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⊟Summary[edit | edit source]
- pan ID?: SAUPAN004288000
- symbol?: engB
- synonym:
- description?: ribosome biogenesis GTP-binding protein YsxC
- ribosome biogenesis GTP-binding protein YsxC
- GTP-binding protein
- GTP-binding protein engB
- YihA family ribosome biogenesis GTP-binding protein
- probable GTP-binding protein EngB
- putative GTP-binding protein
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4532561..4533151
- synteny block?: BlockID0033120
- occurrence?: in 100% of 33 strains
engB (ysxC): 50S ribosome stability protein and ribosome-associated GTPase [1]
A crystal structures is available: 8QUA
Ribosome-associated GTPases including Era, RsgA, RbgA, HflX, ObgE, EngA and EngB are widely-conserved, stringent response alarmone-responsive ribosomal assembly cofactors
• EngB is thought to associate primarily with the 50S ribosome although the mechanism is not well understood. Alarmone binding may alter binding affinity to RplQ, RpsB and RpsJ.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1633 (engB)
08BA02176:
C248_1714
11819-97:
MS7_1681 (ysxC)
6850:
RSAU_001532 (engB)
71193:
ST398NM01_1728
ECT-R 2:
ECTR2_1514
ED133:
SAOV_1662
ED98:
SAAV_1660 (engB)
HO 5096 0412:
SAEMRSA15_15840
JH1:
SaurJH1_1765 (engB)
JH9:
SaurJH9_1731 (engB)
JKD6008:
SAA6008_01641 (engB)
JKD6159:
SAA6159_01598 (engB)
LGA251:
SARLGA251_15660
M013:
M013TW_1687
MRSA252:
SAR1753 (engB)
MSHR1132:
SAMSHR1132_15010
MSSA476:
SAS1602 (engB)
Mu3:
SAHV_1660 (engB)
Mu50:
SAV1673 (engB)
MW2:
MW1617 (engB)
RF122:
SAB1533c (engB)
ST398:
SAPIG1728
T0131:
SAT0131_01775
TCH60:
HMPREF0772_11477 (ysxC)
TW20:
SATW20_16640
USA300_TCH1516:
USA300HOU_1665 (engB)
VC40:
SAVC_07575 (engB)
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKVNPNNIELIISAVKEEQYPETELSEVALSGRSNVGKSTFINSMIGRKNMARTSQQPGK
N315 MKVNPNNIELIISAVKEEQYPETELSEVALSGRSNVGKSTFINSMIGRKNMARTSQQPGK
NCTC8325 MKVNPNNIELIISAVKEEQYPETELSEVALSGRSNVGKSTFINSMIGRKNMARTSQQPGK
Newman MKVNPNNIELIISAVKEEQYPETELSEVALSGRSNVGKSTFINSMIGRKNMARTSQQPGK
USA300_FPR3757 MKVNPNNIELIISAVKEEQYPETELSEVALSGRSNVGKSTFINSMIGRKNMARTSQQPGK
************************************************************
COL TQTLNFYNIDEQLIFVDVPGYGYAKVSKTQREKFGKMIEEYITKRENLQLVIQLVDLRHD
N315 TQTLNFYNIDEQLIFVDVPGYGYAKVSKTQREKFGKMIEEYITKRENLQLVIQLVDLRHD
NCTC8325 TQTLNFYNIDEQLIFVDVPGYGYAKVSKTQREKFGKMIEEYITKRENLQLVIQLVDLRHD
Newman TQTLNFYNIDEQLIFVDVPGYGYAKVSKTQREKFGKMIEEYITKRENLQLVIQLVDLRHD
USA300_FPR3757 TQTLNFYNIDEQLIFVDVPGYGYAKVSKTQREKFGKMIEEYITKRENLQLVIQLVDLRHD
************************************************************
COL PTQDDILMYNYLKHFDIPTLVICTKEDKIPKGKVQKHIKNIKTQLDMDPDDTIVSYSSIQ
N315 PTQDDILMYNYLKHFDIPTLVICTKEDKIPKGKVQKHIKNIKTQLDMDPDDTIVSYSSIQ
NCTC8325 PTQDDILMYNYLKHFDIPTLVICTKEDKIPKGKVQKHIKNIKTQLDMDPDDTIVSYSSIQ
Newman PTQDDILMYNYLKHFDIPTLVICTKEDKIPKGKVQKHIKNIKTQLDMDPDDTIVSYSSIQ
USA300_FPR3757 PTQDDILMYNYLKHFDIPTLVICTKEDKIPKGKVQKHIKNIKTQLDMDPDDTIVSYSSIQ
************************************************************
COL NNKQQQIWNLIEPYIS
N315 NNKQQQIWNLIEPYIS
NCTC8325 NNKQQQIWNLIEPYIS
Newman NNKQQQIWNLIEPYIS
USA300_FPR3757 NNKQQQIWNLIEPYIS
****************
- ↑ Elizabeth L Cooper, Jorge García-Lara, Simon J Foster
YsxC, an essential protein in Staphylococcus aureus crucial for ribosome assembly/stability.
BMC Microbiol: 2009, 9;266
[PubMed:20021644] [WorldCat.org] [DOI] (I e)Amit Goyal, Kannan Muthu, Manivel Panneerselvam, Anil Kumar Pole, Krishna Ramadas
Molecular dynamics simulation of the Staphylococcus aureus YsxC protein: molecular insights into ribosome assembly and allosteric inhibition of the protein.
J Mol Model: 2011, 17(12);3129-49
[PubMed:21360172] [WorldCat.org] [DOI] (I p)Artem Biktimirov, Daut Islamov, Bulat Fatkhullin, Vladimir Lazarenko, Shamil Validov, Marat Yusupov, Konstantin Usachev
Crystal structure of GTPase YsxC from Staphylococcus aureus.
Biochem Biophys Res Commun: 2024, 699;149545
[PubMed:38277729] [WorldCat.org] [DOI] (I p)