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NCBI: 02-MAR-2017

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus N315
  • locus tag: SA_RS12435 [old locus tag: SA2165 ]
  • pan locus tag?: SAUPAN005895000
  • symbol: SA_RS12435
  • pan gene symbol?: —
  • synonym:
  • product: TetR/AcrR family transcriptional regulator

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SA_RS12435 [old locus tag: SA2165 ]
  • symbol: SA_RS12435
  • product: TetR/AcrR family transcriptional regulator
  • replicon: chromosome
  • strand: +
  • coordinates: 2432143..2432766
  • length: 624
  • essential: no DEG other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_002745 (2432143..2432766) NCBI
  • BioCyc: SA_RS12435 BioCyc
  • MicrobesOnline: see SA2165

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    TTGAAAGAAGATAGGCGAATTAGAAAGACAAAGTCCTCCATTAAACAAGCGTTCACTAAA
    TTACTACAAGAAAAAGATTTAGAAAAGATTACCATTCGCGACATAACAACACGCGCTGAT
    ATCAATAGAGGGACATTTTACTTACATTACGAGGATAAATATATGTTACTCGCAGATATG
    GAAGATGAGTATATTTCAGAACTAACGACATATACTCAATTTGATTTGTTACGCGGTTCT
    TCAATTGAAGACATTGCGAATACTTTTGTAAATAATATACTCAAAAATATTTTCCAACAT
    ATTCATGATAATTTAGAGTTTTATCATACTATTTTACAATTGGAACGCACGAGTCAATTA
    GAATTGAAAATCAACGAACATATCAAAAATAATATGCAACGTTATATTAGTATCAATCAT
    TCTATCGGAGGCGTTCCAGAGATGTATTTTTACAGTTACGTTTCCGGAGCAACAATTTCA
    ATTATTAAATACTGGGTAATGGACAAACAGCCCATTTCAGTTGATGAATTAGCTAAACAT
    GTGCATAATATTATTTTTAATGGTCCATTAAGAATAATGGCAGAAAACCGTTTGCATAAA
    TCAAACCTTGATTCACTAACTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    624

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SA_RS12435 [old locus tag: SA2165 ]
  • symbol: SA_RS12435
  • description: TetR/AcrR family transcriptional regulator
  • length: 207
  • theoretical pI: 7.04064
  • theoretical MW: 24477.8
  • GRAVY: -0.450242

⊟Function[edit | edit source]

  • TIGRFAM:
    probable dihydroxyacetone kinase regulator (TIGR02366; HMM-score: 54.6)
    and 3 more
    Signal transduction Regulatory functions DNA interactions mycofactocin system transcriptional regulator (TIGR03968; HMM-score: 16.7)
    Signal transduction Regulatory functions DNA interactions transcriptional repressor BetI (TIGR03384; HMM-score: 16.6)
    conserved hypothetical protein (TIGR03492; HMM-score: 12)
  • TheSEED: see SA2165
  • PFAM:
    no clan defined TetR_C_8; Transcriptional regulator C-terminal region (PF14278; HMM-score: 54.8)
    and 4 more
    HTH (CL0123) TetR_N; Bacterial regulatory proteins, tetR family (PF00440; HMM-score: 31.1)
    HTH_Tnp_1_2; Helix-turn-helix of insertion element transposase (PF13022; HMM-score: 15.7)
    Glyoxalase (CL0104) Glyoxalase; Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily (PF00903; HMM-score: 13.1)
    TetR_C (CL0174) TetR_C_4; YsiA-like protein, C-terminal region (PF08359; HMM-score: 10)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002891
    • TAT(Tat/SPI): 0.000355
    • LIPO(Sec/SPII): 0.000452
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKEDRRIRKTKSSIKQAFTKLLQEKDLEKITIRDITTRADINRGTFYLHYEDKYMLLADMEDEYISELTTYTQFDLLRGSSIEDIANTFVNNILKNIFQHIHDNLEFYHTILQLERTSQLELKINEHIKNNMQRYISINHSIGGVPEMYFYSYVSGATISIIKYWVMDKQPISVDELAKHVHNIIFNGPLRIMAENRLHKSNLDSLT

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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