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⊟Summary[edit | edit source]
- pan ID?: SAUPAN003831000
- symbol?: sucA
- synonym:
- description?: 2-oxoglutarate dehydrogenase E1 component
- 2-oxoglutarate dehydrogenase E1 component
- 2-oxoglutarate dehydrogenase E1
- 2-oxoglutarate dehydrogenase E1, putative
- oxoglutarate dehydrogenase (succinyl-transferring), E1 component
- oxoglutarate dehydrogenase (succinyl-transferring) E1
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4120528..4123326
- synteny block?: BlockID0028880
- occurrence?: in 100% of 34 strains
sucA (odhA) : 2-oxoglutarate dehydrogenase E1 (decarboxylase) subunit [1]
2-oxoglutarate dehydrogenase (alt: alpha-ketoglutarate dehydrogenase complex, oxoglutarate dehydrogenase) catalyzes a coupled decarboxylation of alpha-ketoglutarate to succinate with thioesterification and transfer of succinate to CoA. The E1 component catalyzes the thiamine-dependent decarboxylation and attaches the succinate product to the lipoamide posttranslational modification of the E2 subunit. The E2 subunit then transfers the succinate from its lipoamide group onto a Coenzyme A resulting in succinyl-CoA.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1367 (odhA)
08BA02176:
C248_1452 (odhA)
11819-97:
MS7_1369 (sucA)
6850:
RSAU_001293 (odhA)
71193:
ST398NM01_1415
ECT-R 2:
ECTR2_1270 (sucA)
ED133:
SAOV_1423c
ED98:
SAAV_1397 (sucA)
HO 5096 0412:
SAEMRSA15_12760 (odhA)
JH1:
SaurJH1_1503 (sucA)
JH9:
SaurJH9_1474 (sucA)
JKD6008:
SAA6008_01379 (kgd)
JKD6159:
SAA6159_01280 (kgd)
JSNZ:
JSNZ_001397
LGA251:
SARLGA251_13300 (odhA)
M013:
M013TW_1358
MRSA252:
SAR1425 (sucA)
MSHR1132:
SAMSHR1132_12540
MSSA476:
SAS1356 (sucA)
Mu3:
SAHV_1401 (sucA)
Mu50:
SAV1413 (sucA)
MW2:
MW1303 (sucA)
RF122:
SAB1269c (sucA)
ST398:
SAPIG1415 (sucA)
T0131:
SAT0131_01491
TCH60:
HMPREF0772_11796 (odhA)
TW20:
SATW20_14140 (odhA)
USA300_TCH1516:
USA300HOU_1348 (sucA)
VC40:
SAVC_06315 (sucA)
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MTNERKEVSEAPVNFGANLGLMLDLYDDFLQDPSSVPEDLQVLFSTIKNDDSIVPALKST
N315 MTNERKEVSEAPVNFGANLGLMLDLYDDFLQDPSSVPEDLQVLFS---------------
NCTC8325 MTNERKEVSEAPVNFGANLGLMLDLYDDFLQDPSSVPEDLQVLFSTIKNDDSIVPALKST
Newman MTNERKEVSEAPVNFGANLGLMLDLYDDFLQDPSSVPEDLQVLFSTIKNDDSIVPALKST
USA300_FPR3757 MTNERKEVSEAPVNFGANLGLMLDLYDDFLQDPSSVPEDLQVLFSTIKNDDSIVPALKST
*********************************************
COL SSQNSDGTIKRVMRLIDNIRQYGHLKADIYPVNPPKRKHVPKLEIEDFDLDQQTLEGISA
N315 -------TIKRVMRLIDNIRQYGHLKADIYPVNPPKRKHVPKLEIEDFDLDQQTLEGISA
NCTC8325 SSQNSDGTIKRVMRLIDNIRQYGHLKADIYPVNPPKRKHVPKLEIEDFDLDQQTLEGISA
Newman SSQNSDGTIKRVMRLIDNIRQYGHLKADIYPVNPPKRKHVPKLEIEDFDLDQQTLEGISA
USA300_FPR3757 SSQNSDGTIKRVMRLIDNIRQYGHLKADIYPVNPPKRKHVPKLEIEDFDLDQQTLEGISA
*****************************************************
COL GIVSDHFADIYDNAYEAILRMEKRYKGPIAFEYTHINNNTERGWLKRRIETPYKVTLNNN
N315 GIVSDHFADIYDNAYEAILRMEKRYKGPIAFEYTHINNNTERGWLKRRIETPYKVTLNNN
NCTC8325 GIVSDHFADIYDNAYEAILRMEKRYKGPIAFEYTHINNNTERGWLKRRIETPYKVTLNNN
Newman GIVSDHFADIYDNAYEAILRMEKRYKGPIAFEYTHINNNTERGWLKRRIETPYKVTLNNN
USA300_FPR3757 GIVSDHFADIYDNAYEAILRMEKRYKGPIAFEYTHINNNTERGWLKRRIETPYKVTLNNN
************************************************************
COL EKRALFKQLAYVEGFEKYLHKNFVGAKRFSIEGVDALVPMLQRTITIAAKEGIKNIQIGM
N315 EKRALFKQLAYVEGFEKYLHKNFVGAKRFSIEGVDALVPMLQRTITIAAKEGIKNIQIGM
NCTC8325 EKRALFKQLAYVEGFEKYLHKNFVGAKRFSIEGVDALVPMLQRTITIAAKEGIKNIQIGM
Newman EKRALFKQLAYVEGFEKYLHKNFVGAKRFSIEGVDALVPMLQRTITIAAKEGIKNIQIGM
USA300_FPR3757 EKRALFKQLAYVEGFEKYLHKNFVGAKRFSIEGVDALVPMLQRTITIAAKEGIKNIQIGM
************************************************************
COL AHRGRLNVLTHVLEKPYEMMISEFMHTDPMKFLPEDGSLQLTAGWTGDVKYHLGGIKTTD
N315 AHRGRLNVLTHVLEKPYEMMISEFMHTDPMKFLPEDGSLQLTAGWTGDVKYHLGGIKTTD
NCTC8325 AHRGRLNVLTHVLEKPYEMMISEFMHTDPMKFLPEDGSLQLTAGWTGDVKYHLGGIKTTD
Newman AHRGRLNVLTHVLEKPYEMMISEFMHTDPMKFLPEDGSLQLTAGWTGDVKYHLGGIKTTD
USA300_FPR3757 AHRGRLNVLTHVLEKPYEMMISEFMHTDPMKFLPEDGSLQLTAGWTGDVKYHLGGIKTTD
************************************************************
COL SYGTMQRIALANNPSHLEIVAPVVEGRTRAAQDDTQRAGAPTTDHHKAMPIIIHGDAAYP
N315 SYGTMQRIALANNPSHLEIVAPVVEGRTRAAQDDTQRAGAPTTDHHKAMPIIIHGDAAYP
NCTC8325 SYGTMQRIALANNPSHLEIVAPVVEGRTRAAQDDTQRAGAPTTDHHKAMPIIIHGDAAYP
Newman SYGTMQRIALANNPSHLEIVAPVVEGRTRAAQDDTQRAGAPTTDHHKAMPIIIHGDAAYP
USA300_FPR3757 SYGTMQRIALANNPSHLEIVAPVVEGRTRAAQDDTQRAGAPTTDHHKAMPIIIHGDAAYP
************************************************************
COL GQGINFETMNLGNLKGYSTGGSLHIITNNRIGFTTEPIDARSTTYSTDVAKGYDVPIFHV
N315 GQGINFETMNLGNLKGYSTGGSLHIITNNRIGFTTEPIDARSTTYSTDVAKGYDVPIFHV
NCTC8325 GQGINFETMNLGNLKGYSTGGSLHIITNNRIGFTTEPIDARSTTYSTDVAKGYDVPIFHV
Newman GQGINFETMNLGNLKGYSTGGSLHIITNNRIGFTTEPIDARSTTYSTDVAKGYDVPIFHV
USA300_FPR3757 GQGINFETMNLGNLKGYSTGGSLHIITNNRIGFTTEPIDARSTTYSTDVAKGYDVPIFHV
************************************************************
COL NADDVEATIEAIDIAMEFRKEFHKDVVIDLVGYRRFGHNEMDEPSITNPVPYQNIRKHDS
N315 NADDVEATIEAIDIAMEFRKEFHKDVVIDLVGYRRFGHNEMDEPSITNPVPYQNIRKHDS
NCTC8325 NADDVEATIEAIDIAMEFRKEFHKDVVIDLVGYRRFGHNEMDEPSITNPVPYQNIRKHDS
Newman NADDVEATIEAIDIAMEFRKEFHKDVVIDLVGYRRFGHNEMDEPSITNPVPYQNIRKHDS
USA300_FPR3757 NADDVEATIEAIDIAMEFRKEFHKDVVIDLVGYRRFGHNEMDEPSITNPVPYQNIRKHDS
************************************************************
COL VEYVFGKKLVNEGVISEDEMHSFIEQVQKELRQAHDKINKADKMDNPDMEKPADLALPLQ
N315 VEYVFGKKLVNEGVISEDEMHSFIEQVQKELRQAHDKINKADKMDNPDMEKPAELALPLQ
NCTC8325 VEYVFGKKLVNEGVISEDEMHSFIEQVQKELRQAHDKINKADKMDNPDMEKPADLALPLQ
Newman VEYVFGKKLVNEGVISEDEMHSFIEQVQKELRQAHDKINKADKMDNPDMEKPADLALPLQ
USA300_FPR3757 VEYVFGKKLVNEGVISEDEMHSFIEQVQKELRQAHDKINKADKMDNPDMEKPADLALPLQ
*****************************************************:******
COL ADEQSFTFDHLKEINDALLTYPDGFNILKKLNKVLEKRHEPFNKEDGLVDWAQAEQLAFA
N315 ADEQSFTFDHLKEINDALLTYPDGFNILKKLNKVLEKRHEPFNKEDGLVDWAQAEQLAFA
NCTC8325 ADEQSFTFDHLKEINDALLTYPDGFNILKKLNKVLEKRHEPFNKEDGLVDWAQAEQLAFA
Newman ADEQSFTFDHLKEINDALLTYPDGFNILKKLNKVLEKRHEPFNKEDGLVDWAQAEQLAFA
USA300_FPR3757 ADEQSFTFDHLKEINDALLTYPDGFNILKKLNKVLEKRHEPFNKEDGLVDWAQAEQLAFA
************************************************************
COL TILQDGTPIRLTGQDSERGTFSHRHAVLHDEQTGETYTPLHHVPDQKATFDIHNSPLSEA
N315 TILQDGTPIRLTGQDSERGTFSHRHAVLHDEQTGETYTPLHHVPDQKATFDIHNSPLSEA
NCTC8325 TILQDGTPIRLTGQDSERGTFSHRHAVLHDEQTGETYTPLHHVPDQKATFDIHNSPLSEA
Newman TILQDGTPIRLTGQDSERGTFSHRHAVLHDEQTGETYTPLHHVPDQKATFDIHNSPLSEA
USA300_FPR3757 TILQDGTPIRLTGQDSERGTFSHRHAVLHDEQTGETYTPLHHVPDQKATFDIHNSPLSEA
************************************************************
COL AVVGFEYGYNVENKKSFNIWEAQYGDFANMSQMIFDNFLFSSRSKWGERSGLTLFLPHAY
N315 AVVGFEYGYNVENKKSFNIWEAQYGDFANMSQMIFDNFLFSSRSKWGERSGLTLFLPHAY
NCTC8325 AVVGFEYGYNVENKKSFNIWEAQYGDFANMSQMIFDNFLFSSRSKWGERSGLTLFLPHAY
Newman AVVGFEYGYNVENKKSFNIWEAQYGDFANMSQMIFDNFLFSSRSKWGERSGLTLFLPHAY
USA300_FPR3757 AVVGFEYGYNVENKKSFNIWEAQYGDFANMSQMIFDNFLFSSRSKWGERSGLTLFLPHAY
************************************************************
COL EGQGPEHSSARLERFLQLAAENNCTVVNLSSSSNYFHLLRAQAASLDSEQMRPLVVMSPK
N315 EGQGPEHSSARLERFLQLAAENNCTVVNLSSSSNYFHLLRAQAASLDSEQMRPLVVMSPK
NCTC8325 EGQGPEHSSARLERFLQLAAENNCTVVNLSSSSNYFHLLRAQAASLDSEQMRPLVVMSPK
Newman EGQGPEHSSARLERFLQLAAENNCTVVNLSSSSNYFHLLRAQAASLDSEQMRPLVVMSPK
USA300_FPR3757 EGQGPEHSSARLERFLQLAAENNCTVVNLSSSSNYFHLLRAQAASLDSEQMRPLVVMSPK
************************************************************
COL SLLRNKTVAKPIDEFTSGGFEPILTESYQADKVTKVILATGKMFIDLKEALAKNPDESVL
N315 SLLRNKTVAKPIDEFTSGGFEPILTESYQADKVTKVILATGKMFIDLKEALAKNPDESVL
NCTC8325 SLLRNKTVAKPIDEFTSGGFEPILTESYQADKVTKVILATGKMFIDLKEALAKNPDESVL
Newman SLLRNKTVAKPIDEFTSGGFEPILTESYQADKVTKVILATGKMFIDLKEALAKNPDESVL
USA300_FPR3757 SLLRNKTVAKPIDEFTSGGFEPILTESYQADKVTKVILATGKMFIDLKEALAKNPDESVL
************************************************************
COL LVAIERLYPFPEEEIEALLAQLPNLEEVSWVQEEPKNQGAWLYVYPYVKVLVADKYDLSY
N315 LVAIERLYPFPEEEIEALLAQLPKLEEVSWVQEEPKNQGAWLYVYPYVKVLVADKYDLSY
NCTC8325 LVAIERLYPFPEEEIEALLAQLPNLEEVSWVQEEPKNQGAWLYVYPYVKVLVADKYDLSY
Newman LVAIERLYPFPEEEIEALLAQLPNLEEVSWVQEEPKNQGAWLYVYPYVKVLVADKYDLSY
USA300_FPR3757 LVAIERLYPFPEEEIEALLAQLPNLEEVSWVQEEPKNQGAWLYVYPYVKVLVADKYDLSY
***********************:************************************
COL HGRIQRAAPAEGDGEIHKLVQNKIIENALKNN
N315 HGRIQRAAPAEGDGEIHKLVQNKIIENALKNN
NCTC8325 HGRIQRAAPAEGDGEIHKLVQNKIIENALKNN
Newman HGRIQRAAPAEGDGEIHKLVQNKIIENALKNN
USA300_FPR3757 HGRIQRAAPAEGDGEIHKLVQNKIIENALKNN
********************************
- ↑ Ying Wang, Martin Saxtorph Bojer, Shilpa Elizabeth George, Zhihao Wang, Peter Ruhdal Jensen, Christiane Wolz, Hanne Ingmer
Inactivation of TCA cycle enhances Staphylococcus aureus persister cell formation in stationary phase.
Sci Rep: 2018, 8(1);10849
[PubMed:30022089] [WorldCat.org] [DOI] (I e)Christopher Campbell, Claire Fingleton, Merve S Zeden, Emilio Bueno, Laura A Gallagher, Dhananjay Shinde, Jongsam Ahn, Heather M Olson, Thomas L Fillmore, Joshua N Adkins, Fareha Razvi, Kenneth W Bayles, Paul D Fey, Vinai C Thomas, Felipe Cava, Geremy C Clair, James P O'Gara
Accumulation of Succinyl Coenzyme A Perturbs the Methicillin-Resistant Staphylococcus aureus (MRSA) Succinylome and Is Associated with Increased Susceptibility to Beta-Lactam Antibiotics.
mBio: 2021, 12(3);e0053021
[PubMed:34182779] [WorldCat.org] [DOI] (I p)Stefano G Giulieri, Romain Guérillot, Sebastian Duchene, Abderrahman Hachani, Diane Daniel, Torsten Seemann, Joshua S Davis, Steven Y C Tong, Bernadette C Young, Daniel J Wilson, Timothy P Stinear, Benjamin P Howden
Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections.
Elife: 2022, 11;
[PubMed:35699423] [WorldCat.org] [DOI] (I e)