PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

⊟Summary

• pan ID^?: SAUPAN004550000
• symbol^?: hsdS2
• synonym:
• description^?: specificity determinant HsdS

  descriptions from strain specific annotations:

  • specificity determinant HsdS
  • type I restriction-modification enzyme, S subunit
  • type I restriction-modification enzyme, S subunit, EcoA family protein
  • type I restriction modification system, site specificity determination subunit
  • type I restriction-modification system subunit S
  • pseudogene
  • restriction modification DNA specificity protein
  • restriction modification system DNA specificity subunit
  • type I restriction modification DNA specificity domain protein
  • Type I restriction-modification system, specificity subunit S
  • type I restriction-modification system specificity protein
  • type I site-specific deoxyribonuclease specificity subunit
• strand^?: -
• coordinates^?: 4771132..4780171
• synteny block^?: BlockID0035400
• occurrence^?: in 58% of 33 strains

⊟Orthologs

COL:
SACOL1861 (hsdS)
N315:
SA1625
NCTC8325:
SAOUHSC_01932
Newman:
NWMN_1699 (hsdS)
USA300_FPR3757:
SAUSA300_1751 (hsdS)
04-02981:
SA2981_1762
08BA02176:
—
11819-97:
—
6850:
—
71193:
—
ECT-R 2:
ECTR2_1640
ED133:
—
ED98:
SAAV_1815 (hsdS)
HO 5096 0412:
—
JH1:
SaurJH1_1894
JH9:
SaurJH9_1859
JKD6008:
—
JKD6159:
—
LGA251:
—
M013:
—
MRSA252:
—
MSHR1132:
—
MSSA476:
SAS1731
Mu3:
SAHV_1792
Mu50:
SAV1807
MW2:
MW1750 (hsdS)
RF122:
SAB1667c
ST398:
—
T0131:
SAT0131_01927
TCH60:
—
TW20:
SATW20_18040
USA300_TCH1516:
USA300HOU_1799 (hsdS2)
VC40:
SAVC_08270

⊟Genome Viewer

COL
N315
NCTC8325
Newman
USA300_FPR3757

⊟Alignments

• alignment of orthologues:
  CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
  
  
  COL             MSNTQKKNVPELRFPGFEGEWEEKKLGNLTTKIGSGKTPKGGSENYTNKGIPFLRSQNIR
  N315            MSNTQTKNVPELRFPGFEGEWEEKKLGNLTTKIGSGKTPKGGSENYTNKGIPFLRSQNIR
  NCTC8325        MSNTQTKNVPELRFPGFEGEWEEKKLGNLTTKIGSGKTPKGGSENYTNKGIPFLRSQNIR
  Newman          MSNTQKKNVPELRFPGFEGEWEEKKLGNLTTKIGSGKTPKGGSENYTNKGIPFLRSQNIR
  USA300_FPR3757  MSNTQKKNVPELRFPGFEGEWEEKKLGNLTTKIGSGKTPKGGSENYTNKGIPFLRSQNIR
                  *****.******************************************************
  
  COL             NGKLNLNDLVYISKDIDDEMKNSRTYYGDVLLNITGASIGRTAINSIVETHANLNQHVCI
  N315            NGKLNLNDLVYISKDIDDEMKNSRTYYGDVLLNITGASIGRTAINSIVETHANLNQHVCI
  NCTC8325        NGKLNLNDLVYISKDIDDEMKNSRTYYGDVLLNITGASIGRTAINSIVETHANLNQHVCI
  Newman          NGKLNLNDLVYISKDIDDEMKNSRTYYGDVLLNITGASIGRTAINSIVETHANLNQHVCI
  USA300_FPR3757  NGKLNLNDLVYISKDIDDEMKNSRTYYGDVLLNITGASIGRTAINSIVETHANLNQHVCI
                  ************************************************************
  
  COL             IRLKKEYYYNFFGQYLLSRKGKRKIFLAQSGGSREGLNFKEIANLKIFTPTIFEEQQKIG
  N315            IRLKKEYYYNFFGQYLLSRKGKRKIFLAQSGGSREGLNFKEIANLKIFTPTIFEEQQKIG
  NCTC8325        IRLKKEYYYNFFGQYLLSRKGKRKIFLAQSGGSREGLNFKEIANLKIFTPTIFEEQQKIG
  Newman          IRLKKEYYYNFFGQYLLSRKGKRKIFLAQSGGSREGLNFKEIANLKIFTPTIFEEQQKIG
  USA300_FPR3757  IRLKKEYYYNFFGQYLLSRKGKRKIFLAQSGGSREGLNFKEIANLKIFTPTIFEEQQKIG
                  ************************************************************
  
  COL             KFFSKLDRQIELEEQKLELLQQQKKGYMQKIFTQELRFKDENGEEYPEWENKFIKDIFIF
  N315            QFFSKLDQQIELEEQKLELLQQQKKCYIQKIFSQELRFKDEEGNYYKGWNKKQLKDVLEF
  NCTC8325        KFFSKLDRQIELEEQKLELLQQQKKGYMQKIFTQELRFKDENGEEYPEWENKFIKDIFIF
  Newman          KFFSKLDRQIELEEQKLELLQQQKKGYMQKIFTQELRFKDENGEEYPEWENKFIKDIFIF
  USA300_FPR3757  KFFSKLDRQIELEEQKLELLQQQKKGYMQKIFTQELRFKDENGEEYPEWENKFIKDIFIF
                  :******:***************** *:****:********:*: *  *::* :**:: *
  
  COL             ENNR-----RKPITSSLREKGLYPYYGATGIIDYVKDYLFNNEERL---------LIGED
  N315            SNKRTINENEYPVLTSSRQ-------GLILQSDYYKDRKTFAESNIGYFILPKNHITYRS
  NCTC8325        ENNR-----RKPITSSLREKGLYPYYGATGIIDYVKDYLFNNEERL---------LIGED
  Newman          ENNR-----RKPITSSLREKGLYPYYGATGIIDYVKDYLFNNEERL---------LIGED
  USA300_FPR3757  ENNR-----RKPITSSLREKGLYPYYGATGIIDYVKDYLFNNEERL---------LIGED
                  .*:*     . *: :* *:       *     ** **     *..:         :  ..
  
  COL             GAKWGQFETSSFIANGQYWVNNHAHVVKSNDHNLFFMNYYLNF---KELRAFVTGNAPAK
  N315            RSDDGIFKFNLNLMIDVGIISKYYPVFKGIDANQYYLTLHLNYQLKKEYIKYATGTSQLV
  NCTC8325        GAKWGQFETSSFIANGQYWVNNHAHVVKSNDHNLFFMNYYLNF---KELRAFVTGNAPAK
  Newman          GAKWGQFETSSFIANGQYWVNNHAHVVKSNDHNLFFMNYYLNF---KELRAFVTGNAPAK
  USA300_FPR3757  GAKWGQFETSSFIANGQYWVNNHAHVVKSNDHNLFFMNYYLNF---KELRAFVTGNAPAK
                   :. * *: .  :  .   :.::  *.*. * * :::. :**:   **   :.**.:   
  
  COL             LTHANLCNINLKIPCLTEQDKVSALLKSIDNKMNNQMNRIELLKERKKGLLQKMFI
  N315            LSQKDLQNIKTKLPSYEEQQKIGDFFSEIDRLVEKQSSKVGRLKVRKKELLQKMFV
  NCTC8325        LTHANLCNINLKIPCLTEQDKVSALLKSIDNKMNNQMNRIELLKERKKGLLQKMFI
  Newman          LTHANLCNINLKIPCLTEQDKVSALLKSIDNKMNNQMNRIELLKERKKGLLQKMFI
  USA300_FPR3757  LTHANLCNINLKIPCLTEQDKVSALLKSIDNKMNNQMNRIELLKERKKGLLQKMFI
                  *:: :* **: *:*.  **:*:. ::..**. :::* .::  ** *** ******: