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NCBI: 26-AUG-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus N315
  • locus tag: SA2397 [new locus tag: SA_RS13720 ]
  • pan locus tag?: SAUPAN006301000
  • symbol: SA2397
  • pan gene symbol?:
  • synonym:
  • product: 4-aminobutyrate aminotransferase

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: SA2397 [new locus tag: SA_RS13720 ]
  • symbol: SA2397
  • product: 4-aminobutyrate aminotransferase
  • replicon: chromosome
  • strand: -
  • coordinates: 2685873..2687246
  • length: 1374
  • essential: no DEG other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    TTGCACATTAATACTGTCAATGGGAGGGGAATGTATATGAGTAAAGCACATCAATTAATT
    CAAGAGGATGAACATTATTTTGCGAAATCAGGACGTATTAAATATTATCCGTTAGTGATT
    GATCATGGATATGGAGCAACATTGGTTGATATTGAGGGGAAGACATATATCGATTTGTTA
    TCGAGTGCAAGTTCTCAAAACGTAGGTCATGCACCTAGAGAAGTAACAGAAGCGATAAAG
    GCACAAGTTGATAAATTTATTCATTATACACCAGCATATATGTATCATGAACCGTTGGTA
    CGTTTAGCTAAGAAGCTTTGTGAGCTTGCACCTGGAGATTTTGAAAAAAGAGTGACCTTC
    GGATTAACCGGATCAGACGCAAATGATGGCATCATTAAATTTGCCAGAGCATATACAGGG
    CGTCCTTATATCATTAGTTTCACTAATGCATATCATGGTTCAACTTTTGGCTCATTGTCT
    ATGTCAGCTATTAGTTTAAATATGCGCAAACATTATGGTCCGTTATTGAATGGTTTTTAT
    CATATTCCGTTTCCAGATAAATATCGTGGTATGTACGAGCAGCCACAAGCTAATTCAGTA
    GAAGAATATTTAGCACCCTTAAAAGAAATGTTTGCGAAATATGTACCTGCTGACGAAGTA
    GCATGTATTGTTATTGAAACGATACAAGGCGATGGTGGACTTTTAGAACCAGTTCCAGGG
    TATTTTGAAGCGTTAGAAAAGATTTGTCGTGAACATGGTATTTTAATCGCTGTCGATGAT
    ATTCAACAAGGTTTTGGGCGAACAGGTACATGGAGTTCAGTCTCGCATTTTAATTTTACG
    CCTGATTTAATCACTTTCGGAAAATCCTTAGCAGGTGGTATGCCCATGTCAGCAATTGTT
    GGACGCAAAGAGATTATGAATTGTTTAGAAGCACCAGCACATTTATTTACAACAGGTGCT
    AATCCAGTTAGTTGTGAAGCTGCATTAGCCACAATTCAAATGATTGAAGATCAGTCGCTT
    CTTCAGGCTAGTGCGGAAAAAGGGGAATATGTTAGGAAACGAATGGATCAATGGGTATCT
    AAATACAATAGTGTAGGCGATGTTAGAGGTAAAGGTCTGAGCATTGGTATTGATATTGTT
    TCCGACAAAAAACTCAAAACACGTGATGCCAGTGCGGCACTTAAAATTTGTAATTACTGC
    TTTGAGCATGGCGTAGTTATTATAGCTGTAGCAGGAAATGTGTTGCGATTCCAACCGCCA
    TTGGTGATAACATATGAGCAATTAGACACGGCGTTAAACACTATAGAAGATGCACTGACT
    GCTTTGGAAGCAGGTAACTTAGATCAATATGACATATCTGGACAAGGTTGGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1374

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: SA2397 [new locus tag: SA_RS13720 ]
  • symbol: SA2397
  • description: 4-aminobutyrate aminotransferase
  • length: 457
  • theoretical pI: 6.15301
  • theoretical MW: 50456.3
  • GRAVY: -0.128665

Function[edit source | edit]

  • reaction:
    EC 2.6.1.19?  ExPASy
    4-aminobutyrate--2-oxoglutarate transaminase4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate
  • TIGRFAM:
    MetabolismCentral intermediary metabolismOther4-aminobutyrate transaminase (TIGR00700; EC 2.6.1.19; HMM-score: 338.6)
    transaminase, acetylornithine/succinylornithine family (TIGR00707; HMM-score: 300.2)
    MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersBiotinadenosylmethionine-8-amino-7-oxononanoate transaminase (TIGR00508; EC 2.6.1.62; HMM-score: 254.1)
    ornithine--oxo-acid transaminase (TIGR01885; EC 2.6.1.13; HMM-score: 242.6)
    MetabolismCentral intermediary metabolismOther2,4-diaminobutyrate 4-transaminase (TIGR00709; EC 2.6.1.-; HMM-score: 225.8)
    Cellular processesCellular processesAdaptations to atypical conditionsdiaminobutyrate--2-oxoglutarate aminotransferase (TIGR02407; EC 2.6.1.76; HMM-score: 215.9)
    MetabolismEnergy metabolismAmino acids and aminessuccinylornithine transaminase family (TIGR03246; EC 2.6.1.81; HMM-score: 212.3)
    MetabolismCentral intermediary metabolismPolyamine biosynthesisputrescine aminotransferase (TIGR03372; EC 2.6.1.82; HMM-score: 187.1)
    MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersHeme, porphyrin, and cobalaminglutamate-1-semialdehyde-2,1-aminomutase (TIGR00713; EC 5.4.3.8; HMM-score: 167.7)
    L-lysine 6-transaminase (TIGR03251; EC 2.6.1.36; HMM-score: 131.9)
    MetabolismCentral intermediary metabolismOther4-aminobutyrate aminotransferase (TIGR00699; EC 2.6.1.19; HMM-score: 100.4)
    MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersBiotin8-amino-7-oxononanoate synthase (TIGR00858; EC 2.3.1.47; HMM-score: 30.1)
    putative pyridoxal phosphate-dependent acyltransferase (TIGR01825; EC 2.3.1.-; HMM-score: 19.9)
  • TheSEED:  
    aminotransferase 
  • PFAM:
    PLP_aminotran (CL0061) Aminotran_3; Aminotransferase class-III (PF00202; HMM-score: 351.1)
    Aminotran_1_2; Aminotransferase class I and II (PF00155; HMM-score: 13.5)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.67
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.15
    • Extracellular Score: 0.17
    • Internal Helices: 0
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular Possibility: 1
    • Signal Peptide Possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • Ymax: 0.121
    • Ymax_pos: 29
    • Cmax: 0.122
    • Cmax_pos: 29
    • Smax: 0.226
    • Smax_pos: 5
    • Smean: 0.117
    • D: 0.119
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit source | edit]

Protein sequence[edit source | edit]

  • MHINTVNGRGMYMSKAHQLIQEDEHYFAKSGRIKYYPLVIDHGYGATLVDIEGKTYIDLLSSASSQNVGHAPREVTEAIKAQVDKFIHYTPAYMYHEPLVRLAKKLCELAPGDFEKRVTFGLTGSDANDGIIKFARAYTGRPYIISFTNAYHGSTFGSLSMSAISLNMRKHYGPLLNGFYHIPFPDKYRGMYEQPQANSVEEYLAPLKEMFAKYVPADEVACIVIETIQGDGGLLEPVPGYFEALEKICREHGILIAVDDIQQGFGRTGTWSSVSHFNFTPDLITFGKSLAGGMPMSAIVGRKEIMNCLEAPAHLFTTGANPVSCEAALATIQMIEDQSLLQASAEKGEYVRKRMDQWVSKYNSVGDVRGKGLSIGIDIVSDKKLKTRDASAALKICNYCFEHGVVIIAVAGNVLRFQPPLVITYEQLDTALNTIEDALTALEAGNLDQYDISGQGW

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

  • SA2397 no polycistronic organisation predicted

Regulation[edit source | edit]

  • sigma factor:
  • regulator: CodY
    CodY (TF) important in Amino acid metabolismRegPrecise

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]