From AureoWiki
Jump to navigation Jump to search

Summary[edit | edit source]

  • pan ID?: SAUPAN002490000
  • symbol?: sroB
  • synonym:
  • description?: DUF2922 domain-containing protein

      descriptions from strain specific annotations:

    • DUF2922 domain-containing protein
    • pseudogene
  • strand?: -
  • coordinates?: 3004874..3005098
  • synteny block?: BlockID0017260
  • occurrence?: in 100% of 34 strains

sroB : sigS antisense RNA (s750)-stimulating protein SroB [1]

Staphylococci need to calibrate the levels of their extracytoplasmic function sigma factor SigS in response to environmental signals. One mechanism for posttranscriptional SigS regulation is the SroAB system. As a small operon that is part of the SigS regulon, SroA and SroB bind to and sequester each other, each effectively negating the effect of the other. However, when released, SroA stabilizes sigS mRNA transcripts, ultimately resulting in increased SigS levels whereas free SroB increases expression of s750, a sigS-targeting antisense RNA. How SroB enhances transcription of s750 antisense RNA, how the SroAB complex dissociates and how only one of either the SigS-activating SroA or the SigS-repressing SroB is released in a functional form remains to be defined.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    SA2981_0595
    08BA02176:
    C248_0702
    11819-97:
    MS7_0671
    6850:
    RSAU_000575
    71193:
    ST398NM01_0699
    ECT-R 2:
    ECTR2_571
    ED133:
    SAOV_0655c
    ED98:
    SAAV_0583
    HO 5096 0412:
    SAEMRSA15_05460
    JH1:
    SaurJH1_0657
    JH9:
    SaurJH9_0642
    JKD6008:
    SAA6008_00637
    JKD6159:
    SAA6159_00575
    JSNZ:
    JSNZ_000587
    LGA251:
    SARLGA251_05540
    M013:
    M013TW_0607
    MRSA252:
    SAR0627
    MSHR1132:
    SAMSHR1132_05630
    MSSA476:
    SAS0586
    Mu3:
    SAHV_0616
    Mu50:
    SAV0618
    MW2:
    MW0582
    RF122:
    SAB0571c
    ST398:
    SAPIG0699
    T0131:
    SAT0131_00687
    TCH60:
    HMPREF0772_12568
    TW20:
    SATW20_06950
    USA300_TCH1516:
    USA300HOU_0640
    VC40:
    SAVC_02735

Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             ---------------------------------------MTKTLELSFKSSLDKPVKLQL
    N315            ---------------------------------------MTKTLELSFKSSLDKPVKLQL
    NCTC8325        ---------------------------------------MTKTLELSFKSSLDKPVKLQL
    Newman          MHQTTKLKHSANLLSDLLEKHIAISNSSNLYQFNQEDIFMTKTLELSFKSSLDKPVKLQL
    USA300_FPR3757  ---------------------------------------MTKTLELSFKSSLDKPVKLQL
                                                           *********************

    COL             PQLNNVVTEQVARDSMNALVDLNIIKSNSGTITKVHSAQIIDKTTTVLFEDKK
    N315            PQLNNVVTEQVARDSMNALVDLNIIKSNSGTITKVHSAQIIDKTTTVLFEDKK
    NCTC8325        PQLNNVVTEQVARDSMNALVDLNIIKSNSGTITKVHSAQIIDKTTTVLFEDKK
    Newman          PQLNNVVTEQVARDSMNALVDLNIIKSNSGTITKVHSAQIIDKTTTVLFEDKK
    USA300_FPR3757  PQLNNVVTEQVARDSMNALVDLNIIKSNSGTITKVHSAQIIDKTTTVLFEDKK
                    *****************************************************

  1. Amer Al Ali, Jamilah Alsulami, Joseph I Aubee, Ayotimofe Idowu, Brooke R Tomlinson, Emily A Felton, Jessica K Jackson, Sarah J Kennedy, Nathanial J Torres, Lindsey N Shaw, Karl M Thompson
    Staphylococcus aureus SigS Induces Expression of a Regulatory Protein Pair That Modulates Its mRNA Stability.
    J Bacteriol: 2023, 205(6);e0039222
    [PubMed:37255480] [WorldCat.org] [DOI] (I p)