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Summary[edit | edit source]

  • pan ID?: SAUPAN002491000
  • symbol?: sroA
  • synonym:
  • description?: DUF1659 domain-containing protein
  • strand?: -
  • coordinates?: 3005115..3005318
  • synteny block?: BlockID0017270
  • occurrence?: in 88% of 34 strains

sroA : sigS mRNA-stabilization protein SroA [1]

Staphylococci need to calibrate the levels of their extracytoplasmic function sigma factor SigS in response to environmental signals. One mechanism for posttranscriptional SigS regulation is the SroAB system. As a small operon that is part of the SigS regulon, SroA and SroB bind to and sequester each other, each effectively negating the effect of the other. However, when released, SroA stabilizes sigS mRNA transcripts, ultimately resulting in increased SigS levels whereas free SroB increases expression of s750, a sigS-targeting antisense RNA. How SroB enhances transcription of s750 antisense RNA, how the SroAB complex dissociates and how only one of either the SigS-activating SroA or the SigS-repressing SroB is released in a functional form remains to be defined.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    SA2981_0596
    08BA02176:
    C248_0703
    11819-97:
    MS7_0672
    6850:
    RSAU_000576
    71193:
    ST398NM01_0700
    ECT-R 2:
    ECTR2_572
    ED133:
    SAOV_0656c
    ED98:
    SAAV_0584
    HO 5096 0412:
    SAEMRSA15_05470
    JH1:
    SaurJH1_0658
    JH9:
    SaurJH9_0643
    JKD6008:
    SAA6008_00638
    JKD6159:
    SAA6159_00576
    JSNZ:
    JSNZ_000588
    LGA251:
    SARLGA251_05550
    M013:
    M013TW_0608
    MRSA252:
    SAR0628
    MSHR1132:
    SAMSHR1132_05640
    MSSA476:
    SAS0587
    Mu3:
    SAHV_0617
    Mu50:
    SAV0619
    MW2:
    MW0583
    RF122:
    ST398:
    SAPIG0700
    T0131:
    SAT0131_00688 (uhpT)
    TCH60:
    TW20:
    SATW20_06960
    USA300_TCH1516:
    USA300HOU_0641
    VC40:
    SAVC_02740

Genome Viewer[edit | edit source]

COL
N315
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MSKINHITIVLSFTKVDANGKQTEFKRRFANINPDASNDQIKTFSKLIERLTGETYSNIE
    N315            MSKINHITIVLSFTKVDANGKQTEFKRRFANINPDASNDQIKTFSKLIERLTGETYNNIE
    USA300_FPR3757  MSKINHITIVLSFTKVDANGKQTEFKRRFANINPDASNDQIKTFSKLIERLTGETYSNIE
                    ********************************************************.***

    COL             LIKSLSI
    N315            LIKSLSI
    USA300_FPR3757  LIKSLSI
                    *******

  1. Amer Al Ali, Jamilah Alsulami, Joseph I Aubee, Ayotimofe Idowu, Brooke R Tomlinson, Emily A Felton, Jessica K Jackson, Sarah J Kennedy, Nathanial J Torres, Lindsey N Shaw, Karl M Thompson
    Staphylococcus aureus SigS Induces Expression of a Regulatory Protein Pair That Modulates Its mRNA Stability.
    J Bacteriol: 2023, 205(6);e0039222
    [PubMed:37255480] [WorldCat.org] [DOI] (I p)