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NCBI: 02-MAR-2017

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus N315
  • locus tag: SA_RS13075 [old locus tag: SA2279 ]
  • pan locus tag?: SAUPAN006091000
  • symbol: SA_RS13075
  • pan gene symbol?: pgcA
  • synonym:
  • product: phosphoglucomutase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SA_RS13075 [old locus tag: SA2279 ]
  • symbol: SA_RS13075
  • product: phosphoglucomutase
  • replicon: chromosome
  • strand: +
  • coordinates: 2554995..2556803
  • length: 1809
  • essential: yes [1] DEG other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_002745 (2554995..2556803) NCBI
  • BioCyc: SA_RS13075 BioCyc
  • MicrobesOnline: see SA2279

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    ATGCATTTTCATACACATCTATTATATAATACTTGTGAAAAGTATTGTCTTGGGGCTGTG
    TTTTTTTACTTTTGGGGCGTATTTCTTTATAATTCATTACATAAATGTAAGGGCTTTAGT
    TTTCATGTTTTATTAAGTCTAACTGAGATTTTGAAAGGATGTTTAGCAACAATGGATAAA
    GAATTATGGATAGAAAGAGCTAATGATAGTTTAGTTAAACATTTTTATGAGCAGCAATCT
    GACATTGAACAGCGAGAAGGTTTTGAAAGTAAATTAACATTTGGTACTGCGGGTATACGC
    GGAAAATTCGGTCTTGGTGAAGGTCGACTTAATAAGTTTACTATTGAAAAATTGGCATTA
    GGTTTAGCGCGTTATTTAAATGCCCAAACAAACAGTCCAACAATAGTCATTCATTATGAT
    ATTAGACATCTTTCAACTGAATTCGCCCAAATTATTGCTAATGTATTAGCAAACCATCAA
    ATAACAGTTTATTTACCTGATACATATAAAACGACACCGGAATTATCGTTCGCGGTTCGC
    AATCTTAATACTACTGCCGGCATTATGATTACAGCAAGTCATAATCCGAAAGACTATAAC
    GGCATTAAAGTATATGGTTCTGATGGCGCGCAATTATCGACTGATGCATCTGAGCTTGCA
    AGTCGTTATATCGAAGAAGTTGGCGATCCATTACAGATTGATATACCTATTTCAAAACAA
    AATACATCTTATATCAAACCTTTTCCGAAATCTGTAACTGATGACTATATGAAACACATT
    CAAAATATGATTGGCTATATTCCTAAATCTGATTTACAAGTTGTGTTCACTAGTTTGCAT
    GGTACAAGTGTTCCAATTGTACCTGAGTTATTAAAATCTTTGAATTTCAATCAATTTAAT
    CTTGTAGATGCACAATGTAAACCTGATCCGAATTTTAGTTCAGTTCAAAGTGCTAATCCT
    GAAGATCATCGCGCTTTTGATCAAGCAGTCGAACTTGCAAATAAAAGTCATGCAGACTTA
    TTAATATCAACTGACCCAGATGCAGATCGACTTGGTATTGCTGAACGTGATGCACATGGT
    CATATCACATATTTTAATGGCAACCAAATTGGTGCGCTGTTACTTAATTATCGTATTCAA
    CAAACGTCTCAATTACGTCACCGCTTAATGATTCAATCTATTGTAAGTAGTGAGTTAACA
    AAGTCATTAGCACGCTATAATAATGTTAAATACAAAGAGGTACTGACGGGCTTTAAATTT
    ATTGCTCAGGAAATAAGACAACTGGATGATCATCAAAATATGATTTTCGCATTTGAAGAG
    AGTTACGGTTTTCTATCAGAGCCTTTTGTACGTGATAAAGATGCCGTACAAATTGTGCCA
    CTCATTATAAAATACGCTTCTGAGTTAAAATTATATGGCAAAACATTGAAAGATGAATTA
    GAACAGATTTATCAAACTGTTGGTAGACATGAGGATACATTATTCTCGCATACGCTAGAA
    GGATTAGAAGGTAAGAAAAAAATTGAATCAATTATGACACATTTCCGTTCAAATCCACCG
    CAAGAGATTCAAGGACTGAAAGTGAAAGCAATTGAAGATTATTTAACTAGCGAGGTTTAT
    CATTTGGATAAAGATACAACGTCACAGATTAATTCTTCTAAATCAAATGTTATTCGTGTC
    TTATTTGACGAAGGATTTATCGCTTTACGTCCTTCTGGTACTGAACCTAAAATTAAATTA
    TATGTGTCGTTAAAATGTCCGGATTTTGATGATGTAGCTCAAAAAATTAATGCGATGATT
    TTTAGCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1809

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SA_RS13075 [old locus tag: SA2279 ]
  • symbol: SA_RS13075
  • description: phosphoglucomutase
  • length: 602
  • theoretical pI: 6.58718
  • theoretical MW: 68329.3
  • GRAVY: -0.277076

⊟Function[edit | edit source]

  • reaction:
    EC 5.4.2.2?  ExPASy
    Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate
  • TIGRFAM:
    Metabolism Central intermediary metabolism Amino sugars phosphoglucosamine mutase (TIGR03990; EC 5.4.2.10; HMM-score: 171.5)
    and 3 more
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan phosphoglucosamine mutase (TIGR01455; EC 5.4.2.10; HMM-score: 98)
    Metabolism Central intermediary metabolism Amino sugars phosphoglucosamine mutase (TIGR01455; EC 5.4.2.10; HMM-score: 98)
    Metabolism Energy metabolism Sugars phosphoglucomutase, alpha-D-glucose phosphate-specific (TIGR01132; EC 5.4.2.2; HMM-score: 74.5)
  • TheSEED: see SA2279
  • PFAM:
    no clan defined PGM_PMM_I; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I (PF02878; HMM-score: 142.1)
    and 5 more
    PGM_PMM_II; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II (PF02879; HMM-score: 92.3)
    PGM_PMM_III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III (PF02880; HMM-score: 57)
    PGM_PMM_IV; Phosphoglucomutase/phosphomannomutase, C-terminal domain (PF00408; HMM-score: 31.8)
    Peptidase_MH (CL0035) Amidase_3; N-acetylmuramoyl-L-alanine amidase (PF01520; HMM-score: 12.7)
    no clan defined PPP4R2; PPP4R2 (PF09184; HMM-score: 12.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors: Mg2+
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.02324
    • TAT(Tat/SPI): 0.000711
    • LIPO(Sec/SPII): 0.005581
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MHFHTHLLYNTCEKYCLGAVFFYFWGVFLYNSLHKCKGFSFHVLLSLTEILKGCLATMDKELWIERANDSLVKHFYEQQSDIEQREGFESKLTFGTAGIRGKFGLGEGRLNKFTIEKLALGLARYLNAQTNSPTIVIHYDIRHLSTEFAQIIANVLANHQITVYLPDTYKTTPELSFAVRNLNTTAGIMITASHNPKDYNGIKVYGSDGAQLSTDASELASRYIEEVGDPLQIDIPISKQNTSYIKPFPKSVTDDYMKHIQNMIGYIPKSDLQVVFTSLHGTSVPIVPELLKSLNFNQFNLVDAQCKPDPNFSSVQSANPEDHRAFDQAVELANKSHADLLISTDPDADRLGIAERDAHGHITYFNGNQIGALLLNYRIQQTSQLRHRLMIQSIVSSELTKSLARYNNVKYKEVLTGFKFIAQEIRQLDDHQNMIFAFEESYGFLSEPFVRDKDAVQIVPLIIKYASELKLYGKTLKDELEQIYQTVGRHEDTLFSHTLEGLEGKKKIESIMTHFRSNPPQEIQGLKVKAIEDYLTSEVYHLDKDTTSQINSSKSNVIRVLFDEGFIALRPSGTEPKIKLYVSLKCPDFDDVAQKINAMIFS

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ R Allyn Forsyth, Robert J Haselbeck, Kari L Ohlsen, Robert T Yamamoto, Howard Xu, John D Trawick, Daniel Wall, Liangsu Wang, Vickie Brown-Driver, Jamie M Froelich, Kedar G C, Paula King, Melissa McCarthy, Cheryl Malone, Brian Misiner, David Robbins, Zehui Tan, Zhan-yang Zhu Zy, Grant Carr, Deborah A Mosca, Carlos Zamudio, J Gordon Foulkes, Judith W Zyskind
    A genome-wide strategy for the identification of essential genes in Staphylococcus aureus.
    Mol Microbiol: 2002, 43(6);1387-400
    [PubMed:11952893] [WorldCat.org] [DOI] (P p)

⊟Relevant publications[edit | edit source]

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