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⊟Summary[edit | edit source]
- pan ID?: SAUPAN003944000
- symbol?: bdr
- synonym: ypdA
- description?: thioredoxin reductase
- thioredoxin reductase
- pyridine nucleotide-disulfide oxidoreductase
- bacillithiol system oxidoreductase, YpdA family, putative
- YpdA family putative bacillithiol disulfide reductase
- putative pyridine nucleotide-disulfideoxidoreductase
- FAD-dependent pyridine nucleotide-disulfide oxidoreductase
- FAD-dependent pyridine nucleotide-disulphide oxidoreductase
- pyridine nucleotide-disulfide dehydrogenase
- pyridine nucleotide-disulfide oxidoreductase family protein
- Pyridine oxidoreductase
- thioredoxin reductase-like protein
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4259486..4260472
- synteny block?: BlockID0029900
- occurrence?: in 100% of 33 strains
bdr (ypdA): bacillithiol disulfide reductase [1]
A crystal structure is available: 7A7B
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1436
08BA02176:
C248_1520
11819-97:
MS7_1433
6850:
RSAU_001350
71193:
ST398NM01_1478
ECT-R 2:
ECTR2_1331
ED133:
SAOV_1486
ED98:
SAAV_1466
HO 5096 0412:
SAEMRSA15_13390
JH1:
SaurJH1_1567
JH9:
SaurJH9_1536
JKD6008:
SAA6008_01448
JKD6159:
SAA6159_01343
LGA251:
SARLGA251_13920
M013:
M013TW_1426
MRSA252:
SAR1488
MSHR1132:
SAMSHR1132_13180
MSSA476:
SAS1420
Mu3:
SAHV_1468
Mu50:
SAV1480
MW2:
MW1368
RF122:
SAB1342c
ST398:
SAPIG1478
T0131:
SAT0131_01568
TCH60:
HMPREF0772_11726
TW20:
SATW20_14770
USA300_TCH1516:
USA300HOU_1417
VC40:
SAVC_06645
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MQKVESIIIGGGPCGLSAAIEQKRKGIDTLIIEKGNVVESIYNYPTHQTFFSSSDKLSIG
N315 MQKVESIIIGGGPCGLSAAIEQKRKGIDTLIIEKGNVVESIYNYPTHQTFFSSSDKLSIG
NCTC8325 MQKVESIIIGGGPCGLSAAIEQKRKGIDTLIIEKGNVVESIYNYPTHQTFFSSSDKLSIG
Newman MQKVESIIIGGGPCGLSAAIEQKRKGIDTLIIEKGNVVESIYNYPTHQTFFSSSDKLSIG
USA300_FPR3757 MQKVESIIIGGGPCGLSAAIEQKRKGIDTLIIEKGNVVESIYNYPTHQTFFSSSDKLSIG
************************************************************
COL DVPFIVEESKPRRNQALVYYREVVKHHQLKVNAFEEVLTVKKMNNKFTITTTKDVYECRF
N315 DVPFIVEESKPRRNQALVYYREVVKHHQLKVNAFEEVLTVKKMNNKFTITTTKDVYECRF
NCTC8325 DVPFIVEESKPRRNQALVYYREVVKHHQLKVNAFEEVLTVKKMNNKFTITTTKDVYECRF
Newman DVPFIVEESKPRRNQALVYYREVVKHHQLKVNAFEEVLTVKKMNNKFTITTTKDVYECRF
USA300_FPR3757 DVPFIVEESKPRRNQALVYYREVVKHHQLKVNAFEEVLTVKKMNNKFTITTTKDVYECRF
************************************************************
COL LTIATGYYGQHNTLEVEGADLPKVFHYFKEAHPYFDQDVVIIGGKNSAIDAALELEKAGA
N315 LTIATGYYGQHNTLEVEGADLPKVFHYFKEAHPYFDQDVVIIGGKNSAIDAALELEKAGA
NCTC8325 LTIATGYYGQHNTLEVEGADLPKVFHYFKEAHPYFDQDVVIIGGKNSAIDAALELEKAGA
Newman LTIATGYYGQHNTLEVEGADLPKVFHYFKEAHPYFDQDVVIIGGKNSAIDAALELEKAGA
USA300_FPR3757 LTIATGYYGQHNTLEVEGADLPKVFHYFKEAHPYFDQDVVIIGGKNSAIDAALELEKAGA
************************************************************
COL NVTVLYRGGDYSPSIKPWILPNFTALVNHEKIDMEFNANVTQITEDTVTYEVNGESKTIH
N315 NVTVLYRGGDYSPSIKPWILPNFTALVNHEKIDMEFNANVTQITEDTVTYEVNGESKTIH
NCTC8325 NVTVLYRGGDYSPSIKPWILPNFTALVNHEKIDMEFNANVTQITEDTVTYEVNGESKTIH
Newman NVTVLYRGGDYSPSIKPWILPNFTALVNHEKIDMEFNANVTQITEDTVTYEVNGESKTIH
USA300_FPR3757 NVTVLYRGGDYSPSIKPWILPNFTALVNHEKIDMEFNANVTQITEDTVTYEVNGESKTIH
************************************************************
COL NDYVFAMIGYHPDYEFLKSVGIQINTNEFGTAPMYNKETYETNIENCYIAGVIAAGNDAN
N315 NDYVFAMIGYHPDYEFLKSVGIQINTNEFGTAPMYNKETYETNIENCYIAGVIAAGNDAN
NCTC8325 NDYVFAMIGYHPDYEFLKSVGIQINTNEFGTAPMYNKETYETNIENCYIAGVIAAGNDAN
Newman NDYVFAMIGYHPDYEFLKSVGIQINTNEFGTAPMYNKETYETNIENCYIAGVIAAGNDAN
USA300_FPR3757 NDYVFAMIGYHPDYEFLKSVGIQINTNEFGTAPMYNKETYETNIENCYIAGVIAAGNDAN
************************************************************
COL TIFIENGKFHGGIIAQSMLAKKQTPLES
N315 TIFIENGKFHGGIIAQNMLAKKQTPLES
NCTC8325 TIFIENGKFHGGIIAQSMLAKKQTPLES
Newman TIFIENGKFHGGIIAQSMLAKKQTPLES
USA300_FPR3757 TIFIENGKFHGGIIAQSMLAKKQTPLES
****************.***********
- ↑ Nico Linzner, Vu Van Loi, Verena Nadin Fritsch, Quach Ngoc Tung, Saskia Stenzel, Markus Wirtz, Rüdiger Hell, Chris J Hamilton, Karsten Tedin, Marcus Fulde, Haike Antelmann
Staphylococcus aureus Uses the Bacilliredoxin (BrxAB)/Bacillithiol Disulfide Reductase (YpdA) Redox Pathway to Defend Against Oxidative Stress Under Infections.
Front Microbiol: 2019, 10;1355
[PubMed:31275277] [WorldCat.org] [DOI] (P e)Marta Hammerstad, Ingvild Gudim, Hans-Petter Hersleth
The Crystal Structures of Bacillithiol Disulfide Reductase Bdr (YpdA) Provide Structural and Functional Insight into a New Type of FAD-Containing NADPH-Dependent Oxidoreductase.
Biochemistry: 2020, 59(51);4793-4798
[PubMed:33326741] [WorldCat.org] [DOI] (I p)