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Summary[edit | edit source]

  • pan ID?: SAUPAN005723000
  • symbol?:
  • synonym:
  • description?: MFS transporter

      descriptions from strain specific annotations:

    • MFS transporter
    • drug transporter
    • major facilitator superfamily drug transporter
    • putative drug transporter
    • drug transporter, putative
    • Major facilitator family transporter
    • major facilitator superfamily protein
    • major facilitator superfamily protein (MFS)
    • major facilitator superfamily transporter
    • major facilitator transporter
    • membrane transporter
    • MFS family major facilitator transporter
    • MFS superfamily transporter
    • permease of the major facilitator superfamily
    • putative transporter protein
    • transporter protein
    • transporter ybfD
  • strand?: +
  • coordinates?: 5827908..5828951
  • synteny block?: BlockID0044690
  • occurrence?: in 100% of 34 strains

mepA2 : multidrug efflux MATE transporter 2 [1]

There is some confusion in the S. aureus literature regarding the MepRA transporters. Multiple papers and two crystal structures are available referring to two separate operons as MepRA. For clarity, we will annotate the operon between the ascorbate phosphotransferase operon and the glycerol-3-phosphate transporter (3ECO) as "Mep1" and the one between femX and sarV (4EM1) as Mep2.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    SA2981_2204
    08BA02176:
    C248_2303
    11819-97:
    MS7_2285
    6850:
    RSAU_002100
    71193:
    ST398NM01_2317
    ECT-R 2:
    ECTR2_2127
    ED133:
    SAOV_2304
    ED98:
    SAAV_2329
    HO 5096 0412:
    SAEMRSA15_21640
    JH1:
    SaurJH1_2333
    JH9:
    SaurJH9_2291
    JKD6008:
    SAA6008_02303
    JKD6159:
    SAA6159_02171
    JSNZ:
    JSNZ_002232
    LGA251:
    SARLGA251_20500
    M013:
    M013TW_2224
    MRSA252:
    SAR2350
    MSHR1132:
    SAMSHR1132_20910
    MSSA476:
    SAS2156
    Mu3:
    SAHV_2250
    Mu50:
    SAV2266
    MW2:
    MW2184
    RF122:
    SAB2138
    ST398:
    SAPIG2317
    T0131:
    SAT0131_02442
    TCH60:
    HMPREF0772_10934
    TW20:
    SATW20_23980
    USA300_TCH1516:
    USA300HOU_2247
    VC40:
    SAVC_10190

Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MTNQGSLNKSPIFTKSFTINFLVNFIVYLCMYLLLVVIAGYSKQAFDASDSLAGLVVGLF
    N315            MTNQGSLNKSPIFTKSFTINFFVNFIVYLCMYLLLVVIAGYSKQAFDASDSLAGLVVGLF
    NCTC8325        MTNQGSLNKSPIFTKSFTINFLVNFIVYLCMYLLLVVIAGYSKQAFDASDSLAGLVVGLF
    Newman          MTNQGSLNKSPIFTKSFTINFLVNFIVYLCMYLLLVVIAGYSKQAFDASDSLAGLVVGLF
    USA300_FPR3757  MTNQGSLNKSPIFTKSFTINFLVNFIVYLCMYLLLVVIAGYSKQAFDASDSLAGLVVGLF
                    *********************:**************************************

    COL             IVGSLIGRFATGKFVNQIGPKRLLFIGLIALIITQLLYFIDGSLAFLIFVRLINGIATAV
    N315            IVGSLIGRFATGKFVNQIGPKRLLFIGLIALIITQLLYFIDGSLAFLIFVRLINGIATAV
    NCTC8325        IVGSLIGRFATGKFVNQIGPKRLLFIGLIALIITQLLYFIDGSLAFLIFVRLINGIATAV
    Newman          IVGSLIGRFATGKFVNQIGPKRLLFIGLIALIITQLLYFIDGSLAFLIFVRLINGIATAV
    USA300_FPR3757  IVGSLIGRFATGKFVNQIGPKRLLFIGLIALIITQLLYFIDGSLAFLIFVRLINGIATAV
                    ************************************************************

    COL             VTTATGTIAAYVTPVNRKSEGISLFSLSLVLGTAIGPFLGMLLITKYAIDLLFIICVILG
    N315            VTTATGTIAAYVTPVNRKSEGISLFSLSLVLGTAIGPFLGMLLITKYAIDLLFIICVILG
    NCTC8325        VTTATGTIAAYVTPVNRKSEGISLFSLSLVLGTAIGPFLGMLLITKYAIDLLFIICVILG
    Newman          VTTATGTIAAYVTPVNRKSEGISLFSLSLVLGTAIGPFLGMLLITKYAIDLLFIICVILG
    USA300_FPR3757  VTTATGTIAAYVTPVNRKSEGISLFSLSLVLGTAIGPFLGMLLITKYAIDLLFIICVILG
                    ************************************************************

    COL             ILGLIISLFIKVDFEVTNNKTETNVIDKPRFSIHQFIAKEAIPVAVIMLLIGVTYASILT
    N315            ILGLIISLFIKVDFEVTNNKTETDVINKPRFSIHQFIAKEAIPVAVIMLLIGVTYASILT
    NCTC8325        ILGLIISLFIKVDFEVTNNKTETNVIDKPRFSIHQFIAKEAIPVAVIMLLIGVTYASILT
    Newman          ILGLIISLFIKVDFEVTNNKTETNVIDKPRFSIHQFIAKEAIPVAVIMLLIGVTYASILT
    USA300_FPR3757  ILGLIISLFIKVDFEVTNNKTETNVIDKPRFSIHQFIAKEAIPVAVIMLLIGVTYASILT
                    ***********************:**:*********************************

    COL             YLQAFALERHLVTAASYFFICYAIASLITRPIAGRLMDDKNENIIVYPAFIMLFLSFVCL
    N315            YLQAFALERHLVTAASYFFICYAIASLITRPIAGRLMDDKNENIIVYPAFIMLFLSFVCL
    NCTC8325        YLQAFALERHLVTAASYFFICYAIASLITRPIAGRLMDDKNENIIVYPAFIMLFLSFVCL
    Newman          YLQAFALERHLVTAASYFFICYAIASLITRPIAGRLMDDKNENIIVYPAFIMLFLSFVCL
    USA300_FPR3757  YLQAFALERHLVTAASYFFICYAIASLITRPIAGRLMDDKNENIIVYPAFIMLFLSFVCL
                    ************************************************************

    COL             ISSYQSWLILLAGACLGLGYGNLSSAMQSIAIKVSPPIKYGIATSTFYVGLDAGVGFGPS
    N315            ISSYQSWLILLAGACLGLGYGNLSSAMQSIAIKVSPPIKYGIATSTFYVGLDAGVGFGPS
    NCTC8325        ISSYQSWLILLAGACLGLGYGNLSSAMQSIAIKVSPPIKYGIATSTFYVGLDAGVGFGPS
    Newman          ISSYQSWLILLAGACLGLGYGNLSSAMQSIAIKVSPPIKYGIATSTFYVGLDAGVGFGPS
    USA300_FPR3757  ISSYQSWLILLAGACLGLGYGNLSSAMQSIAIKVSPPIKYGIATSTFYVGLDAGVGFGPS
                    ************************************************************

    COL             FLGLFTHMFSYSEIFGFMAALAIITMLVYFLIHGRHVTRNAMN
    N315            FLGLFTHMFSYSEIFGFMAALAIITMLVYFLIHGRHVTRNAMN
    NCTC8325        FLGLFTHMFSYSEIFGFMAALAIITMLVYFLIHGRHVTRNAMN
    Newman          FLGLFTHMFSYSEIFGFMAALAIITMLVYFLIHGRHVTRNAMN
    USA300_FPR3757  FLGLFTHMFSYSEIFGFMAALAIITMLVYFLIHGRHVTRNAMN
                    *******************************************

  1. Ivan Birukou, Nam K Tonthat, Susan M Seo, Bryan D Schindler, Glenn W Kaatz, Richard G Brennan
    The molecular mechanisms of allosteric mutations impairing MepR repressor function in multidrug-resistant strains of Staphylococcus aureus.
    mBio: 2013, 4(5);e00528-13
    [PubMed:23982071] [WorldCat.org] [DOI] (I e)
    Ivan Birukou, Susan M Seo, Bryan D Schindler, Glenn W Kaatz, Richard G Brennan
    Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR.
    Nucleic Acids Res: 2014, 42(4);2774-88
    [PubMed:24293644] [WorldCat.org] [DOI] (I p)