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NCBI: 10-JUN-2013

Summary[edit | edit source]

  • organism: Staphylococcus aureus USA300_FPR3757
  • locus tag: SAUSA300_2416 [new locus tag: SAUSA300_RS13375 ]
  • pan locus tag?: SAUPAN006035000
  • symbol: SAUSA300_2416
  • pan gene symbol?:
  • synonym:
  • product: glucose 1-dehydrogenase-like protein

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: SAUSA300_2416 [new locus tag: SAUSA300_RS13375 ]
  • symbol: SAUSA300_2416
  • product: glucose 1-dehydrogenase-like protein
  • replicon: chromosome
  • strand: -
  • coordinates: 2601933..2602652
  • length: 720
  • essential: unknown other strains

Accession numbers[edit | edit source]

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    TTGGCGGTAGACATAGCTGAAGCGGTATCGGAGACTGTCGATAAAATTAAAAGTAATGGT
    GACAATGCGAAGGCGTATAATGTGGATAATGCAAGCGAACAACAAGTGGTAGACTTTGTG
    TCTGACATAAAGGAACAGTTTGGAAGAATCGATGTGTTGTTTAATAATGCCGGTGTGGAT
    AATGCGGCTGATAGAATTCATGAGTATCCAATAGATGTGTATGACAAGATTATGAATGTA
    GATATGCGTGGGACATTTTTAATGACGAAAATGATGTTACCTTTAATGATGAATCAAGGT
    GGCTCTATTGTTAATACGTCTTCATTTTCCGGACAAGCAGCAGACTTGTATCGCTCTGGA
    TATAATGCTGCGAAAGGTGCAGTGATTAATTTTACAAAATCAATCGCAATTGAGTATGGC
    CGTGATAGCATTCGAGCCAATGCGATTGCACCAGGTACAATTGAAACCCCGTTAGTAGAT
    AAACTGACAGGTACGAGTGAGGATGATGCAGGTAAAACATTTAGAGAAAATCAAAAATGG
    ATGACTCCGCTGGGACGTTTAGGTAAACCAGAAGAAGTTGCTAAATTAGTAGTCTTCTTA
    GCATCTGACGACAGTTCATTCATAACTGGAGAGACGATTCGAATTGATGGTGGTGTGATG
    GCTTACACATGGCCTGGCGAGATGTTAAGTGATGATTCGTGGAAGCGGACATTGGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: SAUSA300_2416 [new locus tag: SAUSA300_RS13375 ]
  • symbol: SAUSA300_2416
  • description: glucose 1-dehydrogenase-like protein
  • length: 239
  • theoretical pI: 4.3468
  • theoretical MW: 26189.3
  • GRAVY: -0.277406

Function[edit | edit source]

  • reaction:
    EC 1.1.1.47?  ExPASy
    Glucose 1-dehydrogenase (NAD(P)+) D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H
  • TIGRFAM:
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase (TIGR01830; EC 1.1.1.100; HMM-score: 166.6)
    Unknown function Enzymes of unknown specificity SDR family mycofactocin-dependent oxidoreductase (TIGR03971; EC 1.1.99.-; HMM-score: 155.3)
    3-hydroxybutyrate dehydrogenase (TIGR01963; HMM-score: 150.5)
    Metabolism Energy metabolism Fermentation acetoin reductases (TIGR02415; EC 1.1.1.-; HMM-score: 134.9)
    2-hydroxycyclohexanecarboxyl-CoA dehydrogenase (TIGR03206; EC 1.1.1.-; HMM-score: 134.8)
    acetoacetyl-CoA reductase (TIGR01829; EC 1.1.1.36; HMM-score: 133.8)
    and 8 more
    2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (TIGR04316; EC 1.3.1.28; HMM-score: 127)
    Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides 2-deoxy-D-gluconate 3-dehydrogenase (TIGR01832; EC 1.1.1.125; HMM-score: 126.4)
    Unknown function Enzymes of unknown specificity SDR family mycofactocin-dependent oxidoreductase (TIGR04504; EC 1.1.99.-; HMM-score: 98.4)
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis putative 3-oxoacyl-(acyl-carrier-protein) reductase (TIGR01831; HMM-score: 92.6)
    rhamnulose-1-phosphate aldolase/alcohol dehydrogenase (TIGR02632; EC 1.1.1.1,4.1.2.19; HMM-score: 77.8)
    cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase (TIGR03325; EC 1.3.1.56; HMM-score: 67)
    pteridine reductase (TIGR02685; EC 1.5.1.33; HMM-score: 53.4)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll light-dependent protochlorophyllide reductase (TIGR01289; EC 1.3.1.33; HMM-score: 13.3)
  • TheSEED  :
    • 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100)
    Fatty Acids, Lipids, and Isoprenoids Fatty acids Fatty Acid Biosynthesis FASII  3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100)
  • PFAM:
    NADP_Rossmann (CL0063) adh_short_C2; Enoyl-(Acyl carrier protein) reductase (PF13561; HMM-score: 202.7)
    and 2 more
    adh_short; short chain dehydrogenase (PF00106; HMM-score: 135.5)
    KR; KR domain (PF08659; HMM-score: 24.1)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular possibility: 1
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.008699
    • TAT(Tat/SPI): 0.000437
    • LIPO(Sec/SPII): 0.001715
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit | edit source]

Protein sequence[edit | edit source]

  • MAVDIAEAVSETVDKIKSNGDNAKAYNVDNASEQQVVDFVSDIKEQFGRIDVLFNNAGVDNAADRIHEYPIDVYDKIMNVDMRGTFLMTKMMLPLMMNQGGSIVNTSSFSGQAADLYRSGYNAAKGAVINFTKSIAIEYGRDSIRANAIAPGTIETPLVDKLTGTSEDDAGKTFRENQKWMTPLGRLGKPEEVAKLVVFLASDDSSFITGETIRIDGGVMAYTWPGEMLSDDSWKRTLE

Experimental data[edit | edit source]

  • experimentally validated:
  • protein localization:
  • quantitative data / protein copy number per cell:
  • interaction partners:

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

  • regulator: CodY (repression) regulon
    CodY(TF)important in Amino acid metabolism; RegPrecise 

Transcription pattern[edit | edit source]

Protein synthesis (provided by Aureolib)[edit | edit source]

Protein stability[edit | edit source]

  • half-life: no data available

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

Relevant publications[edit | edit source]