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NCBI: 10-JUN-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL1124 [new locus tag: SACOL_RS05740 ]
  • pan locus tag?: SAUPAN003342000
  • symbol: ctaA
  • pan gene symbol?: ctaA
  • synonym:
  • product: cytochrome oxidase assembly protein

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: SACOL1124 [new locus tag: SACOL_RS05740 ]
  • symbol: ctaA
  • product: cytochrome oxidase assembly protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1136065..1137135
  • length: 1071
  • essential: unknown other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    ATGTCGTCCACATACAATACTTGTAAAATTAAATCATATTTCCTGCGTTGGATCCCATCT
    TTTCATATCCTACAATCAGGTCTATTTATAGTATCATCTCAAAGCCGGCTATTAATTCTA
    ATTCTCAGTGATGCGTTTTTTTATGATGGGGTGTATAAATTGTTTGGCAAAAAGAATTTA
    AAATGGTTAGGTGTCGTAGCAACGTTAATGATGACATTTGTACAACTTGGTGGAGCCTTA
    GTTACCAAAACCGGATCAGCTGATGGTTGTGGTTCTTCTTGGCCACTATGTCATGGTGCG
    TTGATTCCAGAATTCTTTCCTATTGATACGATTATTGAGTTAAGTCATAGAGCCGTTTCA
    GCTTTGTCTTTATTAATGGTCTTATGGTTAGTTATCACTGCATGGAAACATATAGGCTAT
    ATTAAAGAAATTAAACCTTTATCAATCATTAGTGTTGGATTCTTATTATTGCAAGCATTA
    ATCGGAGCTGCTGCTGTTATTTGGCAACAAAACGATTACGTTTTAGCATTGCACTTTGGT
    ATATCATTAATCAGTTTCTCATCTGTATTTTTAATAACATTGATTATTTTCTCTATAGAT
    CAAAAATATGAAGCTGACGAATTATATATCAAAAAGCCATTAAGACGTTTAACATGGTTA
    ATGGCAATCATCATTTATTGTGGTGTTTATACTGGTGCACTAGTGAGACATGCGGATGCA
    AGTTTAGCATATGGTGGTTGGCCATTGCCATTCCACGATCTTGTACCACATTCAGAACAA
    GATTGGGTTCAACTCACGCATCGTATCATGGCTTTTATAGTGTTTACGATTATTATGATT
    ACTTATATTCACGCTGTTAAAAATTATCCAAATAACCGTACTGTTCATTATGGTTATACA
    GCTGCATTTATACTTGTTATATTACAAGTTATCACAGGTGCATTATCTATTATGACAAAT
    GTTAACCTGATAATCGCACTTTTCCATGCATTATTTATCACTTATTTATTTGGTATGACA
    ACATACTTTATCATGCTAATGTTACGATCAGTAAGAAGTGACAAGCAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1071

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: SACOL1124 [new locus tag: SACOL_RS05740 ]
  • symbol: CtaA
  • description: cytochrome oxidase assembly protein
  • length: 356
  • theoretical pI: 9.42349
  • theoretical MW: 40222.6
  • GRAVY: 0.720506

Function[edit source | edit]

  • reaction:
    EC 1.3.-.-?  ExPASy
  • TIGRFAM:
    methanobactin biosynthesis cassette protein MbnC (TIGR04160; HMM-score: 12.7)
    surface glycoprotein signal peptide (TIGR04207; HMM-score: 11.3)
  • TheSEED:  
    RespirationRespiration - no subcategoryBiogenesis of cytochrome c oxidases Heme A synthase, cytochrome oxidase biogenesis protein Cox15-CtaA 
  • PFAM:
    2heme_cytochrom (CL0328) COX15-CtaA; Cytochrome oxidase assembly protein (PF02628; HMM-score: 115.7)
    no clan definedDUF4231; Protein of unknown function (DUF4231) (PF14015; HMM-score: 9.6)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 9
  • LocateP: Multi-transmembrane
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPI)
    • Intracellular Possibility: 0.17
    • Signal Peptide Possibility: -1
    • N-terminally Anchored Score: -1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • Ymax: 0.151
    • Ymax_pos: 11
    • Cmax: 0.148
    • Cmax_pos: 48
    • Smax: 0.279
    • Smax_pos: 4
    • Smean: 0.214
    • D: 0.175
  • predicted transmembrane helices (TMHMM): 8

Accession numbers[edit source | edit]

Protein sequence[edit source | edit]

  • MSSTYNTCKIKSYFLRWIPSFHILQSGLFIVSSQSRLLILILSDAFFYDGVYKLFGKKNLKWLGVVATLMMTFVQLGGALVTKTGSADGCGSSWPLCHGALIPEFFPIDTIIELSHRAVSALSLLMVLWLVITAWKHIGYIKEIKPLSIISVGFLLLQALIGAAAVIWQQNDYVLALHFGISLISFSSVFLITLIIFSIDQKYEADELYIKKPLRRLTWLMAIIIYCGVYTGALVRHADASLAYGGWPLPFHDLVPHSEQDWVQLTHRIMAFIVFTIIMITYIHAVKNYPNNRTVHYGYTAAFILVILQVITGALSIMTNVNLIIALFHALFITYLFGMTTYFIMLMLRSVRSDKQ

Experimental data[edit source | edit]

  • experimental localization: Integral membrane [1]

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

  • ctaA no polycistronic organisation predicted

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

  1. Dörte Becher, Kristina Hempel, Susanne Sievers, Daniela Zühlke, Jan Pané-Farré, Andreas Otto, Stephan Fuchs, Dirk Albrecht, Jörg Bernhardt, Susanne Engelmann, Uwe Völker, Jan Maarten van Dijl, Michael Hecker
    A proteomic view of an important human pathogen--towards the quantification of the entire Staphylococcus aureus proteome.
    PLoS ONE: 2009, 4(12);e8176
    [PubMed:19997597] [WorldCat.org] [DOI] (I e)

Relevant publications[edit source | edit]