDKQQTLCEFFYNPEGDTKLEKYFSYKD
                ************************************************************

COL             GKPEVQKIIVYYANKQYFFNNETELGAFFIKQLYQHGDLFFSDRNVYTAPIFNLTPESIP
N315            GKPEVQKIIVYYANKQYFFNNETELGAFFIKQLYQHGDLFFSDRNVYTAPIFNLTPESIP
NCTC8325        GKPEVQKIIVYYANKQYFFNNETELGAFFIKQLYQHGDLFFSDRNVYTAPIFNLTPESIP
Newman          GKPEVQKIIVYYANKQYFFNNETELGAFFIKQLYQHGDLFFSDRNVYTAPIFNLTPESIP
USA300_FPR3757  GKPEVQKIIVYYANKQYFFNNETELGAFFIKQLYQHGDLFFSDRNVYTAPIFNLTPESIP
                ************************************************************

COL             VVAVLHSTHIKNIDALDSSPFKNVYKAMFENLSRYRAIIVSTEQQKLDVEKRINHTIPVV
N315            VVAVLHSTHIKNIDALDSSPFKNVYKAMFENLSRYRAIIVSTEQQKLDVEKRINHTIPIV
NCTC8325        VVAVLHSTHIKNIDALDSSPFKNVYKAMFENLSRYRAIIVSTEQQKLDVEKRINHTIPVV
Newman          VVAVLHSTHIKNIDALDSSPFKNVYKAMFENLSRYRAIIVSTEQQKLDVEKRINHTIPVV
USA300_FPR3757  VVAVLHSTHIKNIDALDSSPFKNVYKAMFENLSRYRAIIVSTEQQKLDVEKRINHTIPVV
                **********************************************************:*

COL             NIPVGYSETIDTPVQTLDQRSVKLISVARYSPEKQLHQQIELIKRLVSYVPKIELHMYGF
N315            NIPVGYSETIDTPVQTLDQRSVKLISVARYSPEKQLHQQIELIKRLVSYVPKIELHMYGF
NCTC8325        NIPVGYSETIDTPVQTLDQRSVKLISVARYSPEKQLHQQIELIKRLVSYVPKIELHMYGF
Newman          NIPVGYSETIDTPVQTLDQRSVKLISVARYSPEKQLHQQIELIKRLVSYVPKIELHMYGF
USA300_FPR3757  NIPVGYSETIDTPVQTLDQRSVKLISVARYSPEKQLHQQIELIKRLVSYVPKIELHMYGF
                ************************************************************

COL             GSESKKLNELIQKYGLENHVYLRGFLSNLDQEYSDAYLSLITSNMEGFSLALLESLAHGV
N315            GSESKKLNELIQKYGLENHVYLRGFLSNLNQEYSDAYLSLITSNMEGFSLALLESLAHGV
NCTC8325        GSESKKLNELIQKYGLENHVYLRGFLSNLDQEYSDAYLSLITSNMEGFSLALLESLAHGV
Newman          GSESKKLNELIQKYGLENHVYLRGFLSNLDQEYSDAYLSLITSNMEGFSLALLESLAHGV
USA300_FPR3757  GSESKKLNELIQKYGLENHVYLRGFLSNLDQEYSDAYLSLITSNMEGFSLALLESLAHGV
                *****************************:******************************

COL             PVISYDIKYGPNELITSDFNGYLITKNDEDALFDKVKYVIDHPEVQQRLSKGSLAKAQQY
N315            PVISYDIKYGPNELITPDFNGYLITKNDEDALFDKVKYVIDHPEVQQRLSKGSLAKAQQY
NCTC8325        PVISYDIKYGPNELITSDFNGYLITKNDEDALFDKVKYVIDHPEVQQRLSKGSLAKAQQY
Newman          PVISYDIKYGPNELITSDFNGYLITKNDEDALFDKVKYVIDHPEVQQRLSKGSLAKAQQY
USA300_FPR3757  PVISYDIKYGPNELITSDFNGYLITKNDEDALFDKVKYVIDHPEVQQRLSKGSLAKAQQY
                ****************.*******************************************

COL             SKASLIKQWDQFVRLI
N315            SKASLIKQWDQFVRLI
NCTC8325        SKASLIKQWDQFVRLI
Newman          SKASLIKQWDQFVRLI
USA300_FPR3757  SKASLIKQWDQFVRLI
                ****************

↑ Dong Gyun Kim, Inwha Baek, Yeon Lee, Hyerry Kim, Jin Young Kim, Geul Bang, Sunghwan Kim, Hye Jin Yoon, Byung Woo Han, Se Won Suh, Hyoun Sook Kim
Structural basis for SdgB- and SdgA-mediated glycosylation of staphylococcal adhesive proteins.
Acta Crystallogr D Struct Biol: 2021, 77(Pt 11);1460-1474
[PubMed:34726173] [WorldCat.org] [DOI] (I p)Wouter L W Hazenbos, Kimberly K Kajihara, Richard Vandlen, J Hiroshi Morisaki, Sophie M Lehar, Mark J Kwakkenbos, Tim Beaumont, Arjen Q Bakker, Qui Phung, Lee R Swem, Satish Ramakrishnan, Janice Kim, Min Xu, Ishita M Shah, Binh An Diep, Tao Sai, Andrew Sebrell, Yana Khalfin, Angela Oh, Chris Koth, S Jack Lin, Byoung-Chul Lee, Magnus Strandh, Klaus Koefoed, Peter S Andersen, Hergen Spits, Eric J Brown, Man-Wah Tan, Sanjeev Mariathasan
Novel staphylococcal glycosyltransferases SdgA and SdgB mediate immunogenicity and protection of virulence-associated cell wall proteins.
PLoS Pathog: 2013, 9(10);e1003653
[PubMed:24130480] [WorldCat.org] [DOI] (I p)

[1] Dong Gyun Kim, Inwha Baek, Yeon Lee, Hyerry Kim, Jin Young Kim, Geul Bang, Sunghwan Kim, Hye Jin Yoon, Byung Woo Han, Se Won Suh, Hyoun Sook Kim
Structural basis for SdgB- and SdgA-mediated glycosylation of staphylococcal adhesive proteins.
Acta Crystallogr D Struct Biol: 2021, 77(Pt 11);1460-1474
[PubMed:34726173] [WorldCat.org] [DOI] (I p)Wouter L W Hazenbos, Kimberly K Kajihara, Richard Vandlen, J Hiroshi Morisaki, Sophie M Lehar, Mark J Kwakkenbos, Tim Beaumont, Arjen Q Bakker, Qui Phung, Lee R Swem, Satish Ramakrishnan, Janice Kim, Min Xu, Ishita M Shah, Binh An Diep, Tao Sai, Andrew Sebrell, Yana Khalfin, Angela Oh, Chris Koth, S Jack Lin, Byoung-Chul Lee, Magnus Strandh, Klaus Koefoed, Peter S Andersen, Hergen Spits, Eric J Brown, Man-Wah Tan, Sanjeev Mariathasan
Novel staphylococcal glycosyltransferases SdgA and SdgB mediate immunogenicity and protection of virulence-associated cell wall proteins.
PLoS Pathog: 2013, 9(10);e1003653
[PubMed:24130480] [WorldCat.org] [DOI] (I p)

[1]

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Contents

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

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⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]