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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005788000
- symbol?: —
- synonym:
- description?: transcriptional regulator
- transcriptional regulator
- cell envelope-related transcriptional attenuator
- LCP family protein
- LytR family cell envelope-related transcriptional attenuator
- putative transcriptional regulator
- membrane-bound protein lytR
- transcriptional regulator, putative
- cell envelope-associated transcriptional attenuator
- Cell envelope-associated transcriptional attenuator LytR-CpsA-Psr, subfamily F2
- cell envelope transcriptional attenuator
- LytR family transcriptional regulator
- transcriptional regulator lytR
- transcription antiterminator LytR
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 5875795..5876649
- synteny block?: BlockID0045330
- occurrence?: in 100% of 34 strains
lcpC : capsular polysaccharide:peptidoglycan ligase C [1]
LCP ligases facilitate the attachment of capsular polysaccharides and wall teichoic acids to extracellular peptidoglycan. Staphylococcus aureus produces three LCP ligases and loss of even one paralogue can reduce pathogenicity by altering adhesion and resistance to cell wall-active antimicrobial agents. Although the functional redundancy and substrate overlap is significant, LcpC is the primary LCP ligase responsible for attachment of capsule polysaccharides to peptidoglycan.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2249
08BA02176:
C248_2352
11819-97:
MS7_2327
6850:
RSAU_002147
71193:
ST398NM01_2361
ECT-R 2:
ECTR2_2169
ED133:
SAOV_2350c
ED98:
SAAV_2372
HO 5096 0412:
SAEMRSA15_22080
JH1:
SaurJH1_2377
JH9:
SaurJH9_2334
JKD6008:
SAA6008_02345
JKD6159:
SAA6159_02214
JSNZ:
JSNZ_002277
LGA251:
SARLGA251_20930
M013:
M013TW_2267
MRSA252:
SAR2394
MSHR1132:
SAMSHR1132_21350
MSSA476:
SAS2202
Mu3:
SAHV_2294
Mu50:
SAV2310
MW2:
MW2230
RF122:
SAB2187c
ST398:
SAPIG2361
T0131:
SAT0131_02490 (sdhA)
TCH60:
HMPREF0772_10885 (lytR2)
TW20:
SATW20_24410
USA300_TCH1516:
USA300HOU_2292
VC40:
SAVC_10410
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MGLKRSSKSKMSLPKKIFLWVFGILVILAIVAVVYVAAKIFITGNKIHNPLDRNHSELRD
N315 --MKRSSKSKMSLPKKIFLWVFGILVILAIVAVVYVAAKIFITGNKIHNPLDRNHSELRD
NCTC8325 ----------MSLPKKIFLWVFGILVILAIVAVVYVAAKIFITGNKIHNPLDRNHSELRD
Newman --MKRSSKSKMSLPKKIFLWVFGILVILAIVAVVYVAAKIFITGNKIHNPLDRNHSELRD
USA300_FPR3757 ----------MSLPKKIFLWVFGILVILAIVAVVYVAAKIFITGNKIHNPLDRNHSELRD
**************************************************
COL KKVSLNDGDPFTIALFGVDSDADRKKKGGGERSDSIMILSINPKTKKTEIVSIPRDTRAE
N315 KKVSLNDGDPFTIALFGVDSDADRKKKGGGERSDSIMILSINPKTKKTEIVSIPRDTRAE
NCTC8325 KKVSLNDGDPFTIALFGVDSDADRKKKGGGERSDSIMILSINPKTKKTEIVSIPRDTRAE
Newman KKVSLNDGDPFTIALFGVDSDADRKKKGGGERSDSIMILSINPKTKKTEIVSIPRDTRAE
USA300_FPR3757 KKVSLNDGDPFTIALFGVDSDADRKKKGGGERSDSIMILSINPKTKKTEIVSIPRDTRAE
************************************************************
COL IVGRGTTEKIAHAYAYGGPNMAVKSLEKLMNVPIDHYATIDMDGLHNMIDSIGGVDVVSN
N315 IVGRGTTEKIAHAYAYGGPNMAVKSLEKLMNVPIDHYATIDMDGLHNMIDSIGGVDVVSN
NCTC8325 IVGRGTTEKIAHAYAYGGPNMAVKSLEKLMNVPIDHYATIDMDGLHNMIDSIGGVDVVSN
Newman IVGRGTTEKIAHAYAYGGPNMAVKSLEKLMNVPIDHYATIDMDGLHNMIDSIGGVDVVSN
USA300_FPR3757 IVGRGTTEKIAHAYAYGGPNMAVKSLEKLMNVPIDHYATIDMDGLHNMIDSIGGVDVVSN
************************************************************
COL DTFTVDGVRFTKGQQTHVNGDQALKFIRSRKEEGAGGDFGRQQRQQIVLEAMANKIASPS
N315 DTFTVDGVRFTKGQQTHVNGDQALKFIRSRKEEGAGGDFGRQQRQQIVLEAMANKIASPS
NCTC8325 DTFTVDGVRFTKGQQTHVNGDQALKFIRSRKEEGAGGDFGRQQRQQIVLEAMANKIASPS
Newman DTFTVDGVRFTKGQQTHVNGDQALKFIRSRKEEGAGGDFGRQQRQQIVLEAMANKIASPS
USA300_FPR3757 DTFTVDGVRFTKGQQTHVNGDQALKFIRSRKEEGAGGDFGRQQRQQIVLEAMANKIASPS
************************************************************
COL SITHFNSLMNEIQNNVKTDLTLGDLNTIRSNYKDANDTINKHQLSGQGGIQSDGLYYFIP
N315 SITHFNSLMNEIQNNVKTDLTLGDLNTIRSNYKDANDTINKHQLSGQGGIQSDGLYYFIP
NCTC8325 SITHFNSLMNEIQNNVKTDLTLGDLNTIRSNYKDANDTINKHQLSGQGGIQSDGLYYFIP
Newman SITHFNSLMNEIQNNVKTDLTLGDLNTIRSNYKDANDTINKHQLSGQGGIQSDGLYYFIP
USA300_FPR3757 SITHFNSLMNEIQNNVKTDLTLGDLNTIRSNYKDANDTINKHQLSGQGGIQSDGLYYFIP
************************************************************
COL SEQSKAESTKLLKDNLE
N315 SEQSKAESTKLLKDNLE
NCTC8325 SEQSKAESTKLLKDNLE
Newman SEQSKAESTKLLKDNLE
USA300_FPR3757 SEQSKAESTKLLKDNLE
*****************
- ↑ Yvonne Gar-Yun Chan, Hwan Keun Kim, Olaf Schneewind, Dominique Missiakas
The capsular polysaccharide of Staphylococcus aureus is attached to peptidoglycan by the LytR-CpsA-Psr (LCP) family of enzymes.
J Biol Chem: 2014, 289(22);15680-90
[PubMed:24753256] [WorldCat.org] [DOI] (I p)Kaitlin Schaefer, Leigh M Matano, Yuan Qiao, Daniel Kahne, Suzanne Walker
In vitro reconstitution demonstrates the cell wall ligase activity of LCP proteins.
Nat Chem Biol: 2017, 13(4);396-401
[PubMed:28166208] [WorldCat.org] [DOI] (I p)