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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005890000
- symbol?: iruO
- synonym:
- description?: ferredoxin--NADP(+) reductase
- ferredoxin--NADP(+) reductase
- pyridine nucleotide-disulfide oxidoreductase
- NAD(P)/FAD-dependent oxidoreductase
- pyridine nucleotide-disulfide oxidoreductase family protein
- thioredoxin reductase
- thioredoxin reductase, putative
- FAD-dependent pyridine nucleotide-disulfide oxidoreductase
- ferredoxin--NADP reductase
- pyridine nucleotide-disulphide oxidoreductase family protein
- Pyridine oxidoreductase
- thioredoxin-disulfide reductase
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 5962026..5963021
- synteny block?: BlockID0046350
- occurrence?: in 100% of 33 strains
iruO : heme-degrading iron utilization reductase [1]
• A crystal structure is available: 5TWC
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2311
08BA02176:
C248_2419
11819-97:
MS7_2390
6850:
RSAU_002210
71193:
ST398NM01_2426
ECT-R 2:
ECTR2_2232
ED133:
SAOV_2419c
ED98:
SAAV_2437
HO 5096 0412:
SAEMRSA15_22730
JH1:
SaurJH1_2442
JH9:
SaurJH9_2396
JKD6008:
SAA6008_02410
JKD6159:
SAA6159_02276
LGA251:
SARLGA251_21580
M013:
M013TW_2333
MRSA252:
SAR2461
MSHR1132:
SAMSHR1132_22010
MSSA476:
SAS2264
Mu3:
SAHV_2356
Mu50:
SAV2372
MW2:
MW2294
RF122:
SAB2252c
ST398:
SAPIG2426
T0131:
SAT0131_02562 (ftsZ)
TCH60:
HMPREF0772_10816 (trxB)
TW20:
SATW20_25040
USA300_TCH1516:
USA300HOU_2355 (trxB2)
VC40:
SAVC_10730
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKDVTIIGGGPSGLYASFYAGLRDMSVRLIDVQSELGGKMRIYPEKIIWDIGGIAPKPCH
N315 -------------MYASFYAGLRDMSVRLIDVQSELGGKMRIYPEKIIWDIGGIAPKPCH
NCTC8325 MKDVTIIGGGPSGLYASFYAGLRDMSVRLIDVQSELGGKMRIYPEKIIWDIGGIAPKPCH
Newman MKDVTIIGGGPSGLYASFYAGLRDMSVRLIDVQSELGGKMRIYPEKIIWDIGGIAPKPCH
USA300_FPR3757 MKDVTIIGGGPSGLYASFYAGLRDMSVRLIDVQSELGGKMRIYPEKIIWDIGGIAPKPCH
:**********************************************
COL EILKDTIKQGLYFKPEVHLNERVVDIRKKAERHFEVETEAGEIYTSKAVIIAIGAGIINP
N315 EILKDTIKQGLYFKPEVHLNERVVDIRKKAERHFEVETEAGEIYTSKAVIIAIGAGIINP
NCTC8325 EILKDTIKQGLYFKPEVHLNERVVDIRKKAERHFEVETEAGEIYTSKAVIIAIGAGIINP
Newman EILKDTIKQGLYFKPEVHLNERVVDIRKKAERHFEVETEAGEIYTSKAVIIAIGAGIINP
USA300_FPR3757 EILKDTIKQGLYFKPEVHLNERVVDIRKKAERHFEVETEAGEIYTSKAVIIAIGAGIINP
************************************************************
COL KQLDVKGVERYQLTNLHYVVQSYRRFKDKDVLISGGGNTALDWAHDIAKIAKSVTVVYRK
N315 KQLDVKGVERYQLTNLHYVVQSYRRFKDKDVLISGGGNTALDWAHDIAKIAKSVTVVYRK
NCTC8325 KQLDVKGVERYQLTNLHYVVQSYRRFKDKDVLISGGGNTALDWAHDIAKIAKSVTVVYRK
Newman KQLDVKGVERYQLTNLHYVVQSYRRFKDKDVLISGGGNTALDWAHDIAKIAKSVTVVYRK
USA300_FPR3757 KQLDVKGVERYQLTNLHYVVQSYRRFKDKDVLISGGGNTALDWAHDIAKIAKSVTVVYRK
************************************************************
COL EDVSGHEAMKTLVTDLNVKLCPKTRIKYLVGNDDETHISEVVLEHVESGDRHTVKFDDVI
N315 EDVSGHEAMKTLVTDLNVKLCPKTRIKYLVGNDDETHISEVVLEHVESGDRHTVKFDDVI
NCTC8325 EDVSGHEAMKTLVTDLNVKLCPKTRIKYLVGNDDETHISEVVLEHVESGDRHTVKFDDVI
Newman EDVSGHEAMKTLVTDLNVKLCPKTRIKYLVGNDDETHISEVVLEHVESGDRHTVKFDDVI
USA300_FPR3757 EDVSGHEAMKTLVTDLNVKLCPKTRIKYLVGNDDETHISEVVLEHVESGDRHTVKFDDVI
************************************************************
COL ISHGFDRCNTLLSETSSKLDMHDDCRVKGFGNTTTSIPGIYACGDIVYHDAKSHLIASAF
N315 ISHGFDRCNTLLSETSSKLDMHDDCRVKGFGNTTTSIPGIYACGDIVYHDAKSHLIASAF
NCTC8325 ISHGFDRCNTLLSETSSKLDMHDDCRVKGFGNTTTSIPGIYACGDIVYHDAKSHLIASAF
Newman ISHGFDRCNTLLSETSSKLDMHDDCRVKGFGNTTTSIPGIYACGDIVYHDAKSHLIASAF
USA300_FPR3757 ISHGFDRCNTLLSETSSKLDMHDDCRVKGFGNTTTSIPGIYACGDIVYHDAKSHLIASAF
************************************************************
COL SDGANAANLAKTYIQPDANAEGYVSSHHEVFKEANKTIVNKHLY
N315 SDGANAANLAKTYIQPDANAEGYVSSHHEVFKEANKTIVNKHLY
NCTC8325 SDGANAANLAKTYIQPDANAEGYVSSHHEVFKEANKTIVNKHLY
Newman SDGANAANLAKTYIQPDANAEGYVSSHHEVFKEANKTIVNKHLY
USA300_FPR3757 SDGANAANLAKTYIQPDANAEGYVSSHHEVFKEANKTIVNKHLY
********************************************
- ↑ Slade A Loutet, Marek J Kobylarz, Crystal H T Chau, Michael E P Murphy
IruO is a reductase for heme degradation by IsdI and IsdG proteins in Staphylococcus aureus.
J Biol Chem: 2013, 288(36);25749-59
[PubMed:23893407] [WorldCat.org] [DOI] (I p)Marek J Kobylarz, Graham A Heieis, Slade A Loutet, Michael E P Murphy
Iron Uptake Oxidoreductase (IruO) Uses a Flavin Adenine Dinucleotide Semiquinone Intermediate for Iron-Siderophore Reduction.
ACS Chem Biol: 2017, 12(7);1778-1786
[PubMed:28463500] [WorldCat.org] [DOI] (I p)