⊟Summary[edit | edit source]

pan ID^?: SAUPAN005870000
symbol^?: hssR
synonym:
description^?: DNA-binding response regulator
- DNA-binding response regulator
- DNA-binding heme response regulator HssR
- response regulator protein
- two-component response regulator, putative
- heme response regulator HssR
- two component response regulator
- hemin DNA-binding response regulator
- response regulator receiver
- Two-component response regulator colocalized with HrtAB transporter
- two component transcriptional regulator
- winged helix family two component transcriptional regulator
strand^?: +
coordinates^?: 5942373..5943074
synteny block^?: BlockID0046150
occurrence^?: in 100% of 34 strains

hssR : heme sensor system response regulator ^[1]

• The HssR Regulon consists of Two Genes

⊟Orthologs[edit | edit source]

COL:

N315:

NCTC8325:

Newman:

USA300_FPR3757:

JSNZ:

JSNZ_002330 (hssR)

04-02981:

SA2981_2300

08BA02176:

C248_2406

11819-97:

MS7_2379 (hssR)

6850:

RSAU_002196

71193:

ST398NM01_2414

ECT-R 2:

ECTR2_2221

ED133:

SAOV_2405

ED98:

SAAV_2426

HO 5096 0412:

SAEMRSA15_22590

JH1:

SaurJH1_2431

JH9:

SaurJH9_2385

JKD6008:

SAA6008_02399 (hssR)

JKD6159:

SAA6159_02265 (hssR)

LGA251:

SARLGA251_21440 (hssR)

M013:

M013TW_2319

MRSA252:

SAR2447

MSHR1132:

SAMSHR1132_21860

MSSA476:

SAS2252

Mu3:

SAHV_2345

Mu50:

SAV2361

MW2:

MW2282

RF122:

SAB2240

ST398:

SAPIG2414

T0131:

SAT0131_02549 (spc)

TCH60:

HMPREF0772_10831 (regX)

TW20:

SATW20_24930 (hssR)

USA300_TCH1516:

USA300HOU_2344 (hssR)

VC40:

SAVC_10675

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

alignment of orthologues:
CLUSTAL format alignment by MAFFT L-INS-i (v7.505)

COL             MVQCLVVDDDPRILNYIASHLQIEHIDAYTQPSGEAALKLLEKQRVDIAVVDIMMDGMDG
N315            MVQCLVVDDDPRILNYIASHLQTEHIDAYTQPSGEAALKLLEKQRVDIAVVDIMMDGMDG
NCTC8325        MVQCLVVDDDPRILNYIASHLQTEHIDAYTQPSGEAALKLLEKQRVDIAVVDIMMDGMDG
Newman          MVQCLVVDDDPRILNYIASHLQIEHIDAYTQPSGEAALKLLEKQRVDIAVVDIMMDGMDG
USA300_FPR3757  MVQCLVVDDDPRILNYIASHLQTEHIDAYTQPSGEAALKLLEKQRVDIAVVDIMMDGMDG
JSNZ            MVQCLVVDDDPRILNYIASHLQTEHIDAYTQPSGEAALKLLEKQRVDIAVVDIMMDGMDG
                ********************** *************************************

COL             FQLCNTLKNDYDIPVIMLTARDALSDKERAFISGTDDYVTKPFEVKELIFRIRAVLRRYN
N315            FQLCNTLKNDYDIPVIMLTARDALSDKERAFISGTDDYVTKPFEVKELIFRIRAVLRRYN
NCTC8325        FQLCNTLKNDYDIPVIMLTARDALSDKERAFISGTDDYVTKPFEVKELIFRIRAVLRRYN
Newman          FQLCNTLKNDYDIPVIMLTARDALSDKERAFISGTDDYVTKPFEVKELIFRIRAVLRRYN
USA300_FPR3757  FQLCNTLKNDYDIPVIMLTARDALSDKERAFISGTDDYVTKPFEVKELIFRIRAVLRRYN
JSNZ            FQLCNTLKNDYDIPVIMLTARDALSDKERAFISGTDDYVTKPFEVKELIFRIRAVLRRYN
                ************************************************************

COL             INSNSEMTIGNLTLNQSYLELQVSNKTMTLPNKEFQLLFMLAARPKQIFTREQIIEKIWG
N315            INSNSEMTIGNLTLNQSYLELQVSNKTMTLPNKEFQLLFMLAARPKQIFTREQIIEKIWG
NCTC8325        INSNSEMTIGNLTLNQSYLELQVSNKTMTLPNKEFQLLFMLAARPKQIFTREQIIEKIWG
Newman          INSNSEMTIGNLTLNQSYLELQVSNKTMTLPNKEFQLLFMLAARPKQIFTREQIIEKIWG
USA300_FPR3757  INSNSEMTIGNLTLNQSYLELQVSNKTMTLPNKEFQLLFMLAARPKQIFTREQIIEKIWG
JSNZ            INSNSEMTIGNLTLNQSYLELQVSNKTMTLPNKEFQLLFMLAARPKQIFTREQIIEKIWG
                ************************************************************

COL             YDYEGDERTVDVHIKRLRQRLKKLNATLTIETVRGQGYKVENHV
N315            YDYEGDERTVDVHIKRLRQRLKKLNATLTIETVRGQGYKVENHV
NCTC8325        YDYEGDERTVDVHIKRLRQRLKKLNATLTIETVRGQGYKVENHV
Newman          YDYEGDERTVDVHIKRLRQRLKKLNATLTIETVRGQGYKVENHV
USA300_FPR3757  YDYEGDERTVDVHIKRLRQRLKKLNATLTIETVRGQGYKVENHV
JSNZ            YDYEGDERTVDVHIKRLRQRLKKLNATLTIETVRGQGYKVENHV
                ********************************************

↑ Devin L Stauff, Victor J Torres, Eric P Skaar
Signaling and DNA-binding activities of the Staphylococcus aureus HssR-HssS two-component system required for heme sensing.
J Biol Chem: 2007, 282(36);26111-21
[PubMed:17635909] [WorldCat.org] [DOI] (P p)Lisa Bleul, Patrice Francois, Christiane Wolz
Two-Component Systems of S. aureus: Signaling and Sensing Mechanisms.
Genes (Basel): 2021, 13(1);
[PubMed:35052374] [WorldCat.org] [DOI] (I e)Vincent Saillant, Léo Morey, Damien Lipuma, Pierre Boëton, Marina Siponen, Pascal Arnoux, Delphine Lechardeur
HssS activation by membrane heme defines a paradigm for two-component system signaling in Staphylococcus aureus.
mBio: 2024, 15(6);e0023024
[PubMed:38682935] [WorldCat.org] [DOI] (I p)

[1] Devin L Stauff, Victor J Torres, Eric P Skaar
Signaling and DNA-binding activities of the Staphylococcus aureus HssR-HssS two-component system required for heme sensing.
J Biol Chem: 2007, 282(36);26111-21
[PubMed:17635909] [WorldCat.org] [DOI] (P p)Lisa Bleul, Patrice Francois, Christiane Wolz
Two-Component Systems of S. aureus: Signaling and Sensing Mechanisms.
Genes (Basel): 2021, 13(1);
[PubMed:35052374] [WorldCat.org] [DOI] (I e)Vincent Saillant, Léo Morey, Damien Lipuma, Pierre Boëton, Marina Siponen, Pascal Arnoux, Delphine Lechardeur
HssS activation by membrane heme defines a paradigm for two-component system signaling in Staphylococcus aureus.
mBio: 2024, 15(6);e0023024
[PubMed:38682935] [WorldCat.org] [DOI] (I p)

[1]

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Contents

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757
JSNZ

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⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]