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PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40
⊟Summary[edit | edit source]
- pan ID?: SAUPAN004096000
- symbol?: —
- synonym:
- description?: ATPase AAA
- ATPase AAA
- VirB4
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4374650..4378457
- synteny block?: BlockID0031260
- occurrence?: in 24% of 34 strains
virB4 : ICE6013 translocase ATPase VirB4 [1]
Some staphylococci have acquired a Type IV secretion system encoded on an integrative conjugative element (ICE6013), which encodes a minimal conjugative transfer function that may have adapted to double as a small molecule translocation system. Translocase ATPase proteins associate with translocase accessory proteins at the inner leaflet of the cell membrane and are essential for the formation and function of the translocon channel. Their ATP hydrolysis provides the energy to translocate Relaxase and its cargo through the translocon channel. Although these orthologues have not been structurally-confirmed, the entry to the translocon channel typically consists of a hexameric ring of VirB3-VirB4 heterodimers.
⊟Orthologs[edit | edit source]
04-02981:
—
08BA02176:
—
11819-97:
—
6850:
—
71193:
—
ECT-R 2:
—
ED133:
—
ED98:
—
HO 5096 0412:
SAEMRSA15_12320
JH1:
—
JH9:
—
JKD6008:
SAA6008_02636
JKD6159:
—
JSNZ:
—
LGA251:
—
M013:
—
MRSA252:
SAR1293
MSHR1132:
—
MSSA476:
—
Mu3:
—
Mu50:
—
MW2:
—
RF122:
—
ST398:
—
T0131:
SAT0131_02811
TCH60:
—
TW20:
SATW20_27180
USA300_TCH1516:
USA300HOU_0631
VC40:
—
⊟Genome Viewer[edit | edit source]
| COL | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MNLKAPYAGLRDNLLLTKTGEVWAYYRVRSESISTANYDAKEESKKRMRYFLESIKGYQD
USA300_FPR3757 MNLKAPYAGLRDNLLLTKTGEVWAYYRVRSESISTANYDAKEESKKRMRYFLESIKGYQD
************************************************************
COL FHFEMYDHDLDLRNKFKEISKDFDDEAFNVAEYYSKETIDVLEQELQMITHNSFVMGVKI
USA300_FPR3757 FHFEMYDHDLDLRNKFKEISKDFDDEAFNVAEYYSKETIDVLEQELQMITHNSFVMGVKI
************************************************************
COL RELADDAVTLKEILKSTLSDTAERIVSNFGFDVNLDDKILDKYKTFERDLADSFLGIGGE
USA300_FPR3757 RELADDAVTLKEILKSTLSDTAERIVSNFGFDVNLDDKILDKYKTFERDLADSFLGIGGE
************************************************************
COL RLTENELAYIIRKPFISNATHDVQEESSRRAITDIYNAVIDPTRLSVLEVENDNEKFYTT
USA300_FPR3757 RLTENELAYIIRKPFISNATHDVQEESSRRAITDIYNAVIDPTRLSVLEVENDNEKFYTT
************************************************************
COL TVVVDDFPLDMEYTHLFEKAQNMPFPVECHVKAKIINNEKVKKKFDRAKINHKQQAKEKQ
USA300_FPR3757 TVVVDDFPLDMEYTHLFEKAQNMPFPVECHVKAKIINNEKVKKKFDRAKINHKQQAKEKQ
************************************************************
COL DTGDSASEDVQDNLFVLNQMEREVTGSGVFIEWVFMFVIKSDDYRDCKRKAKRLMKRLKE
USA300_FPR3757 DTGDSASEDVQDNLFVLNQMEREVTGSGVFIEWVFMFVIKSDDYRDCKRKAKRLMKRLKE
************************************************************
COL TQIYAVNPLADQLQLFYQCLHGNDLFINKYWLQRTTATGIAENLFGVSQSLGTKTGFYIG
USA300_FPR3757 TQIYAVNPLADQLQLFYQCLHGNDLFINKYWLQRTTATGIAENLFGVSQSLGTKTGFYIG
************************************************************
COL RIDKFIRSVSREEAVASSRDIILFSLLLAAKGIKGAVSDSPHVLITGQTGKGKSFLAKLL
USA300_FPR3757 RIDKFIRSVSREEAVASSRDIILFSLLLAAKGIKGAVSDSPHVLITGQTGKGKSFLAKLL
************************************************************
COL WIYTSFFKGQMLYWDPKSEFAEWFDRVTESKEMQEKYPLFINHLKTFKYVTLNYEDSTNY
USA300_FPR3757 WIYTSFFKGQMLYWDPKSEFAEWFDRVTESKEMQEKYPLFINHLKTFKYVTLNYEDSTNY
************************************************************
COL GCLDPIVFLDGIEANEMLKSVFDEIKSFENYHHIETAIYQAISDTVEERENGKKVGSLNV
USA300_FPR3757 GCLDPIVFLDGIEANEMLKSVFDEIKSFENYHHIETAIYQAISDTVEERENGKKVGSLNV
************************************************************
COL IEKLQNNEDEHVKNAGDLLFEKTQNNILKLVFSDGTNPALNIQEKATILQVKGLDMPKAD
USA300_FPR3757 IEKLQNNEDEHVKNAGDLLFEKTQNNILKLVFSDGTNPALNIQEKATILQVKGLDMPKAD
************************************************************
COL DDTSSYSTSEKNGITLMLLIGKFLEKFGSRRDVQTTIFIDEGWAFSASRQGKKVGKRIKR
USA300_FPR3757 DDTSSYSTSEKNGITLMLLIGKFLEKFGSRRDVQTTIFIDEGWAFSASRQGKKVGKRIKR
************************************************************
COL TGRSENNSLVFITQSVKDKADDDGGNFGCHFAFDEKDEREDILKSLGLEYSKESPENMEM
USA300_FPR3757 TGRSENNSLVFITQSVKDKADDDGGNFGCHFAFDEKDEREDILKSLGLEYSKESPENMEM
************************************************************
COL LKDLKKGQCIFSDFYGRVGKMVVHCPFEEMTEAFRTQEDSASSKAEEKFAM
USA300_FPR3757 LKDLKKGQCIFSDFYGRVGKMVVHCPFEEMTEAFRTQEDSASSKAEEKFAM
***************************************************
- ↑ Zita Nagy, Mónika Szabó, Michael Chandler, Ferenc Olasz
Analysis of the N-terminal DNA binding domain of the IS30 transposase.
Mol Microbiol: 2004, 54(2);478-88
[PubMed:15469518] [WorldCat.org] [DOI] (P p)Davida S Smyth, D Ashley Robinson
Integrative and sequence characteristics of a novel genetic element, ICE6013, in Staphylococcus aureus.
J Bacteriol: 2009, 191(19);5964-75
[PubMed:19648240] [WorldCat.org] [DOI] (I p)Minny Bhatty, Jenny A Laverde Gomez, Peter J Christie
The expanding bacterial type IV secretion lexicon.
Res Microbiol: 2013, 164(6);620-39
[PubMed:23542405] [WorldCat.org] [DOI] (I p)Emily A Sansevere, Xiao Luo, Joo Youn Park, Sunghyun Yoon, Keun Seok Seo, D Ashley Robinson
Transposase-Mediated Excision, Conjugative Transfer, and Diversity of ICE6013 Elements in Staphylococcus aureus.
J Bacteriol: 2017, 199(8);
[PubMed:28138100] [WorldCat.org] [DOI] (I e)