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⊟Summary[edit | edit source]
- pan ID?: SAUPAN004575000
- symbol?: epiP
- synonym:
- description?: peptidase S8
- peptidase S8
- epidermin leader peptide processing serine protease EpiP
- intracellular serine protease
- lantibiotic epidermin leader peptide processing serine protease EpiP
- lantibiotic leader peptide processing serine protease
- lantibiotic epidermin serine protease
- serine protease precursor
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4807226..4808599
- synteny block?: BlockID0035600
- occurrence?: in 42% of 33 strains
bsaP: bacteriocin of Staphylococcus aureus leader peptide processing peptidase S8 [1]
A crystal structure is available: 3QFH
⊟Orthologs[edit | edit source]
04-02981:
—
08BA02176:
—
11819-97:
MS7_1819 (epiP)
6850:
—
71193:
—
ECT-R 2:
—
ED133:
SAOV_1803
ED98:
—
HO 5096 0412:
—
JH1:
—
JH9:
—
JKD6008:
—
JKD6159:
—
LGA251:
SARLGA251_17020
M013:
—
MRSA252:
—
MSHR1132:
—
MSSA476:
SAS1742
Mu3:
—
Mu50:
—
MW2:
MW1761 (bsaP)
RF122:
SAB1679c
ST398:
—
T0131:
SAT0131_01940
TCH60:
—
TW20:
SATW20_18160
USA300_TCH1516:
USA300HOU_1811 (epiP)
VC40:
SAVC_08330
⊟Genome Viewer[edit | edit source]
| COL | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKIIKRAIISLIILSLLISITMSNASASEELYYSVEYKNTATFNKLVKKKSLNVVYNIPE
NCTC8325 MKIIKRAIISLIILSLLISITMSNASASEELYYSVEYKNTATFNKLVKKKSLNVVYNIPE
Newman MKIIKRAIISLIILSLLISITMSNASASEELYYSVEYKNTATFNKLVKKKSLNVVYNIPE
USA300_FPR3757 MKIIKRAIISLIILSLLISITMSNASASEELYYSVEYKNTATFNKLVKKKSLNVVYNIPE
************************************************************
COL LHVAQIKMTKMHANALANYKNDIKYINATCSTCITSEKTIDRTSNESLFSRQWDMNKITN
NCTC8325 LHVAQIKMTKMHANALANYKNDIKYINATCSTCITSEKTIDRTSNESLFSRQWDMNKITN
Newman LHVAQIKMTKMHANALANYKNDIKYINATCSTCITSEKTIDRTSNESLFSRQWDMNKITN
USA300_FPR3757 LHVAQIKMTKMHANALANYKNDIKYINATCSTCITSEKTIDRTSNESLFSRQWDMNKITN
************************************************************
COL NGASYDDLPKHANTKIAIIDTGVMKNHDDLKNNFSTDSKNLVPLNGFRGTEPEETGDVHD
NCTC8325 NGASYDDLPKHANTKIAIIDTGVMKNHDDLKNNFSTDSKNLVPLNGFRGTEPEETGDVHD
Newman NGASYDDLPKHANTKIAIIDTGVMKNHDDLKNNFSTDSKNLVPLNGFRGTEPEETGDVHD
USA300_FPR3757 NGASYDDLPKHANTKIAIIDTGVMKNHDDLKNNFSTDSKNLVPLNGFRGTEPEETGDVHD
************************************************************
COL VNDRKGHGTMVSGQTSANGKLIGVAPNNKFTMYRVFGSKKTELLWVSKAIVQAANDGNQV
NCTC8325 VNDRKGHGTMVSGQTSANGKLIGVAPNNKFTMYRVFGSKKTELLWVSKAIVQAANDGNQV
Newman VNDRKGHGTMVSGQTSANGKLIGVAPNNKFTMYRVFGSKKTELLWVSKAIVQAANDGNQV
USA300_FPR3757 VNDRKGHGTMVSGQTSANGKLIGVAPNNKFTMYRVFGSKKTELLWVSKAIVQAANDGNQV
************************************************************
COL INISVGSYIILDKNDHQTFRKDEKVEYDALQKAINYAKKKKSIVVAAAGNDGIDVNDKQK
NCTC8325 INISVGSYIILDKNDHQTFRKDEKVEYDALQKAINYAKKKKSIVVAAAGNDGIDVNDKQK
Newman INISVGSYIILDKNDHQTFRKDEKVEYDALQKAINYAKKKKSIVVAAAGNDGIDVNDKQK
USA300_FPR3757 INISVGSYIILDKNDHQTFRKDEKVEYDALQKAINYAKKKKSIVVAAAGNDGIDVNDKQK
************************************************************
COL LKLQREYQGNGEVKDVPASMDNVVTVGSTDQKSNLSEFSNFGMNYTDIAAPGGSFAYLNQ
NCTC8325 LKLQREYQGNGEVKDVPASMDNVVTVGSTDQKSNLSEFSNFGMNYTDIAAPGGSFAYLNQ
Newman LKLQREYQGNGEVKDVPASMDNVVTVGSTDQKSNLSEFSNFGMNYTDIAAPGGSFAYLNQ
USA300_FPR3757 LKLQREYQGNGEVKDVPASMDNVVTVGSTDQKSNLSEFSNFGMNYTDIAAPGGSFAYLNQ
************************************************************
COL FGVDKWMNEGYMHKENILTTANNGRYIYQAGTSLATPKVSGALALIIDKYHLEKHPDKAI
NCTC8325 FGVDKWMNEGYMHKENILTTANNGRYIYQAGTSLATPKVSGALALIIDKYHLEKHPDKAI
Newman FGVDKWMNEGYMHKENILTTANNGRYIYQAGTSLATPKVSGALALIIDKYHLEKHPDKAI
USA300_FPR3757 FGVDKWMNEGYMHKENILTTANNGRYIYQAGTSLATPKVSGALALIIDKYHLEKHPDKAI
************************************************************
COL ELLYQHGTSKNNKPFSRYGHGELDVYKALNVANQKAS
NCTC8325 ELLYQHGTSKNNKPFSRYGHGELDVYKALNVANQKAS
Newman ELLYQHGTSKNNKPFSRYGHGELDVYKALNVANQKAS
USA300_FPR3757 ELLYQHGTSKNNKPFSRYGHGELDVYKALNVANQKAS
*************************************
- ↑ Karen M Daly, Mathew Upton, Stephanie K Sandiford, Lorraine A Draper, Philip A Wescombe, Ralph W Jack, Paula M O'Connor, Angela Rossney, Friedrich Götz, Colin Hill, Paul D Cotter, R Paul Ross, John R Tagg
Production of the Bsa lantibiotic by community-acquired Staphylococcus aureus strains.
J Bacteriol: 2010, 192(4);1131-42
[PubMed:20023032] [WorldCat.org] [DOI] (I p)Misty L Kuhn, Prachi Prachi, George Minasov, Ludmilla Shuvalova, Jiapeng Ruan, Ievgeniia Dubrovska, James Winsor, Monica Giraldi, Massimiliano Biagini, Sabrina Liberatori, Silvana Savino, Fabio Bagnoli, Wayne F Anderson, Guido Grandi
Structure and protective efficacy of the Staphylococcus aureus autocleaving protease EpiP.
FASEB J: 2014, 28(4);1780-93
[PubMed:24421400] [WorldCat.org] [DOI] (I p)