Jump to navigation
Jump to search
⊟Summary[edit | edit source]
- pan ID?: SAUPAN006214000
- symbol?: farE
- synonym:
- description?: membrane protein
- membrane protein
- MmpL efflux pump
- antibiotic transport-associated protein-like protein
- fatty acid efflux MMPL transporter FarE
- RND superfamily drug exporter, putative
- Putative antibiotic transport-associated protein
- antibiotic ABC transporter
- membrane protein YdfJ
- membrane transporter
- MMPL domain-containing protein
- mmpl domain protein
- MmpL efflux pump, putative
- MMPL family protein
- MMPL family transporter
- putative transport protein
- resistance-nodulation-cell division acriflavin:proton (H+) antiporter
- RND superfamily resistance-nodulation-cell division:proton (H+) antiporter
- transport protein
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 6275136..6277553
- synteny block?: BlockID0049380
- occurrence?: in 100% of 33 strains
farE: unsaturated fatty acid efflux pump[1]
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2488
08BA02176:
C248_2609
11819-97:
MS7_2558
6850:
RSAU_002393
71193:
ST398NM01_2602
ECT-R 2:
ECTR2_2404
ED133:
SAOV_2596c
ED98:
SAAV_2618
HO 5096 0412:
SAEMRSA15_24550
JH1:
SaurJH1_2628
JH9:
SaurJH9_2574
JKD6008:
SAA6008_02590
JKD6159:
SAA6159_02448
LGA251:
SARLGA251_23270
M013:
M013TW_2525
MRSA252:
SAR2632
MSHR1132:
SAMSHR1132_23720
MSSA476:
SAS2438
Mu3:
SAHV_2536
Mu50:
SAV2552
MW2:
MW2473
RF122:
SAB2426c
ST398:
SAPIG2602
T0131:
SAT0131_02762
TCH60:
HMPREF0772_10639 (ydfJ)
TW20:
SATW20_26740
USA300_TCH1516:
USA300HOU_2546
VC40:
SAVC_11640
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MAKFLYKMGTFIAKHKWSAVIAWIVIVAAILIPLATNAPKFDNDIKMTGLESLDTNKKIE
N315 MAKFLYKMGTFIAKHKWSAVIAWIVIVAAILIPLATNAPKFDNDIKMTGLESLDTNKKIE
NCTC8325 -------MGTFIAKHKWSAVIAWIVIVAAILIPLATNAPKFDNDIKMTGLESLDTNKKIE
Newman MAKFLYKMGTFIAKHKWSAVIAWIVIVAAILIPLATNAPKFDNDIKMTGLESLDTNKKIE
USA300_FPR3757 -------MGTFIAKHKWSAVIAWIVIVAAILIPLATNAPKFDNDIKMTGLESLDTNKKIE
*****************************************************
COL KHFNQDSEKAQIRVVFKTTKDDGIVQPNITKDIKKTLDDIKKDDKHIDKISDPYENKQIS
N315 KHFNQDSEKAQIRVVFKTTKDDGIVQPNITEDIKKTLEDIKKDDKHIDKISDPYENKQIS
NCTC8325 KHFNQDSEKAQIRVVFKTTKDDGIVQPNITKDIKKTLDDIKKDDKHIDKISDPYENKQIS
Newman KHFNQDSEKAQIRVVFKTTKDDGIVQPNITKDIKKTLDDIKKDDKHIDKISDPYENKQIS
USA300_FPR3757 KHFNQDSEKAQIRVVFKTTKDDGIVQPNITKDIKKTLDDIKKDDKHIDKISDPYENKQIS
******************************:******:**********************
COL KDKTTAFADITYDVSQTSLKDGSRDNVKSHLKDLRDNHNVQTELTGTGMTSTEVGGNSEL
N315 KDKTTAFADITYDVSQTSLKDGSRDNVKSHLKDLRDNHNVQTELTGTGMTSTEVGGNSEL
NCTC8325 KDKTTAFADITYDVSQTSLKDGSRDNVKSHLKDLRDNHNVQTELTGTGMTSTEVGGNSEL
Newman KDKTTAFADITYDVSQTSLKDGSRDNVKSHLKDLRDNHNVQTELTGTGMTSTEVGGNSEL
USA300_FPR3757 KDKTTAFADITYDVSQTSLKDGSRDNVKSHLKDLRDNHNVQTELTGTGMTSTEVGGNSEL
************************************************************
COL VGIIVAFVVLLITFGSVIAAGLPIISALIGLASGVGIISLLTYAFDIPNVTLTLAVMIGL
N315 VGIIVAFVVLLITFGSVIAAGLPIISALIGLASGVGIISLLTYAFDIPNVTLTLAVMIGL
NCTC8325 VGIIVAFVVLLITFGSVIAAGLPIISALIGLASGVGIISLLTYAFDIPNVTLTLAVMIGL
Newman VGIIVAFVVLLITFGSVIAAGLPIISALIGLASGVGIISLLTYAFDIPNVTLTLAVMIGL
USA300_FPR3757 VGIIVAFVVLLITFGSVIAAGLPIISALIGLASGVGIISLLTYAFDIPNVTLTLAVMIGL
************************************************************
COL AVGIDYALFILFRYRQVMKTETDYIKGIGLAIGTAGSAVVFAGVTVVIAVCGLSLVGIDF
N315 AVGIDYALFILFRYRQVMKTETDYIKGIGLAIGTAGSAVVFAGVTVVIAVCGLSLVGIDF
NCTC8325 AVGIDYALFILFRYRQVMKTETDYIKGIGLAIGTAGSAVVFAGVTVVIAVCGLSLVGIDF
Newman AVGIDYALFILFRYRQVMKTETDYIKGIGLAIGTAGSAVVFAGVTVVIAVCGLSLVGIDF
USA300_FPR3757 AVGIDYALFILFRYRQVMKTETDYIKGIGLAIGTAGSAVVFAGVTVVIAVCGLSLVGIDF
************************************************************
COL LAVMGFASAISVVFAVLSALTLLPALISIFHKRIKVNKLQSKFKKDIDTPWSKFITGNAL
N315 LAVMGFASAISVIFAVFSALTLLPALISIFHKRIKVNKLQSNFKKDIDTPWSKFITGNAL
NCTC8325 LAVMGFASAISVVFAVLSALTLLPALISIFHKRIKVNKLQSKFKKDIDTPWSKFITGNAL
Newman LAVMGFASAISVVFAVLSALTLLPALISIFHKRIKVNKLQSKFKKDIDTPWSKFITGNAL
USA300_FPR3757 LAVMGFASAISVVFAVLSALTLLPALISIFHKRIKVNKLQSKFKKDIDTPWSKFITGNAL
************:***:************************:******************
COL AAVLLGLIILVAAAIPVSHMRLGIPDDGVKPADSTQKKAYDIISDKFGEGFNGQIPMLIN
N315 AAVLLGLIILVAAAIPVSHMRLGIPDDGVKPADSTQKKAYDIISDKFGEGFNGQIPMLIN
NCTC8325 AAVLLGLIILVAAAIPVSHMRLGIPDDGVKPADSTQKKAYDIISDKFGEGFNGQIPMLIN
Newman AAVLLGLIILVAAAIPVSHMRLGIPDDGVKPADSTQKKAYDIISDKFGEGFNGQIPMLIN
USA300_FPR3757 AAVLLGLIILVAAAIPVSHMRLGIPDDGVKPADSTQKKAYDIISDKFGEGFNGQIPMLIN
************************************************************
COL VKDKKDDPQGLQQDLQSVYKDIKDKKNVDIVTPPQMSKDNDYALMVVIPKQGPNAESTND
N315 VKDKKDDPQGLQQDLQSVYKDIKDKKNVDIVTPPQMSKDNDYALMVVIPKQGPNAESTND
NCTC8325 VKDKKDDPQGLQQDLQSVYKDIKDKKNVDIVTPPQMSKDNDYALMVVIPKQGPNAESTND
Newman VKDKKDDPQGLQQDLQSVYKDIKDKKNVDIVTPPQMSKDNDYALMVVIPKQGPNAESTND
USA300_FPR3757 VKDKKDDPQGLQQDLQSVYKDIKDKKNVDIVTPPQMSKDNDYALMVVIPKQGPNAESTND
************************************************************
COL LVHDLRDYHKDAQDKYGFKTEISGQSVINIDMSKKLNEAIPLFASVIVVLAFFLLMIVFR
N315 LVHDLRDYHKDAQDKYGFKTEISGQSVINIDMSKKLNEAIPLFATVIVVLAFFLLMIVFR
NCTC8325 LVHDLRDYHKDAQDKYGFKTEISGQSVINIDMSKKLNEAIPLFASVIVVLAFFLLMIVFR
Newman LVHDLRDYHKDAQDKYGFKTEISGQSVINIDMSKKLNEAIPLFASVIVVLAFFLLMIVFR
USA300_FPR3757 LVHDLRDYHKDAQDKYGFKTEISGQSVINIDMSKKLNEAIPLFASVIVVLAFFLLMIVFR
********************************************:***************
COL SILIPLKAVLGFVLSLMATLGFTTLVMQDGFMKGLFGIETTGPMLAFLPVITIGILFGLA
N315 SILIPLKAVLGFVLSLMATLGFTTLVMQDGFMKGLFGIETTGPMLAFLPVITIGILFGLA
NCTC8325 SILIPLKAVLGFVLSLMATLGFTTLVMQDGFMKGLFGIETTGPMLAFLPVITIGILFGLA
Newman SILIPLKAVLGFVLSLMATLGFTTLVMQDGFMKGLFGIETTGPMLAFLPVITIGILFGLA
USA300_FPR3757 SILIPLKAVLGFVLSLMATLGFTTLVMQDGFMKGLFGIETTGPMLAFLPVITIGILFGLA
************************************************************
COL MDYEVFLMSRIHEEYSKTGDNDYSIKVGLKESGPVIVAAALIMFSVFFAFVFQEDVMIKS
N315 MDYEVFLMSRIHEEYSKTGDNDYSIKVGLKESGPVIVAAALIMFSVFFAFVFQEDVMIKS
NCTC8325 MDYEVFLMSRIHEEYSKTGDNDYSIKVGLKESGPVIVAAALIMFSVFFAFVFQEDVMIKS
Newman MDYEVFLMSRIHEEYSKTGDNDYSIKVGLKESGPVIVAAALIMFSVFFAFVFQEDVMIKS
USA300_FPR3757 MDYEVFLMSRIHEEYSKTGDNDYSIKVGLKESGPVIVAAALIMFSVFFAFVFQEDVMIKS
************************************************************
COL MGMALAFGVLFDAFVVRMMLIPALTKLFGKGSWYLPAWLNRIIPRVDIEGHALEKYKTVE
N315 MGMALAFGVLFDAFVVRMMLIPALTKLFGKGSWYLPAWLNRIIPRVDIEGHALEKYKTVE
NCTC8325 MGMALAFGVLFDAFVVRMMLIPALTKLFGKGSWYLPAWLNRIIPRVDIEGHALEKYKTVE
Newman MGMALAFGVLFDAFVVRMMLIPALTKLFGKGSWYLPAWLNRIIPRVDIEGHALEKYKTVE
USA300_FPR3757 MGMALAFGVLFDAFVVRMMLIPALTKLFGKGSWYLPAWLNRIIPRVDIEGHALEKYKTVE
************************************************************
COL SQESEAKDSKETYDTTFKVYPQGATNVSKHQDAHGQDDAHSIVLDDKTMALYQEVKQQSA
N315 SQESEAKDSKETYDTTFKVYPQGATNVSKHQDVHGQDDAHSIVLDDKTMALYQEVKQQSA
NCTC8325 SQESEAKDSKETYDTTFKVYPQGATNVSKHQDAHGQDDAHSIVLDDKTMALYQEVKQQSA
Newman SQESEAKDSKETYDTTFKVYPQGATNVSKHQDAHGQDDAHSIVLDDKTMALYQEVKQQSA
USA300_FPR3757 SQESEAKDSKETYDTTFKVYPQGATNVSKHQDAHGQDDAHSIVLDDKTMALYQEVKQQSA
********************************.***************************
COL SSLFLYDALIDYQNKHQLNSKQQATNIEQLNKNIEKLNQLLEKNLRNKS
N315 SSLFLYDALIDYQNKHQLNSKQQVTNIEQLNKNIEKLNQLLEKNLRNKS
NCTC8325 SSLFLYDALIDYQNKHQLNSKQQATNIEQLNKNIEKLNQLLEKNLRNKS
Newman SSLFLYDALIDYQNKHQLNSKQQATNIEQLNKNIEKLNQLLEKNLRNKS
USA300_FPR3757 SSLFLYDALIDYQNKHQLNSKKQATNIEQLNKNIEKLNQLLEKNLRNKS
*********************:*.*************************
- ↑ Heba Alnaseri, Robert C Kuiack, Katherine A Ferguson, James E T Schneider, David E Heinrichs, Martin J McGavin
DNA Binding and Sensor Specificity of FarR, a Novel TetR Family Regulator Required for Induction of the Fatty Acid Efflux Pump FarE in Staphylococcus aureus.
J Bacteriol: 2019, 201(3);
[PubMed:30455282] [WorldCat.org] [DOI] (I e)