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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005753000
- symbol?: ureA
- synonym:
- description?: urease subunit gamma
- urease subunit gamma
- urease, gamma subunit
- Urease gamma subunit
- urease gamma subunit UreA
- urease subunit gamma (Urea amidohydrolase subunit gamma)
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 5848458..5848805
- synteny block?: BlockID0044990
- occurrence?: in 100% of 34 strains
ureA : urease subunit gamma [1]
Urease (alt: urea amidohydrolase) processes urea into more bioavailable ammonia and bicarbonate. The overall structure consists of a trimer of alpha-beta-gamma subunit heterotrimers. Apo-urease must be "activated" to its functional form by urease accessory proteins including carbamoylation of lysine-221 of the alpha subunit and formation of a diatomic nickel metallocenter.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2226 (ureA)
08BA02176:
C248_2327 (ureA)
11819-97:
MS7_2306 (ureA)
6850:
RSAU_002121 (ureA)
71193:
ST398NM01_2338
ECT-R 2:
ECTR2_2148 (ureA)
ED133:
SAOV_2327
ED98:
SAAV_2350 (ureA)
HO 5096 0412:
SAEMRSA15_21850 (ureA)
JH1:
SaurJH1_2355 (ureA)
JH9:
SaurJH9_2312 (ureA)
JKD6008:
SAA6008_02324 (ureA)
JKD6159:
SAA6159_02192 (ureA)
JSNZ:
JSNZ_002254
LGA251:
SARLGA251_20710 (ureA)
M013:
M013TW_2245
MRSA252:
SAR2372 (ureA)
MSHR1132:
SAMSHR1132_21130
MSSA476:
SAS2178 (ureA)
Mu3:
SAHV_2272 (ureA)
Mu50:
SAV2288 (ureA)
MW2:
MW2206 (ureA)
RF122:
SAB2160 (ureA)
ST398:
SAPIG2338 (ureA)
T0131:
SAT0131_02465
TCH60:
HMPREF0772_10910 (ureA)
TW20:
SATW20_24190 (ureA)
USA300_TCH1516:
USA300HOU_2269 (ureA)
VC40:
SAVC_10300 (ureA)
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MHFTQREQDKLMIVVAAEVARRRKARGLKLNHPEALALISDELLEGARDGKTVAELMSYG
N315 MHFTQREQDKLMIVVAAEVARRRKARGLKLNHPEALALISDELLEGARDGKTVAELMSYG
NCTC8325 MHFTQREQDKLMIVVAAEVARRRKARGLKLNHPEALALISDELLEGARDGKTVAELMSYG
Newman MHFTQREQDKLMIVVAAEVARRRKARGLKLNHPEALALISDELLEGARDGKTVAELMSYG
USA300_FPR3757 MHFTQREQDKLMIVVAAEVARRRKARGLKLNHPEALALISDELLEGARDGKTVAELMSYG
************************************************************
COL RQILNKEDVMDGVEHMITDIEIEATFPDGTKLITVHHPIV
N315 RQILNKEDVMDGVEHMITDIEIEATFPDGTKLITVHHPIV
NCTC8325 RQILNKEDVMDGVEHMITDIEIEATFPDGTKLITVHHPIV
Newman RQILNKEDVMDGVEHMITDIEIEATFPDGTKLITVHHPIV
USA300_FPR3757 RQILNKEDVMDGVEHMITDIEIEATFPDGTKLITVHHPIV
****************************************
- ↑ Chunyi Zhou, Fatema Bhinderwala, McKenzie K Lehman, Vinai C Thomas, Sujata S Chaudhari, Kelsey J Yamada, Kirk W Foster, Robert Powers, Tammy Kielian, Paul D Fey
Urease is an essential component of the acid response network of Staphylococcus aureus and is required for a persistent murine kidney infection.
PLoS Pathog: 2019, 15(1);e1007538
[PubMed:30608981] [WorldCat.org] [DOI] (I e)S C Rizzo, G Grignani, G Gamba, G Bedarida, F D'Agostino
Intravenous gammaglobulin therapy for chronic idiopathic thrombocytopenic purpura in adults.
Haematologica: 1985, 70(4);337-40
[PubMed:3935533] [WorldCat.org] (P p)