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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005754000
- symbol?: ureB
- synonym:
- description?: urease subunit beta
- urease subunit beta
- urease, beta subunit, putative
- urease, beta subunit
- Urease beta subunit
- urease subunit beta (Urea amidohydrolase subunit beta)
- urease subunit beta UreB
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 5848798..5849280
- synteny block?: BlockID0045000
- occurrence?: in 100% of 34 strains
ureB : urease subunit beta [1]
Urease (alt: urea amidohydrolase) processes urea into more bioavailable ammonia and bicarbonate. The overall structure consists of a trimer of alpha-beta-gamma subunit heterotrimers. Apo-urease must be "activated" to its functional form by urease accessory proteins including carbamoylation of lysine-221 of the alpha subunit and formation of a diatomic nickel metallocenter.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2227 (ureB)
08BA02176:
C248_2328 (ureB)
11819-97:
MS7_2307 (ureB)
6850:
RSAU_002122 (ureB)
71193:
ST398NM01_2339
ECT-R 2:
ECTR2_2149 (ureB)
ED133:
SAOV_2328
ED98:
SAAV_2351 (ureB)
HO 5096 0412:
SAEMRSA15_21860 (ureB)
JH1:
SaurJH1_2356 (ureB)
JH9:
SaurJH9_2313 (ureB)
JKD6008:
SAA6008_02325 (ureB)
JKD6159:
SAA6159_02193 (ureB)
JSNZ:
JSNZ_002255
LGA251:
SARLGA251_20720 (ureB)
M013:
M013TW_2246
MRSA252:
SAR2373 (ureB)
MSHR1132:
SAMSHR1132_21140
MSSA476:
SAS2179 (ureB)
Mu3:
SAHV_2273 (ureB)
Mu50:
SAV2289 (ureB)
MW2:
MW2207 (ureB)
RF122:
SAB2161 (ureB)
ST398:
SAPIG2339 (ureB)
T0131:
SAT0131_02466 (panD)
TCH60:
HMPREF0772_10909 (ureB)
TW20:
SATW20_24200 (ureB)
USA300_TCH1516:
USA300HOU_2270 (ureB)
VC40:
SAVC_10305 (ureB)
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MIPGEIITKSTEVEINNHHPETVIEVENTGDRPIQVGSHFHFYEANAALDFEREMAYGKH
N315 MIPGEIITKSTEVEINNHHPETVIEVENTGDRPIQVGSHFHFYEANAALDFEREMAYGKH
NCTC8325 MIPGEIITKSTEVEINNHHPETVIEVENTGDRPIQVGSHFHFYEANAALDFEREMAYGKH
Newman MIPGEIITKSTEVEINNHHPETVIEVENTGDRPIQVGSHFHFYEANAALDFEREMAYGKH
USA300_FPR3757 MIPGEIITKSTEVEINNHHPETVIEVENTGDRPIQVGSHFHFYEANAALDFEREMAYGKH
************************************************************
COL LDIPAGAAVRFEPGDKKEVQLVEYAGKRKIFGFRGMVNGPIDESRVYRPTDENDEYAGVF
N315 LDIPAGAAVRFEPGDKKEVQLVEYAGKRKIFGFRGMVNGPIDESRVYRPTDENDAYAGVF
NCTC8325 LDIPAGAAVRFEPGDKKEVQLVEYAGKRKIFGFRGMVNGPIDESRVYRPTDENDEYAGVF
Newman LDIPAGAAVRFEPGDKKEVQLVEYAGKRKIFGFRGMVNGPIDESRVYRPTDENDEYAGVF
USA300_FPR3757 LDIPAGAAVRFEPGDKKEVQLVEYAGKRKIFGFRGMVNGPIDESRVYRPTDENDEYAGVF
****************************************************** *****
COL GDNGAENVNKKGGKRS
N315 GDNGAENVNKKGGKRS
NCTC8325 GDNGAENVNKKGGKRS
Newman GDNGAENVNKKGRKRS
USA300_FPR3757 GDNGAENVNKKGGKRS
************ ***
- ↑ Chunyi Zhou, Fatema Bhinderwala, McKenzie K Lehman, Vinai C Thomas, Sujata S Chaudhari, Kelsey J Yamada, Kirk W Foster, Robert Powers, Tammy Kielian, Paul D Fey
Urease is an essential component of the acid response network of Staphylococcus aureus and is required for a persistent murine kidney infection.
PLoS Pathog: 2019, 15(1);e1007538
[PubMed:30608981] [WorldCat.org] [DOI] (I e)