⊟Summary[edit | edit source]

pan ID^?: SAUPAN005990000
symbol^?: kimA
synonym:
description^?: amino acid permease
- amino acid permease
- APC family permease
- membrane protein
- amino acid transporter-like protein
- APC family amino acid-polyamine-organocation transporter
- membrane permease
- truncated amino acid-polyamine-organocation transporter PotE
strand^?: -
coordinates^?: 6051035..6052747
synteny block^?: BlockID0047340
occurrence^?: in 100% of 34 strains

kimA : cyclic di-AMP responsive potassium: proton symporter KimA ^[1]

Bacteria use the second messenger signaling nucleotide cyclic-di-AMP to regulate internal osmotic pressure and maintain balance with both the environment and the cell wall integrity. High cyclic-di-AMP levels repress K⁺ Internalization Membrane protein A (KimA), both allosterically and at the transcriptional level through KtrDE, resulting in reduced potassium import, reduced intracellular potassium and lower turgor pressure.

⊟Orthologs[edit | edit source]

COL:

N315:

NCTC8325:

Newman:

USA300_FPR3757:

04-02981:

SA2981_2377

08BA02176:

C248_2489

11819-97:

MS7_2454

6850:

RSAU_002280

71193:

ST398NM01_2492

ECT-R 2:

ECTR2_2298

ED133:

SAOV_2490c

ED98:

SAAV_2506

HO 5096 0412:

SAEMRSA15_23400

JH1:

SaurJH1_2515

JH9:

SaurJH9_2466

JKD6008:

SAA6008_02481

JKD6159:

SAA6159_02338

JSNZ:

JSNZ_002414

LGA251:

SARLGA251_22210

M013:

M013TW_2403

MRSA252:

SAR2530

MSHR1132:

SAMSHR1132_22680

MSSA476:

SAS2332

Mu3:

SAHV_2424

Mu50:

SAV2440

MW2:

MW2364

RF122:

SAB2322c

ST398:

SAPIG2492

T0131:

SAT0131_02637 (fabD)

TCH60:

HMPREF0772_10748

TW20:

SATW20_25690

USA300_TCH1516:

USA300HOU_2427

VC40:

SAVC_11075 (potE)

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

alignment of orthologues:
CLUSTAL format alignment by MAFFT L-INS-i (v7.307)

COL             MFNQFKRLIIGQPKKNRELKDEKISKFKGLAILSSDALSSVAYGPEQILITLSVVGAVAT
N315            MFNQFKRLIIGQPKKNRELKDEKISKFKGLAILSSDALSSVAYGPEQILITLSVVGAVAT
NCTC8325        MFNQFKRLIIGQPKKNRELKDEKISKFKGLAILSSDALSSVAYGPEQILITLSVVGAVAT
Newman          MFNQFKRLIIGQPKKNRELKDEKISKFKGLAILSSDALSSVAYGPEQILITLSVVGAVAT
USA300_FPR3757  MFNQFKRLIIGQPKKNRELKDEKISKFKGLAILSSDALSSVAYGPEQILITLSVVGAVAT
                ************************************************************

COL             WYTLPIAGAVLILLAALIMSYRQIIYAYPKGGGAYMVSKTNLGEKWGLLAGGSLLVDYIL
N315            WYTLPIAGAVLILLAALIMSYRQIIYAYPKGGGAYMVSKTNLGEKWGLLAGGSLLVDYIL
NCTC8325        WYTLPIAGAVLILLAALIMSYRQIIYAYPKGGGAYMVSKTNLGEKWGLLAGGSLLVDYIL
Newman          WYTLPIAGAVLILLAALIMSYRQIIYAYPKGGGAYMVSKTNLGEKWGLLAGGSLLVDYIL
USA300_FPR3757  WYTLPIAGAVLILLAALIMSYRQIIYAYPKGGGAYMVSKTNLGEKWGLLAGGSLLVDYIL
                ************************************************************

COL             TVAVSISSGADAFVAAFPSLYGHKVLIACLLVLFILILNLRGLTESATVLSYPVYLFIIG
N315            TVAVSISSGADAFVAAFPSLYGHKVLIACLLVLFILILNLRGLTESATVLSYPVYLFIIG
NCTC8325        TVAVSISSGADAFVAAFPSLYGHKVLIACLLVLFILILNLRGLTESATVLSYPVYLFIIG
Newman          TVAVSISSGADAFVAAFPSLYGHKVLIACLLVLFILILNLRGLTESATVLSYPVYLFIIG
USA300_FPR3757  TVAVSISSGADAFVAAFPSLYGHKVLIACLLVLFILILNLRGLTESATVLSYPVYLFIIG
                ************************************************************

COL             LVILIFIGTFRVATGDIQPHMHASVGTAVPGVTLFLLLKAFSSGASSLTGVEAISNAVTN
N315            LVILIFIGTFRVATGDIQPHMHASVGTAVPGVTLFLLLKAFSSGASSLTGVEAISNAVTN
NCTC8325        LVILIFIGTFRVATGDIQPHMHASVGTAVPGVTLFLLLKAFSSGASSLTGVEAISNAVTN
Newman          LVILIFIGTFRVATGDIQPHMHASVGTAVPGVTLFLLLKAFSSGASSLTGVEAISNAVTN
USA300_FPR3757  LVILIFIGTFRVATGDIQPHMHASVGTAVPGVTLFLLLKAFSSGASSLTGVEAISNAVTN
                ************************************************************

COL             FREPSAKNAVKTLIAMGSILAFLLVGIVGLAYVYGILPQTETTVLSQLAMQIFGDNAAFY
N315            FREPSANNAVKTLIAMGSILAFLLVGIVGLAYVYGIMPQTETTVLSQLAMQIFGDNAAFY
NCTC8325        FREPSAKNAVKTLIAMGSILAFLLVGIVGLAYVYGILPQTETTVLSQLAMQIFGDNAAFY
Newman          FREPSAKNAVKTLIAMGSILAFLLVGIVGLAYVYGILPQTETTVLSQLAMQIFGDNAAFY
USA300_FPR3757  FREPSAKNAVKTLIAMGSILAFLLVGIVGLAYVYGILPQTETTVLSQLAMQIFGDNAAFY
                ******:*****************************:***********************

COL             FVQATTVMILVLAANTGFTAFPMLAASMSKDKYMPRMFTVRGDRLGYSNSIIILGVLAII
N315            FVQATTVMILVLAANTGFTAFPMLAASMSKDKYMPRMFTVRGDRLGYSNSIIILGVLAII
NCTC8325        FVQATTVMILVLAANTGFTAFPMLAASMSKDKYMPRMFTVRGDRLGYSNSIIILGVLAII
Newman          FVQATTVMILVLAANTGFTAFPMLAASMSKDKYMPRMFTVRGDRLGYSNSIIILGVLAII
USA300_FPR3757  FVQATTVMILVLAANTGFTAFPMLAASMSKDKYMPRMFTVRGDRLGYSNSIIILGVLAII
                ************************************************************

COL             LIIVFDGMTEDLIPLYAVGVFIPFTLAQFGMVIKWIHERPKNWLSKLSVNLLGGIVTFIV
N315            LIIVFDGMTEDLIPLYAVGVFIPFTLAQFGMVIKWIHERPKNWLSKLSVNLLGGIVTFIV
NCTC8325        LIIVFDGMTEDLIPLYAVGVFIPFTLAQFGMVIKWIHERPKNWLSKLSVNLLGGIVTFIV
Newman          LIIVFDGMTEDLIPLYAVGVFIPFTLAQFGMVIKWIHERPKNWLSKLSVNLLGGIVTFIV
USA300_FPR3757  LIIVFDGMTEDLIPLYAVGVFIPFTLAQFGMVIKWIHERPKNWLSKLSVNLLGGIVTFIV
                ************************************************************

COL             FMILLITKFSQVWPILIFLPFVVIFFLKINKHYRDIAEQLRSDIDVLNVDVVDRNLAIVP
N315            FMILLITKFSQVWPILIFLPFVVIFFLKINKHYRDIAEQLRSDIDVLNVDVVDRNLAIVP
NCTC8325        FMILLITKFSQVWPILIFLPFVVIFFLKINKHYRDIAEQLRSDIDVLNVDVVDRNLAIVP
Newman          FMILLITKFSQVWPILIFLPFVVIFFLKINKHYRDIAEQLRSDIDVLNVDVVDRNLAIVP
USA300_FPR3757  FMILLITKFSQVWPILIFLPFVVIFFLKINKHYRDIAEQLRSDIDVLNVDVVDRNLAIVP
                ************************************************************

COL             ITSITTAVDKSIYYAQMLANNDVIAVHVSFGDEDEKAFQEKWKRHFPDVRLVILHSEYRS
N315            ITSITTAVDKSIYYAQMLANNDVIAVHVSFGDEDEKAFQEKWKRHFPDVRLVILHSEYRS
NCTC8325        ITSITTAVDKSIYYAQMLANNDVIAVHVSFGDEDEKAFQEKWKRHFPDVRLVILHSEYRS
Newman          ITSITTAVDKSIYYAQMLANNDVIAVHVSFGDEDEKAFQEKWKRHFPDVRLVILHSEYRS
USA300_FPR3757  ITSITTAVDKSIYYAQMLANNDVIAVHVSFGDEDEKAFQEKWKRHFPDVRLVILHSEYRS
                ************************************************************

COL             IIRPISRFIDKINRKANDQNYMITVVIPEFITKKRWHNLLHNQTSLRMKLYLIYQKNVNV
N315            IIRPISRFIDKINRKANDQNYMITVVIPEFITKKRWHNLLHNQTSLRMKLYLIYQKNVNV
NCTC8325        IIRPISRFIDKINRKANDQNYMITVVIPEFITKKRWHNLLHNQTSLRMKLYLIYQKNVNV
Newman          IIRPISRFIDKINRKANDQNYMITVVIPEFITKKRWHNLLHNQTSLRMKLYLIYQKNVNV
USA300_FPR3757  IIRPISRFIDKINRKANDQNYMITVVIPEFITKKRWHNLLHNQTSLRMKLYLIYQKNVNV
                ************************************************************

COL             CTIPFKLKK
N315            CTIPFKLKK
NCTC8325        CTIPFKLKK
Newman          CTIPFKLKK
USA300_FPR3757  CTIPFKLKK
                *********

↑ Johannes Gibhardt, Gregor Hoffmann, Asan Turdiev, Mengyi Wang, Vincent T Lee, Fabian M Commichau
c-di-AMP assists osmoadaptation by regulating the Listeria monocytogenes potassium transporters KimA and KtrCD.
J Biol Chem: 2019, 294(44);16020-16033
[PubMed:31506295] [WorldCat.org] [DOI] (I p)Michael F Fuss, Jan-Philip Wieferig, Robin A Corey, Yvonne Hellmich, Igor Tascón, Joana S Sousa, Phillip J Stansfeld, Janet Vonck, Inga Hänelt
Cyclic di-AMP traps proton-coupled K + transporters of the KUP family in an inward-occluded conformation.
Nat Commun: 2023, 14(1);3683
[PubMed:37344476] [WorldCat.org] [DOI] (I e)

[1] Johannes Gibhardt, Gregor Hoffmann, Asan Turdiev, Mengyi Wang, Vincent T Lee, Fabian M Commichau
c-di-AMP assists osmoadaptation by regulating the Listeria monocytogenes potassium transporters KimA and KtrCD.
J Biol Chem: 2019, 294(44);16020-16033
[PubMed:31506295] [WorldCat.org] [DOI] (I p)Michael F Fuss, Jan-Philip Wieferig, Robin A Corey, Yvonne Hellmich, Igor Tascón, Joana S Sousa, Phillip J Stansfeld, Janet Vonck, Inga Hänelt
Cyclic di-AMP traps proton-coupled K + transporters of the KUP family in an inward-occluded conformation.
Nat Commun: 2023, 14(1);3683
[PubMed:37344476] [WorldCat.org] [DOI] (I e)

[1]

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Contents

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

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⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]