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PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

Summary[edit | edit source]

  • pan ID?: SAUPAN004576000
  • symbol?: epiD
  • synonym:
  • description?: enterotoxin

      descriptions from strain specific annotations:

    • enterotoxin
    • epidermin biosynthesis protein EpiD
    • flavoprotein EpiD
    • lantibiotic epidermin biosynthesis protein EpiD
    • lantibiotic modifying enzyme
    • epidermin decarboxylase
    • flavoprotein, epiD
    • lantibiotic decarboxylase
  • strand?: -
  • coordinates?: 4808609..4809127
  • synteny block?: BlockID0035600
  • occurrence?: in 42% of 33 strains

bsaD: bacteriocin of Staphylococcus aureus posttranslational C-terminus processing enzyme [1]

A crystal structure is available: 3QJG

Orthologs[edit | edit source]

    COL:
    SACOL1875 (epiD)
    N315:
    NCTC8325:
    Newman:
    NWMN_1713 (bsaD)
    USA300_FPR3757:
    04-02981:
    08BA02176:
    11819-97:
    MS7_1820 (epiD)
    6850:
    71193:
    ECT-R 2:
    ED133:
    SAOV_1804
    ED98:
    HO 5096 0412:
    JH1:
    JH9:
    JKD6008:
    JKD6159:
    LGA251:
    SARLGA251_17030
    M013:
    MRSA252:
    MSHR1132:
    MSSA476:
    SAS1743
    Mu3:
    Mu50:
    MW2:
    MW1762 (bsaD)
    RF122:
    SAB1680c
    ST398:
    T0131:
    SAT0131_01941 (pabB)
    TCH60:
    TW20:
    SATW20_18170
    USA300_TCH1516:
    USA300HOU_1812 (epiD)
    VC40:
    SAVC_08335

Genome Viewer[edit | edit source]

COL
NCTC8325
Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             -----MGENVLICLCGSVNSINISHYIIELKSKFDEVNVIASTNGRKFINGEILKQFCDN
    NCTC8325        -----MGENVLICLCGSVNSINISHYIIELKSKFDEVNVIASTNGRKFINGEILKQFCDN
    Newman          MEAYIMGENVLICLCGSVNSINISHYIIELKSKFDEVNVIASTNGRKFINGEILKQFCDN
    USA300_FPR3757  -----MGENVLICLCGSVNSINISHYIIELKSKFDEVNVIASTNGRKFINGEILKQFCDN
                         *******************************************************

    COL             YYDEFEDPFLNHVDIANKHDKIIILPATSNTINKIANGICDNLLLTICHTAFEKLSIFPN
    NCTC8325        YYDEFEDPFLNHVDIANKHDKIIILPATSNTINKIANGICDNLLLTICHTAFEKLSIFPN
    Newman          YYDEFEDPFLNHVDIANKHDKIIILPATSNTINKIANGICDNLLLTICHTAFEKLSIFPN
    USA300_FPR3757  YYDEFEDPFLNHVDIANKHDKIIILPATSNTINKIANGICDNLLLTICHTAFEKLSIFPN
                    ************************************************************

    COL             MNLRMWENPVTQNNIRLLKDYGVSIYPANISESYELASKTFKKNVVAPEPYKVLEFI
    NCTC8325        MNLRMWENPVTQNNIRLLKDYGVSIYPANISESYELASKTFKKNVVAPEPYKVLEFI
    Newman          MNLRMWENPVTQNNIRLLKDYGVSIYPANISESYELASKTFKKNVVAPEPYKVLEFI
    USA300_FPR3757  MNLRMWENPVTQNNIRLLKDYGVSIYPANISESYELASKTFKKNVVAPEPYKVLEFI
                    *********************************************************

  1. Karen M Daly, Mathew Upton, Stephanie K Sandiford, Lorraine A Draper, Philip A Wescombe, Ralph W Jack, Paula M O'Connor, Angela Rossney, Friedrich Götz, Colin Hill, Paul D Cotter, R Paul Ross, John R Tagg
    Production of the Bsa lantibiotic by community-acquired Staphylococcus aureus strains.
    J Bacteriol: 2010, 192(4);1131-42
    [PubMed:20023032] [WorldCat.org] [DOI] (I p)
    T Kupke, F Götz
    Post-translational modifications of lantibiotics.
    Antonie Van Leeuwenhoek: 1996, 69(2);139-50
    [PubMed:8775974] [WorldCat.org] [DOI] (P p)