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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005723000
- symbol?: —
- synonym:
- description?: MFS transporter
- MFS transporter
- drug transporter
- major facilitator superfamily drug transporter
- putative drug transporter
- drug transporter, putative
- Major facilitator family transporter
- major facilitator superfamily protein
- major facilitator superfamily protein (MFS)
- major facilitator superfamily transporter
- major facilitator transporter
- membrane transporter
- MFS family major facilitator transporter
- MFS superfamily transporter
- permease of the major facilitator superfamily
- putative transporter protein
- transporter protein
- transporter ybfD
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 5827908..5828951
- synteny block?: BlockID0044690
- occurrence?: in 100% of 34 strains
mepA2 : multidrug efflux MATE transporter 2 [1]
There is some confusion in the S. aureus literature regarding the MepRA transporters. Multiple papers and two crystal structures are available referring to two separate operons as MepRA. For clarity, we will annotate the operon between the ascorbate phosphotransferase operon and the glycerol-3-phosphate transporter (3ECO) as "Mep1" and the one between femX and sarV (4EM1) as Mep2.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2204
08BA02176:
C248_2303
11819-97:
MS7_2285
6850:
RSAU_002100
71193:
ST398NM01_2317
ECT-R 2:
ECTR2_2127
ED133:
SAOV_2304
ED98:
SAAV_2329
HO 5096 0412:
SAEMRSA15_21640
JH1:
SaurJH1_2333
JH9:
SaurJH9_2291
JKD6008:
SAA6008_02303
JKD6159:
SAA6159_02171
JSNZ:
JSNZ_002232
LGA251:
SARLGA251_20500
M013:
M013TW_2224
MRSA252:
SAR2350
MSHR1132:
SAMSHR1132_20910
MSSA476:
SAS2156
Mu3:
SAHV_2250
Mu50:
SAV2266
MW2:
MW2184
RF122:
SAB2138
ST398:
SAPIG2317
T0131:
SAT0131_02442
TCH60:
HMPREF0772_10934
TW20:
SATW20_23980
USA300_TCH1516:
USA300HOU_2247
VC40:
SAVC_10190
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MTNQGSLNKSPIFTKSFTINFLVNFIVYLCMYLLLVVIAGYSKQAFDASDSLAGLVVGLF
N315 MTNQGSLNKSPIFTKSFTINFFVNFIVYLCMYLLLVVIAGYSKQAFDASDSLAGLVVGLF
NCTC8325 MTNQGSLNKSPIFTKSFTINFLVNFIVYLCMYLLLVVIAGYSKQAFDASDSLAGLVVGLF
Newman MTNQGSLNKSPIFTKSFTINFLVNFIVYLCMYLLLVVIAGYSKQAFDASDSLAGLVVGLF
USA300_FPR3757 MTNQGSLNKSPIFTKSFTINFLVNFIVYLCMYLLLVVIAGYSKQAFDASDSLAGLVVGLF
*********************:**************************************
COL IVGSLIGRFATGKFVNQIGPKRLLFIGLIALIITQLLYFIDGSLAFLIFVRLINGIATAV
N315 IVGSLIGRFATGKFVNQIGPKRLLFIGLIALIITQLLYFIDGSLAFLIFVRLINGIATAV
NCTC8325 IVGSLIGRFATGKFVNQIGPKRLLFIGLIALIITQLLYFIDGSLAFLIFVRLINGIATAV
Newman IVGSLIGRFATGKFVNQIGPKRLLFIGLIALIITQLLYFIDGSLAFLIFVRLINGIATAV
USA300_FPR3757 IVGSLIGRFATGKFVNQIGPKRLLFIGLIALIITQLLYFIDGSLAFLIFVRLINGIATAV
************************************************************
COL VTTATGTIAAYVTPVNRKSEGISLFSLSLVLGTAIGPFLGMLLITKYAIDLLFIICVILG
N315 VTTATGTIAAYVTPVNRKSEGISLFSLSLVLGTAIGPFLGMLLITKYAIDLLFIICVILG
NCTC8325 VTTATGTIAAYVTPVNRKSEGISLFSLSLVLGTAIGPFLGMLLITKYAIDLLFIICVILG
Newman VTTATGTIAAYVTPVNRKSEGISLFSLSLVLGTAIGPFLGMLLITKYAIDLLFIICVILG
USA300_FPR3757 VTTATGTIAAYVTPVNRKSEGISLFSLSLVLGTAIGPFLGMLLITKYAIDLLFIICVILG
************************************************************
COL ILGLIISLFIKVDFEVTNNKTETNVIDKPRFSIHQFIAKEAIPVAVIMLLIGVTYASILT
N315 ILGLIISLFIKVDFEVTNNKTETDVINKPRFSIHQFIAKEAIPVAVIMLLIGVTYASILT
NCTC8325 ILGLIISLFIKVDFEVTNNKTETNVIDKPRFSIHQFIAKEAIPVAVIMLLIGVTYASILT
Newman ILGLIISLFIKVDFEVTNNKTETNVIDKPRFSIHQFIAKEAIPVAVIMLLIGVTYASILT
USA300_FPR3757 ILGLIISLFIKVDFEVTNNKTETNVIDKPRFSIHQFIAKEAIPVAVIMLLIGVTYASILT
***********************:**:*********************************
COL YLQAFALERHLVTAASYFFICYAIASLITRPIAGRLMDDKNENIIVYPAFIMLFLSFVCL
N315 YLQAFALERHLVTAASYFFICYAIASLITRPIAGRLMDDKNENIIVYPAFIMLFLSFVCL
NCTC8325 YLQAFALERHLVTAASYFFICYAIASLITRPIAGRLMDDKNENIIVYPAFIMLFLSFVCL
Newman YLQAFALERHLVTAASYFFICYAIASLITRPIAGRLMDDKNENIIVYPAFIMLFLSFVCL
USA300_FPR3757 YLQAFALERHLVTAASYFFICYAIASLITRPIAGRLMDDKNENIIVYPAFIMLFLSFVCL
************************************************************
COL ISSYQSWLILLAGACLGLGYGNLSSAMQSIAIKVSPPIKYGIATSTFYVGLDAGVGFGPS
N315 ISSYQSWLILLAGACLGLGYGNLSSAMQSIAIKVSPPIKYGIATSTFYVGLDAGVGFGPS
NCTC8325 ISSYQSWLILLAGACLGLGYGNLSSAMQSIAIKVSPPIKYGIATSTFYVGLDAGVGFGPS
Newman ISSYQSWLILLAGACLGLGYGNLSSAMQSIAIKVSPPIKYGIATSTFYVGLDAGVGFGPS
USA300_FPR3757 ISSYQSWLILLAGACLGLGYGNLSSAMQSIAIKVSPPIKYGIATSTFYVGLDAGVGFGPS
************************************************************
COL FLGLFTHMFSYSEIFGFMAALAIITMLVYFLIHGRHVTRNAMN
N315 FLGLFTHMFSYSEIFGFMAALAIITMLVYFLIHGRHVTRNAMN
NCTC8325 FLGLFTHMFSYSEIFGFMAALAIITMLVYFLIHGRHVTRNAMN
Newman FLGLFTHMFSYSEIFGFMAALAIITMLVYFLIHGRHVTRNAMN
USA300_FPR3757 FLGLFTHMFSYSEIFGFMAALAIITMLVYFLIHGRHVTRNAMN
*******************************************
- ↑ Ivan Birukou, Nam K Tonthat, Susan M Seo, Bryan D Schindler, Glenn W Kaatz, Richard G Brennan
The molecular mechanisms of allosteric mutations impairing MepR repressor function in multidrug-resistant strains of Staphylococcus aureus.
mBio: 2013, 4(5);e00528-13
[PubMed:23982071] [WorldCat.org] [DOI] (I e)Ivan Birukou, Susan M Seo, Bryan D Schindler, Glenn W Kaatz, Richard G Brennan
Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR.
Nucleic Acids Res: 2014, 42(4);2774-88
[PubMed:24293644] [WorldCat.org] [DOI] (I p)