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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005939000
- symbol?: —
- synonym:
- description?: Txe/YoeB family addiction module toxin
- Txe/YoeB family addiction module toxin
- addiction module antitoxin
- addiction module toxin Txe/YoeB family protein
- toxin Txe-like protein
- addiction module, toxin
- pseudogene
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 6005971..6006237
- synteny block?: BlockID0046830
- occurrence?: in 91% of 33 strains
yoeB1 (txe1): type II addiction module ribosome-dependent RNase toxin [1]
There is a crystal structure: 6L8G
Under normal conditions, YefM1 sequesters YoeB1 rendering it inert. Under stress conditions, TrfA-augmented ClpCP proteolyzes YefM1, YoeB1 binds to active ribosomes and cleaves messenger RNA transcripts near the start codon resulting in de novo translation shutdown.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2344
08BA02176:
—
11819-97:
MS7_2422
6850:
RSAU_002245
71193:
—
ECT-R 2:
ECTR2_2266
ED133:
SAOV_2453c
ED98:
SAAV_2472
HO 5096 0412:
SAEMRSA15_23060
JH1:
SaurJH1_2479
JH9:
SaurJH9_2431
JKD6008:
SAA6008_02448
JKD6159:
SAA6159_02308
LGA251:
SARLGA251_21890
M013:
M013TW_2368
MRSA252:
SAR2497
MSHR1132:
SAMSHR1132_22350
MSSA476:
SAS2298
Mu3:
SAHV_2391
Mu50:
SAV2407
MW2:
MW2329
RF122:
SAB2287c
ST398:
—
T0131:
SAT0131_02598 (gmk)
TCH60:
HMPREF0772_10780
TW20:
SATW20_25370
USA300_TCH1516:
USA300HOU_2387
VC40:
SAVC_10905
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYY
N315 MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYY
NCTC8325 MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYY
Newman MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYY
USA300_FPR3757 MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYY
**********************:*************************************
COL SRRINHEHRLVYTVDDNHIKIASCKYHY
N315 SRRINHEHRLVYTVDDNHIKIASCKYHY
NCTC8325 SRRINHEHRLVYTVDDNHIKIASCKYHY
Newman SRRINHEHRLVYTVDDNHIKIASCKYHY
USA300_FPR3757 SRRINHEHRLVYTVDDNHIKIASCKYHY
****************************
- ↑ Xinyu Qi, Kimberly M Brothers, Dongzhu Ma, Jonathan B Mandell, Niles P Donegan, Ambrose L Cheung, Anthony R Richardson, Kenneth L Urish
The Staphylococcus aureus toxin-antitoxin system YefM-YoeB is associated with antibiotic tolerance and extracellular dependent biofilm formation.
J Bone Jt Infect: 2021, 6(7);241-253
[PubMed:34262845] [WorldCat.org] [DOI] (P e)Christopher F Schuster, Ralph Bertram
Toxin-Antitoxin Systems of Staphylococcus aureus.
Toxins (Basel): 2016, 8(5);
[PubMed:27164142] [WorldCat.org] [DOI] (I e)Niles P Donegan, Earl T Thompson, Zhibiao Fu, Ambrose L Cheung
Proteolytic regulation of toxin-antitoxin systems by ClpPC in Staphylococcus aureus.
J Bacteriol: 2010, 192(5);1416-22
[PubMed:20038589] [WorldCat.org] [DOI] (I p)