⊟Summary[edit | edit source]
- pan ID?: SAUPAN002491000
- symbol?: sroA
- synonym:
- description?: DUF1659 domain-containing protein
- strand?: -
- coordinates?: 3005115..3005318
- synteny block?: BlockID0017270
- occurrence?: in 88% of 34 strains
sroA : sigS mRNA-stabilization protein SroA [1]
Staphylococci need to calibrate the levels of their extracytoplasmic function sigma factor SigS in response to environmental signals. One mechanism for posttranscriptional SigS regulation is the SroAB system. As a small operon that is part of the SigS regulon, SroA and SroB bind to and sequester each other, each effectively negating the effect of the other. However, when released, SroA stabilizes sigS mRNA transcripts, ultimately resulting in increased SigS levels whereas free SroB increases expression of s750, a sigS-targeting antisense RNA. How SroB enhances transcription of s750 antisense RNA, how the SroAB complex dissociates and how only one of either the SigS-activating SroA or the SigS-repressing SroB is released in a functional form remains to be defined.
⊟Orthologs[edit | edit source]
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MSKINHITIVLSFTKVDANGKQTEFKRRFANINPDASNDQIKTFSKLIERLTGETYSNIE
N315 MSKINHITIVLSFTKVDANGKQTEFKRRFANINPDASNDQIKTFSKLIERLTGETYNNIE
USA300_FPR3757 MSKINHITIVLSFTKVDANGKQTEFKRRFANINPDASNDQIKTFSKLIERLTGETYSNIE
********************************************************.***
COL LIKSLSI
N315 LIKSLSI
USA300_FPR3757 LIKSLSI
*******
- ↑ Amer Al Ali, Jamilah Alsulami, Joseph I Aubee, Ayotimofe Idowu, Brooke R Tomlinson, Emily A Felton, Jessica K Jackson, Sarah J Kennedy, Nathanial J Torres, Lindsey N Shaw, Karl M Thompson
Staphylococcus aureus SigS Induces Expression of a Regulatory Protein Pair That Modulates Its mRNA Stability.
J Bacteriol: 2023, 205(6);e0039222
[PubMed:37255480] [WorldCat.org] [DOI] (I p)