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NCBI: 06-JUL-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_0683 [new locus tag: NWMN_RS03860 ]
  • pan locus tag?: SAUPAN002600000
  • symbol: pabB
  • pan gene symbol?: pabB
  • synonym:
  • product: anthranilate/para-aminobenzoate synthase component I

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: NWMN_0683 [new locus tag: NWMN_RS03860 ]
  • symbol: pabB
  • product: anthranilate/para-aminobenzoate synthase component I
  • replicon: chromosome
  • strand: +
  • coordinates: 763288..764439
  • length: 1152
  • essential: unknown other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    GTGAGAATAGAATATAATTATCGCTACTATTTAACTGAAAATGAATATAAGCAATACCAT
    ATTCAATTAAAGGGATTTATAAAGAAGTATGTTGCTACTAAGTTGGCTGATGTGGGAGAA
    GTGATACACTTTGCACAAGCGCAGCAACGACAAGGTAGATATGTCTCGTTATATTTAAGT
    TACGAAGCGGCAAAGTATTTTAATCATGCTATGTGTACACATTCATTAGCTAAAGATGAT
    ATTTATGCAGCAGCTTATAGTTTTGAAAAAGCGGAAAGCATAAATTCAACATATGAACAT
    CAAACTTCTTATGTATCAAAGTATCATTTTTCATTTGTTGAATCTTCTGAGGTTATGATG
    ACTAATATTAAACGTGTCCAACAAGCAATTGTTGAAGGCGAAACGTATCAAGTGAACTAT
    ACGGCGCGCTTAACGGATAACATTTATTATCCTATTAGTACTTTATATGAACGATTAACT
    CAATTTAGTAATGGTAATTATACTGCGTTATTACAAACTGATGAAATCCAAGTAGCGTCT
    ATCTCACCAGAATTATTTTTTCAAAAAGGACAATTTAACAATGTCGATAACGTTATCATA
    AGCAAACCGATGAAAGGGACAATGCCTAGAGGTAAAACGGAAGCTGAAGATCAACAGTAT
    TATAAAACATTGCAAACTTCTTCGAAAGATCGTGCAGAAAATGTCATGATTGTTGATTTA
    CTAAGAAACGATATAGGGAGAATATCACAGAGTGGCTCAATTAAGGTGTATAAACTATTT
    TTTATTGAGGCATATAAAACTGTATTTCAAATGACTTCGATGGTAAGTGGAACTTTAAAA
    AATAATACAGACTTAACTCAAATTTTAACATCGTTATTTCCTTGTGGTTCGATTACAGGT
    GCACCGAAACTGAATACAATGAAATATATTAAACAATTAGAAAGTTCACCTCGTGGTATA
    TACTGCGGAGCAATTGGACTATTACTTCCAACTGAAGATGATAAAATGATTTTTAATATT
    CCGATTCGCACTATTGAGTATAAATATGGACAAGCGATTTATGGAGTCGGAGCAGGTATT
    ACAATTGATTCTAAGCCAAAAGATGAAGTGAATGAATTTTACGCAAAAACCAAGATTTTG
    GAGATGTTATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1152

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: NWMN_0683 [new locus tag: NWMN_RS03860 ]
  • symbol: PabB
  • description: anthranilate/para-aminobenzoate synthase component I
  • length: 383
  • theoretical pI: 8.30263
  • theoretical MW: 43964.8
  • GRAVY: -0.358225

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
    MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersFolic acidaminodeoxychorismate synthase, component I (TIGR00553; EC 2.6.1.85; HMM-score: 328.3)
    aminodeoxychorismate synthase, component I (TIGR01824; EC 2.6.1.85; HMM-score: 270.6)
    MetabolismAmino acid biosynthesisAromatic amino acid familyanthranilate synthase component I (TIGR00564; EC 4.1.3.27; HMM-score: 223.7)
    MetabolismAmino acid biosynthesisAromatic amino acid familyanthranilate synthase component I (TIGR01820; EC 4.1.3.27; HMM-score: 207.7)
    aminodeoxychorismate synthase (TIGR01823; EC 2.6.1.85; HMM-score: 140.4)
    MetabolismAmino acid biosynthesisAromatic amino acid familyanthranilate synthase component I (TIGR00565; EC 4.1.3.27; HMM-score: 128.6)
    MetabolismAmino acid biosynthesisAromatic amino acid familyanthranilate synthase (TIGR01815; EC 4.1.3.27; HMM-score: 105.5)
    salicylate synthase (TIGR03494; EC 4.1.3.-,5.4.4.2; HMM-score: 96.3)
    MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersMenaquinone and ubiquinoneisochorismate synthase (TIGR00543; EC 5.4.4.2; HMM-score: 93)
    Arabidopsis thaliana cystatin-related protein (TIGR01638; HMM-score: 13)
  • TheSEED:  
    Amino Acids and DerivativesAromatic amino acids and derivativesTryptophan synthesis Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) 
    Cofactors, Vitamins, Prosthetic Groups, PigmentsFolate and pterinesFolate Biosynthesis Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) 
  • PFAM:
    no clan definedChorismate_bind; chorismate binding enzyme (PF00425; HMM-score: 270.4)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular Possibility: 1
    • Signal Peptide Possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • Ymax: 0.125
    • Ymax_pos: 48
    • Cmax: 0.141
    • Cmax_pos: 48
    • Smax: 0.18
    • Smax_pos: 32
    • Smean: 0.11
    • D: 0.119
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit source | edit]

Protein sequence[edit source | edit]

  • MRIEYNYRYYLTENEYKQYHIQLKGFIKKYVATKLADVGEVIHFAQAQQRQGRYVSLYLSYEAAKYFNHAMCTHSLAKDDIYAAAYSFEKAESINSTYEHQTSYVSKYHFSFVESSEVMMTNIKRVQQAIVEGETYQVNYTARLTDNIYYPISTLYERLTQFSNGNYTALLQTDEIQVASISPELFFQKGQFNNVDNVIISKPMKGTMPRGKTEAEDQQYYKTLQTSSKDRAENVMIVDLLRNDIGRISQSGSIKVYKLFFIEAYKTVFQMTSMVSGTLKNNTDLTQILTSLFPCGSITGAPKLNTMKYIKQLESSPRGIYCGAIGLLLPTEDDKMIFNIPIRTIEYKYGQAIYGVGAGITIDSKPKDEVNEFYAKTKILEML

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]