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⊟Summary[edit | edit source]

  • pan ID?: SAUPAN003050000
  • symbol?: mnhD1
  • synonym:
  • description?: Na+/H+ antiporter subunit D

      descriptions from strain specific annotations:

    • Na+/H+ antiporter subunit D
    • monovalent cation/H+ antiporter subunit D
    • putative monovalent cation/H+ antiporter subunit D
    • CPA3 family monovalent cation (K+ or Na+):proton (H+) antiporter-3 MnhD subunit
    • CPA3 family monovalent cation:proton (H+) antiporter-3 subunit D
    • monovalent cation antiporter-3 subunit D, MnhD
    • multicomponent K+:H+antiporter family protein
    • Na(+)/H(+) antiporter subunit D
    • Na(+)/H(+) antiporter subunit D (Multiple resistance and pHhomeostasis protein D) (Mrp complex subunit D)
    • Na(+)/H(+) antiporter subunit D1
    • Na(+) H(+) antiporter subunit D
    • Na+/H+ antiporter subunit
    • ShaD
  • strand?: -
  • coordinates?: 3439414..3440910
  • synteny block?: BlockID0021580
  • occurrence?: in 100% of 33 strains

mnhD1 (snoD): sodium/proton antiporter subunit D [1]

• previously annotated as Staphylococcal NADH:ubiquinone oxidoreductase ortholog as it could establish an ion gradient

⊟Orthologs[edit | edit source]

    COL:
    SACOL0952 (mnhD)
    N315:
    SA0810 (mnhD)
    NCTC8325:
    SAOUHSC_00886
    Newman:
    NWMN_0819 (mnhD)
    USA300_FPR3757:
    SAUSA300_0852 (mnhD)
    04-02981:
    SA2981_0904 (mnhD)
    08BA02176:
    C248_0948 (mnhD)
    11819-97:
    MS7_0904 (mrpD)
    6850:
    RSAU_000826 (mnhD2)
    71193:
    ST398NM01_0932
    ECT-R 2:
    ECTR2_805 (phaD)
    ED133:
    SAOV_0895c
    ED98:
    SAAV_0910 (mnhD)
    HO 5096 0412:
    SAEMRSA15_07790 (mnhD)
    JH1:
    SaurJH1_0968
    JH9:
    SaurJH9_0949
    JKD6008:
    SAA6008_00902 (mnhD)
    JKD6159:
    SAA6159_00808 (mnhD)
    LGA251:
    SARLGA251_08670 (mnhD)
    M013:
    M013TW_0868
    MRSA252:
    SAR0911 (mnhD)
    MSHR1132:
    SAMSHR1132_08010
    MSSA476:
    SAS0819
    Mu3:
    SAHV_0944 (mnhD)
    Mu50:
    SAV0949 (mnhD)
    MW2:
    MW0831 (mnhD)
    RF122:
    SAB0816c (mnhD)
    ST398:
    SAPIG0932
    T0131:
    SAT0131_00981
    TCH60:
    HMPREF0772_12298 (mnhD)
    TW20:
    SATW20_09490 (mnhD)
    USA300_TCH1516:
    USA300HOU_0909 (mnhD2)
    VC40:
    SAVC_03920

⊟Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

⊟Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MIESNMLVLTLVIPVITAILLVFIGKRPIIKRYVALGGTLLTLVAAIINLANVVKHGPIR
    N315            MIESNMLVLTLVIPVITAILLVFIGKRPIIKRYVALGGTLLTLVAAIINLANVVKHGPIR
    NCTC8325        MIESNMLVLTLVIPVITAILLVFIGKRPIIKRYVALGGTLLTLVAAIINLANVVKHGPIR
    Newman          MIESNMLVLTLVIPVITAILLVFIGKRPIIKRYVALGGTLLTLVAAIINLANVVKHGPIR
    USA300_FPR3757  MIESNMLVLTLVIPVITAILLVFIGKRPIIKRYVALGGTLLTLVAAIINLANVVKHGPIR
                    ************************************************************

    COL             VELGSWKAPYSIVFVLDIFSALLIITSIIITAIVILYSSQTIGIERERYYYYFSVLFMLI
    N315            VELGSWKAPYSIVFVLDIFSALLIITSIIITAIVILYSYQTIGIERERYYYYFSVLFMLI
    NCTC8325        VELGSWKAPYSIVFVLDIFSALLIITSIIITAIVILYSYQTIGIERERYYYYFSVLFMLI
    Newman          VELGSWKAPYSIVFVLDIFSALLIITSIIITAIVILYSYQTIGIERERYYYYFSVLFMLI
    USA300_FPR3757  VELGSWKAPYSIVFVLDIFSALLIITSIIITAIVILYSYQTIGIERERYYYYFSVLFMLI
                    ************************************** *********************

    COL             GIIGAFTTGDIFNLFVFFEVFLMSSYFLLVIGSTKIQLQETIKYVLVNVVSSSFFVMGVA
    N315            GIIGAFTTGDIFNLFVFFEVFLMSSYFLLVIGSTKIQLQETIKYVLVNVVSSSFFVMGVA
    NCTC8325        GIIGAFTTGDIFNLFVFFEVFLMSSYFLLVIGSTKIQLQETIKYVLVNVVSSSFFVMGVA
    Newman          GIIGAFTTGDIFNLFVFFEVFLMSSYFLLVIGSTKIQLQETIKYVLVNVVSSSFFVMGVA
    USA300_FPR3757  GIIGAFTTGDIFNLFVYFEVFLMSSYFLLVIGSTKIQLQETIKYVLVNVVSSSFFVMGVA
                    ****************:*******************************************

    COL             ILYSVVGTLNLADISNKLANLSAHDSGLVNIVFILFIFVFATKAGVFPMFVWLPSAYYAP
    N315            ILYSVVGTLNLADISNKLANLSAHDSGLVNIVFILFIFVFATKAGVFPMFVWLPSAYYAP
    NCTC8325        ILYSVVGTLNLADISNKLANLSAHDSGLVNIVFILFIFVFATKAGVFPMFVWLPSAYYAP
    Newman          ILYSVVGTLNLADISNKLANLSAHDSGLVNIVFILFIFVFATKAGVFPMFVWLPSAYYAP
    USA300_FPR3757  ILYSVVGTLNLADISNKLANLSAHDSGLVNIVFILFIFVFATKAGVFPMFVWLPSAYYAP
                    ************************************************************

    COL             PIPIIAFFGALLTKVGVYAIARTLSLFFSDNVSFSHYVILFLALLTIIFGCVGAVAYANI
    N315            PIPIIAFFGALLTKVGVYAIARTLSLFFSDNVSFSHYVILFLALLTIIFGCVGAVAYANI
    NCTC8325        PIPIIAFFGALLTKVGVYAIARTLSLFFSDNVSFSHYVILFLALLTIIFGCVGAVAYANI
    Newman          PIPIIAFFGALLTKVGVYAIARTLSLFFSDNVSFSHYVILFLALLTIIFGCVGAVAYANI
    USA300_FPR3757  PIPIIAFFGALLTKVGVYAIARTLSLFFSDNVSFSHYVILFLALLTIIFGCVGAVAYANI
                    ************************************************************

    COL             KKIILYNVMIAVGVILVGVAMMTESGMIGAIYYTLHDMLVKLALFLLIGIMIKITGTADL
    N315            KKIILYNVMIAVGVILVGVAMMTESGMIGAIYYTLHDMLVKLALFLLIGIMIKITGTADL
    NCTC8325        KKIILYNVMIAVGVILVGVAMMTESGMIGAIYYTLHDMLVKLALFLLIGIMIKITGTADL
    Newman          KKIILYNVMIAVGVILVGVAMMTESGMIGAIYYTLHDMLVKLALFLLIGIMIKITGTADL
    USA300_FPR3757  KKIILYNVMIAVGVILVGVAMMTESGMIGAIYYTLHDMLVKLALFLLIGIMIKITGTADL
                    ************************************************************

    COL             RQFGGLIKRYPVLGWSFFIAALSLAGIPPLSGFYGKFFIVQSTFERGFYLSGVIVLLSSL
    N315            RQFGGLIKRYPVLGWSFFIAALSLAGIPPLSGFYGKFFIVQSTFERGFYLSGVIVLLSSL
    NCTC8325        RQFGGLIKRYPVLGWSFFIAALSLAGIPPLSGFYGKFFIVQSTFERGFYLSGVIVLLSSL
    Newman          RQFGGLIKRYPVLGWSFFIAALSLAGIPPLSGFYGKFFIVQSTFERGFYLSGVIVLLSSL
    USA300_FPR3757  RQFGGLIKRYPVLGWSFFIAALSLAGIPPLSGFYGKFFIVQSTFERGFYLSGVIVLLSSL
                    ************************************************************

    COL             VVLYSVIRIFLQGFFGQPKGYDLNNKVDVKYLTTIAIVAVVITVLYGLSADYLYPMVKAG
    N315            VVLYSVIRIFLQGFFGQPKGYDLNNKVDVKYLTTIAIVAVVITVLYGLSADYLYPMVKAG
    NCTC8325        VVLYSVIRIFLQGFFGQPKGYDLNNKVDVKYLTTIAIVAVVITVLYGLSADYLYPMVKAG
    Newman          VVLYSVIRIFLQGFFGQPKGYDLNNKVDVKYLTTIAIVAVVITVLYGLSADYLYPMVKAG
    USA300_FPR3757  VVLYSVIRIFLQGFFGQPKGYDLNNKVDVKYLTTIAIVAVVITVLYGLSADYLYPMVKAG
                    ************************************************************

    COL             AETFYNPSTYVKAVLGGK
    N315            AETFYNPSTYVKAVLGGK
    NCTC8325        AETFYNPSTYVKAVLGGK
    Newman          AETFYNPSTYVKAVLGGK
    USA300_FPR3757  AETFYNPSTYVKAVLGGK
                    ******************

  1. ↑ Arnold S Bayer, Peter McNamara, Michael R Yeaman, Natalie Lucindo, Tiffanny Jones, Ambrose L Cheung, Hans-Georg Sahl, Richard A Proctor
    Transposon disruption of the complex I NADH oxidoreductase gene (snoD) in Staphylococcus aureus is associated with reduced susceptibility to the microbicidal activity of thrombin-induced platelet microbicidal protein 1.
    J Bacteriol: 2006, 188(1);211-22
    [PubMed:16352837] [WorldCat.org] [DOI] (P p)    Manisha Vaish, Alexa Price-Whelan, Tamara Reyes-Robles, Jun Liu, Amyeo Jereen, Stephanie Christie, Francis Alonzo, Meredith A Benson, Victor J Torres, Terry A Krulwich
    Roles of Staphylococcus aureus Mnh1 and Mnh2 Antiporters in Salt Tolerance, Alkali Tolerance, and Pathogenesis.
    J Bacteriol: 2018, 200(5);
    [PubMed:29263099] [WorldCat.org] [DOI] (I e)    Masahiro Ito, Masato Morino, Terry A Krulwich
    Mrp Antiporters Have Important Roles in Diverse Bacteria and Archaea.
    Front Microbiol: 2017, 8;2325
    [PubMed:29218041] [WorldCat.org] [DOI] (P e)
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