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⊟Summary[edit | edit source]
- pan ID?: SAUPAN004151000
- symbol?: dgkA
- synonym:
- description?: diacylglycerol kinase
- diacylglycerol kinase
- diacylglycerol kinase, putative
- diacylglycerol kinase family protein
- diacylglycerol kinase (DAGK) (Diglyceride kinase)(DGK)
- prokaryotic diacylglycerol kinase family protein
- putative diacylglycerol kinase
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4418838..4419101
- synteny block?: BlockID0031810
- occurrence?: in 100% of 34 strains
dgkA : undecaprenol kinase [1] [2]
In gram-positive bacteria the DgkA kinase is primarily associated with phosphorylation of undecaprenol whereas DgkB is the soluble diacylglycerol kinase. However, DgkA is not essential and other enzymes, potentially, DgkB, can rescue the undecaprenol phosphate requirement in a ΔdgkA mutant strain, albeit with a severe growth defect.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1527
08BA02176:
C248_1612
11819-97:
MS7_1586
6850:
RSAU_001434 (dgkA)
71193:
ST398NM01_1634
ECT-R 2:
ECTR2_1419
ED133:
SAOV_1569
ED98:
SAAV_1561 (dgkA)
HO 5096 0412:
SAEMRSA15_14890
JH1:
SaurJH1_1661
JH9:
SaurJH9_1627
JKD6008:
SAA6008_01539 (dgkA)
JKD6159:
SAA6159_01504 (dgkA)
JSNZ:
JSNZ_001560
LGA251:
SARLGA251_14750
M013:
M013TW_1584
MRSA252:
SAR1646
MSHR1132:
SAMSHR1132_14090
MSSA476:
SAS1507
Mu3:
SAHV_1556
Mu50:
SAV1569
MW2:
MW1521
RF122:
SAB1441c
ST398:
SAPIG1634
T0131:
SAT0131_01665 (hpt)
TCH60:
HMPREF0772_11571 (dgkA)
TW20:
SATW20_15650
USA300_TCH1516:
USA300HOU_1570 (dgkA2)
VC40:
SAVC_07095
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKRFKYALDGLKILIQKDYKFLLHVFAMIVAIVFGLVLNINRIEWIFILIAIALVLTVEA
N315 MKRFKYALDGLKILIQKDYKFLLHVFAMIVAIVFGLVLNINRIEWIFILIAIALVLTVEA
NCTC8325 MKRFKYALDGLKILIQKDYKFLLHVFAMIVAIVFGLVLNINRIEWIFILIAIALVLTVEA
Newman MKRFKYALDGLKILIQKDYKFLLHVFAMIVAIVFGLVLNINRIEWIFILIAIALVLTVEA
USA300_FPR3757 MKRFKYALDGLKILIQKDYKFLLHVFAMIVAIVFGLVLNINRIEWIFILIAIALVLTVEA
************************************************************
COL LNTAIEYVVDLVTVEYHDLAKYAKDIAAFSVLIVSILAFIIGLIVFLPHFIALF
N315 LNTAIEYVVDLVTVEYHDLAKYAKDIAAFSVLIVSILAFIIGLIVFLPHFIALF
NCTC8325 LNTAIEYVVDLVTVEYHDLAKYAKDIAAFSVLIVSILAFIIGLIVFLPHFIALF
Newman LNTAIEYVVDLVTVEYHDLAKYAKDIAAFSVLIVSILAFIIGLIVFLPHFIALF
USA300_FPR3757 LNTAIEYVVDLVTVEYHDLAKYAKDIAAFSVLIVSILAFIIGLIVFLPHFIALF
******************************************************
- ↑ Naoki Kawakami, Kasumi Shimada, Takaaki Fujita, Izumo Kanesaka, Intetsu Kobayashi, Shingo Fujisaki, Construction of Staphylococcus aureus Mutant Deficient in the Undecaprenol Kinase Gene, dgkA, and Elucidation of the Role of Undecaprenol Kinase in the Metabolism of Undecaprenyl Phosphate, Journal of Biological Macromolecules, 2018, Volume 18, Issue 3, Pages 51-58, https://doi.org/10.14533/jbm.18.51
- ↑ Wade D Van Horn, Charles R Sanders
Prokaryotic diacylglycerol kinase and undecaprenol kinase.
Annu Rev Biophys: 2012, 41;81-101
[PubMed:22224599] [WorldCat.org] [DOI] (I p)Naoki Kawakami, Shingo Fujisaki
Undecaprenyl phosphate metabolism in Gram-negative and Gram-positive bacteria.
Biosci Biotechnol Biochem: 2018, 82(6);940-946
[PubMed:29198165] [WorldCat.org] [DOI] (I p)