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NCBI: 06-JUL-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_0391 [new locus tag: NWMN_RS02210 ]
  • pan locus tag?: SAUPAN002107000
  • symbol: set4nm
  • pan gene symbol?: ssl4
  • synonym:
  • product: superantigen-like protein

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: NWMN_0391 [new locus tag: NWMN_RS02210 ]
  • symbol: set4nm
  • product: superantigen-like protein
  • replicon: chromosome
  • strand: +
  • coordinates: 439407..440333
  • length: 927
  • essential: unknown other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGAAAATAACAACGATTGCTAAAACAAGTTTAGCACTAGGCCTTTTAACAACAGGTGTA
    ATCACAACGACAACGCAAGCAGCAAACGCGACAACACCATCTTCCACTAAAGTGGAAGCA
    CCACAATCAACACCGCCCTCAACTAAAATAGAAGCACCGCAATCAAAACCAAACGCGACA
    ACACCGCCCTCAACTAAAGTAGAAGCACCGCAACAAACAGCAAATGCGACAACACCGCCT
    TCAACTAAAGTGACAACACCTCCATCAACAAACACGCCACAACCAATGCAATCTACTAAA
    TCAGACACACCACAATCGCCAACCACAAAACAAGTACCAACAGAAATAAATCCTAAATTT
    AAAGATTTAAGAGCGTATTATACGAAACCAAGTTTAGAATTTAAAAATGAGATTGGTATT
    ATTTTAAAAAAATGGACGACAATAAGATTTATGAATGTTGTCCCAGATTATTTCATATAT
    AAAATTGCTTTAGTTGGTAAAGATGATAAAAAATATGGTGAAGGAGTACATAGGAATGTC
    GATGTATTTGTCGTTTTAGAAGAAAATAATTACAATCTGGAAAAATATTCTGTCGGTGGT
    ATCACAAAGAGTAATAGTAAAAAAGTTGATCACAAAGCAGGAGTAAGAATTACTAAGGAA
    GATAATAAAGGTACAATCTCTCATGATGTTTCAGAATTCAAGATTACTAAAGAACAGATT
    TCCTTGAAAGAACTTGATTTTAAATTGAGAAAACAACTTATTGAAAAAAATAATCTGTAC
    GGTAACGTTGGTTCAGGTAAAATTGTTATTAAAATGAAAAACGGTGGAAAGTACACGTTT
    GAATTGCACAAAAAATTACAAGAAAATCGCATGGCAGATGTCATAGATGGCACTAATATT
    GATAACATTGAAGTGAATATAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    927

Protein[edit source | edit]

Protein Data Bank: 4DXF
Protein Data Bank: 4DXG

General[edit source | edit]

  • locus tag: NWMN_0391 [new locus tag: NWMN_RS02210 ]
  • symbol: Set4nm
  • description: superantigen-like protein
  • length: 308
  • theoretical pI: 10.2076
  • theoretical MW: 34055.7
  • GRAVY: -0.638312

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
  • TheSEED:  
    Exotoxin 8 
  • PFAM:
    OB_enterotoxin (CL0658) SSL_OB; Staphylococcal superantigen-like OB-fold domain (PF09199; HMM-score: 113.4)
    Ant-toxin_C (CL0386) Stap_Strp_tox_C; Staphylococcal/Streptococcal toxin, beta-grasp domain (PF02876; HMM-score: 31.9)
    no clan definedToxin_10; Insecticidal Crystal Toxin, P42 (PF05431; HMM-score: 12.3)
    Hamartin; Hamartin protein (PF04388; HMM-score: 12.1)
    TPR (CL0020) Suf; Suppressor of forked protein (Suf) (PF05843; HMM-score: 11.8)
    no clan definedTHEG4; Testis highly expressed protein 4 (PF15834; HMM-score: 7.3)
    SOG2; RAM signalling pathway protein (PF10428; HMM-score: 6.7)
    Ndc1_Nup; Nucleoporin protein Ndc1-Nup (PF09531; HMM-score: 6.6)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Extracellular
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0
    • Extracellular Score: 10
    • Internal Helices: 0
  • LocateP: Secretory(released) (with CS)
    • Prediction by SwissProt Classification: Extracellular
    • Pathway Prediction: Sec-(SPI)
    • Intracellular Possibility: -0.17
    • Signal Peptide Possibility: 1
    • N-terminally Anchored Score: -2
    • Predicted Cleavage Site: TQAANATT
  • SignalP: Signal peptide length 31 aa
    • Ymax: 0.777
    • Ymax_pos: 31
    • Cmax: 0.683
    • Cmax_pos: 31
    • Smax: 0.954
    • Smax_pos: 14
    • Smean: 0.91
    • D: 0.829
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit source | edit]

Protein sequence[edit source | edit]

  • MKITTIAKTSLALGLLTTGVITTTTQAANATTPSSTKVEAPQSTPPSTKIEAPQSKPNATTPPSTKVEAPQQTANATTPPSTKVTTPPSTNTPQPMQSTKSDTPQSPTTKQVPTEINPKFKDLRAYYTKPSLEFKNEIGIILKKWTTIRFMNVVPDYFIYKIALVGKDDKKYGEGVHRNVDVFVVLEENNYNLEKYSVGGITKSNSKKVDHKAGVRITKEDNKGTISHDVSEFKITKEQISLKELDFKLRKQLIEKNNLYGNVGSGKIVIKMKNGGKYTFELHKKLQENRMADVIDGTNIDNIEVNIK

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]

Stefan Monecke, Peter Slickers, Ralf Ehricht
Assignment of Staphylococcus aureus isolates to clonal complexes based on microarray analysis and pattern recognition.
FEMS Immunol. Med. Microbiol.: 2008, 53(2);237-51
[PubMed:18507678] [WorldCat.org] [DOI] (P p)