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⊟Summary[edit | edit source]
- pan ID?: SAUPAN003124000
- symbol?: —
- synonym:
- description?: MAP domain-containing protein
- MAP domain-containing protein
- truncated MHC class II analog protein
- putative surface protein
- surface protein
- cell surface like-protein Map-w
- extracellular adherence protein Eap
- map-ND2C domain protein
- outer membrane protein
- putative cell surface protein , Map-w-like protein
- surface protein, putative
- truncated cell surface protein map-W
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 3508967..3509401
- synteny block?: BlockID0022160
- occurrence?: in 100% of 34 strains
eapH2 (map-w2) : neutrophil elastase, cathepsin-G, and proteinase-3 inhibitor EapH2 [1]
• A crystal structure is available: 8GDG
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0936
08BA02176:
C248_1004
11819-97:
MS7_0936
6850:
RSAU_000857
71193:
ST398NM01_0977
ECT-R 2:
ECTR2_836
ED133:
SAOV_0927
ED98:
SAAV_0942
HO 5096 0412:
SAEMRSA15_08100
JH1:
SaurJH1_0999
JH9:
SaurJH9_0980
JKD6008:
SAA6008_00934 (eap)
JKD6159:
SAA6159_00837 (eap)
JSNZ:
JSNZ_000941
LGA251:
SARLGA251_08980
M013:
M013TW_0903
MRSA252:
SAR0944
MSHR1132:
SAMSHR1132_08290
MSSA476:
SAS0851
Mu3:
SAHV_0976
Mu50:
SAV0981
MW2:
MW0863
RF122:
SAB0846
ST398:
SAPIG0977
T0131:
SAT0131_01014 (atpF)
TCH60:
HMPREF0772_12264
TW20:
SATW20_09800
USA300_TCH1516:
USA300HOU_0939 (eap)
VC40:
SAVC_04075
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKLKSFITVTLALGMIATTGATVAGNEVSAAEKDKLPATQKAKEMQNVPYTIAVDGIMAF
N315 MKLKSFITVTLALGMIATTGATVTSNEVSAAEKDKLPATQKAKEMQNVPYTIAVDGIMAF
NCTC8325 MKLKSFITVTLALGMIATTGATVAGNEVSAAEKDKLPATQKAKEMQNVPYTIAVDGIMAF
Newman MKLKSFITVTLALGMIATTGATVAGNEVSAAEKDKLPATQKAKEMQNVPYTIAVDGIMAF
USA300_FPR3757 MKLKSFITVTLALGMIATTGATVAGNEVSAAEKDKLPATQKAKEMQNVPYTIAVDGIMAF
***********************:.***********************************
COL NQSYLNLPKDSQLSYLDLGNKVKALLYDERGVTPEKIRNAKSAVYTITWKDGSKKEVDLK
N315 NQSYLNLPKDSQLSYLDLGNKVKALLYDERGVTPEKIRNAKSAVYTITWKDGSKKEVDLK
NCTC8325 NQSYLNLPKDSQLSYLDLGNKVKALLYDERGVTPEKIRNAKSAVYTITWKDGSKKEVDLK
Newman NQSYLNLPKDSQLSYLDLGNKVKALLYDERGVTPEKIRNAKSAVYTITWKDGSKKEVDLK
USA300_FPR3757 NQSYLNLPKDSQLSYLDLGNKVKALLYDERGVTPEKIRNAKSAVYTITWKDGSKKEVDLK
************************************************************
COL KDSYTANLFDSNSIKQIDINVKTK
N315 KDSYTANLFDSNSIKQIDINVKTK
NCTC8325 KDSYTANLFDSNSIKQIDINVKTK
Newman KDSYTANLFDSNSIKQIDINVKTK
USA300_FPR3757 KDSYTANLFDSNSIKQIDINVKTK
************************
- ↑ Daphne A C Stapels, Kasra X Ramyar, Markus Bischoff, Maren von Köckritz-Blickwede, Fin J Milder, Maartje Ruyken, Janina Eisenbeis, William J McWhorter, Mathias Herrmann, Kok P M van Kessel, Brian V Geisbrecht, Suzan H M Rooijakkers
Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors.
Proc Natl Acad Sci U S A: 2014, 111(36);13187-92
[PubMed:25161283] [WorldCat.org] [DOI] (I p)Timothy J Herdendorf, Daphne A C Stapels, Suzan H M Rooijakkers, Brian V Geisbrecht
Local structural plasticity of the Staphylococcus aureus evasion protein EapH1 enables engagement with multiple neutrophil serine proteases.
J Biol Chem: 2020, 295(22);7753-7762
[PubMed:32303641] [WorldCat.org] [DOI] (I p)Nitin Mishra, Timothy J Herdendorf, Om Prakash, Brian V Geisbrecht
Simultaneous inhibition of two neutrophil serine proteases by the S. aureus innate immune evasion protein EapH2.
J Biol Chem: 2023, 299(7);104878
[PubMed:37269950] [WorldCat.org] [DOI] (I p)