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NCBI: 26-AUG-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus N315
  • locus tag: SA2290 [new locus tag: SA_RS13130 ]
  • pan locus tag?: SAUPAN006097000
  • symbol: fnbB
  • pan gene symbol?: fnbB
  • synonym:
  • product: hypothetical protein

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: SA2290 [new locus tag: SA_RS13130 ]
  • symbol: fnbB
  • product: hypothetical protein
  • replicon: chromosome
  • strand: -
  • coordinates: 2568323..2571208
  • length: 2886
  • essential: no DEG other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    GTGAAAAGCAATCTTAGATACGGCATAAGAAAACACAAATTGGGAGCGGCCTCAGTATTC
    TTAGGAACAATGATCGTTGTTGGAATGGGACAAGAAAAAGAAGCTGCAGCATCGGAACAA
    AACAATACTACAGTAGAGGAAAGTGGGAGTTCAGCTACTGAAAGTAAAGCAAGCGAAACA
    CAAACAACTACAAATAACGTTAATACAATAGATGAAACACAATCATACAGCGCGACATCA
    ACTGAGCAACCATCAAAATCAACTCAAGTAACAACAGAAGAAGCACCAACAACTGTGCAA
    GCACCAAAAGTAGAAACCGAAATGAAATCACAAGAAGATTTACCATCAGAAAAAGTTGCT
    GATAAGGAAACTACAGGAACTCAAGTTGACATAGCTCAACCAAGTAACGTCTCAGAAATT
    AAACCAAGAATGAAAAGATCAGCTGACGTTACAGCAGTTTCAGAGAAAGAAGTAGCGGAA
    GAAGCTAAAGCGACAGGTACAGATGTAACAAATAAAGTGGAAGTTACTGAAAGCTCTTTA
    GAAGGACATAATAAAGATTCGAATATTGTTAATCCGCATAATGCTCAAAGAGTAACTTTA
    AAATACAAATGGAAATTTGGAGAAGGAATTAAGGCAGGAGATTATTTTGATTTCACATTA
    AGTGATAATGTTGAAACACATGGTATATCAACACTGCGTAAAGTTCCGGAGATAAAAAGT
    TCAACAGAAGATAAAGTTATGGCAAATGGTCAAGTTATAAATGAACGTACAATTCGCTAT
    ACATTTACTGATTATATAAATAACAAAAAAGATTTAACTGCTGAATTAAACTTAAACCTA
    TTCATTGACCCAACAACAGTGACAAAGCAAGGGAGTCAAAAAGTTGAAGTAACACTAGGT
    CAAAATAAAGTCTCAAAAGAATTTGATATCAAATATTTAGACGGCGTTAAAGATAGAATG
    GGTGTTACTGTTAATGGTCGTATTGATACTTTGAATAAAGAAGAGGGTAAATTTAGCCAT
    TTTGCATATGTGAAGCCTAACAACCAGTCGTTAACTTCTGTCACAGTAACTGGTCAAGTA
    ACATCTGGATATAAACAAAGTGCTAATAATCCAACAGTCAAAGTATATAAACACATTGGT
    TCAGATGAATTAGCTGAAAGTGTTTATGCAAAGCTTGATGATACCAGTAAATTTGAAGAT
    GTGACTGAAAAAGTAAATCTATCTTACACAAGTAATGGTGGGTACACATTGAACCTTGGC
    GATTTAGATAATTCGAAAGACTATGTAATTAAATATGAAGGTGAATATGATCAAAATGCT
    AAGGATCTAAATTTCCGAACACATCTTTCAGGATATCATAAATACTACCCATACTATCCT
    TATTACCCGTATTATCCAGTTCAATTAACTTGGAACAACGGTGTTGCATTTTACTCTAAT
    AATGCTAAAGGCGATGGTAAAGATAAACCAAATGATCCTATCATTGAGAAGAGTGAACCA
    ATTGATTTAGACATTAAATCAGAGCCACCAGTGGAGAAGCATGAATTGACTGGTACAATC
    GAAGAAAGTAACGATTCTAAGCCAATTGATTTTGAATATCATACAGCTGTTGAAGGTGCA
    GAAGGTCATGCAGAAGGTATTATTGAAACTGAAGAAGATTCTATTCATGTGGATTTTGAA
    GAATCTACACATGAAAATTCAAAACATCACGCTGATGTTGTTGAATATGAAGAGGATACA
    AACCCAGGTGGTGGCCAAGTAACAACTGAGTCTAACTTAGTTGAATTTGACGAAGAGTCT
    ACAAAAGGTATTGTAACTGGCGCAGTGAGCGACCATACAACAGTTGAAGATACGAAAGAA
    TATACAACTGAAAGTAATCTGATTGAATTAGTGGATGAATTACCTGAAGAACATGGTCAA
    GCACAAGGGCCAATCGAGGAAATTACTGAAAACAATCATCATATTTCTCATTCTGGTTTA
    GGAACTGAAAATGGTCACGGTAATTATGGCGTGATTGATGAAATCGAAGAAAATAGCCAC
    GTTGATATTAAGAGTGAATTAGGTTATGAAGGTGGCCAAAATAGCGGTAATCAGTCATTC
    GAGGAAGACACAGAAGAAGATAAACCTAAATATGAACAAGGTGGTAATATCGTAGATATC
    GATTTCGACAGTGTACCTCAAATTCATGGTCAAAATAATGGTAACCAGTCATTCGAGGAA
    GACACAGAAGAAGACAAGCCTAAGTATGAACAAGGTGGTAACATCATTGATATCGACTTC
    GACAGTGTGCCACAAATTCATGGATTCAATAAGCATAATGAAATTATTGAAGAAGATACA
    AACAAAGATAAACCTAATTATCAATTTGGTGGACACAACAGTGTTGATTTTGAAGAAGAT
    ACACTTCCAAAAGTAAGTGGTCAAAATGAAGGTCAACAAACGATTGAAGAAGATACAACG
    CCGCCAACACCGCCAACACCAGAGGTACCAAGTGAGCCGGAAACACCAACACCACCAACA
    CCAGAAGTACCGAGTGAGCCAGGCGAACCAACGCCACCAAAACCGGAAGTACCAAGTGAG
    CCGGAAACACCAGTACCACCAACACCAGAGGTACCATCTGAACCTGGTAAACCAGTACCA
    CCTGCTAAAGAAGAACCTAAAAAACCTTCTAAACCAGTGGAACAAGGTAAGGTAGTAACA
    CCTGTTATTGAAATCAATGAAAAGGTTAAAGCAGTGGCACCAACTAAACAAAAACAATCT
    AAGAAATCTGAACTACCTGAAACAGGTGGAGAAGAATCAACAAACAAAGGTATGTTGTTC
    GGCGGATTATTCAGCATTCTAGGTTTAGTATTATTACGCAGAAATAAAAAGAATAACAAA
    GCATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2700
    2760
    2820
    2880
    2886

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: SA2290 [new locus tag: SA_RS13130 ]
  • symbol: FnbB
  • description: hypothetical protein
  • length: 961
  • theoretical pI: 4.34879
  • theoretical MW: 106010
  • GRAVY: -0.941727

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
    Cell structureCell envelopeOtherLPXTG cell wall anchor domain (TIGR01167; HMM-score: 26.8)
    gram-positive signal peptide, YSIRK family (TIGR01168; HMM-score: 20.8)
  • TheSEED:  
    Virulence, Disease and DefenseAdhesionAdhesins in Staphylococcus Fibronectin binding protein FnbB 
  • PFAM:
    Adhesin (CL0204) SdrG_C_C; C-terminus of bacterial fibrinogen-binding adhesin (PF10425; HMM-score: 125.1)
    no clan definedFn_bind; Fibronectin binding repeat (PF02986; HMM-score: 107.8)
    Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 37)
    YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 31.8)
    Zn_Beta_Ribbon (CL0167) DUF2072; Zn-ribbon containing protein (PF09845; HMM-score: 14.1)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 10
    • Extracellular Score: 0
    • Internal Helices: 0
  • LocateP: LPxTG Cell-wall anchored
    • Prediction by SwissProt Classification: Cell Wall
    • Pathway Prediction: Sec-(SPI)
    • Intracellular Possibility: 0.17
    • Signal Peptide Possibility: 1
    • N-terminally Anchored Score: -2
    • Predicted Cleavage Site: found LPxTG motif :LPETG
  • SignalP: Signal peptide length 37 aa
    • Ymax: 0.665
    • Ymax_pos: 37
    • Cmax: 0.533
    • Cmax_pos: 37
    • Smax: 0.917
    • Smax_pos: 28
    • Smean: 0.797
    • D: 0.717
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit source | edit]

  • GI: 15928081 NCBI
  • RefSeq: NP_375614 NCBI
  • UniProt:

Protein sequence[edit source | edit]

  • MKSNLRYGIRKHKLGAASVFLGTMIVVGMGQEKEAAASEQNNTTVEESGSSATESKASETQTTTNNVNTIDETQSYSATSTEQPSKSTQVTTEEAPTTVQAPKVETEMKSQEDLPSEKVADKETTGTQVDIAQPSNVSEIKPRMKRSADVTAVSEKEVAEEAKATGTDVTNKVEVTESSLEGHNKDSNIVNPHNAQRVTLKYKWKFGEGIKAGDYFDFTLSDNVETHGISTLRKVPEIKSSTEDKVMANGQVINERTIRYTFTDYINNKKDLTAELNLNLFIDPTTVTKQGSQKVEVTLGQNKVSKEFDIKYLDGVKDRMGVTVNGRIDTLNKEEGKFSHFAYVKPNNQSLTSVTVTGQVTSGYKQSANNPTVKVYKHIGSDELAESVYAKLDDTSKFEDVTEKVNLSYTSNGGYTLNLGDLDNSKDYVIKYEGEYDQNAKDLNFRTHLSGYHKYYPYYPYYPYYPVQLTWNNGVAFYSNNAKGDGKDKPNDPIIEKSEPIDLDIKSEPPVEKHELTGTIEESNDSKPIDFEYHTAVEGAEGHAEGIIETEEDSIHVDFEESTHENSKHHADVVEYEEDTNPGGGQVTTESNLVEFDEESTKGIVTGAVSDHTTVEDTKEYTTESNLIELVDELPEEHGQAQGPIEEITENNHHISHSGLGTENGHGNYGVIDEIEENSHVDIKSELGYEGGQNSGNQSFEEDTEEDKPKYEQGGNIVDIDFDSVPQIHGQNNGNQSFEEDTEEDKPKYEQGGNIIDIDFDSVPQIHGFNKHNEIIEEDTNKDKPNYQFGGHNSVDFEEDTLPKVSGQNEGQQTIEEDTTPPTPPTPEVPSEPETPTPPTPEVPSEPGEPTPPKPEVPSEPETPVPPTPEVPSEPGKPVPPAKEEPKKPSKPVEQGKVVTPVIEINEKVKAVAPTKQKQSKKSELPETGGEESTNKGMLFGGLFSILGLVLLRRNKKNNKA

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]

T J Foster, M Höök
Surface protein adhesins of Staphylococcus aureus.
Trends Microbiol.: 1998, 6(12);484-8
[PubMed:10036727] [WorldCat.org] (P p)