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NCBI: 02-MAR-2017

Summary[edit source | edit]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL_RS09035 [old locus tag: SACOL1767 ]
  • pan locus tag?: SAUPAN004370000
  • symbol: SACOL_RS09035
  • pan gene symbol?: ezrA
  • synonym:
  • product: septation ring formation regulator EzrA

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: SACOL_RS09035 [old locus tag: SACOL1767 ]
  • symbol: SACOL_RS09035
  • product: septation ring formation regulator EzrA
  • replicon: chromosome
  • strand: -
  • coordinates: 1805997..1807691
  • length: 1695
  • essential: unknown

Accession numbers[edit source | edit]

  • Location: NC_002951 (1805997..1807691) NCBI
  • MicrobesOnline:

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
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    361
    421
    481
    541
    601
    661
    721
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    841
    901
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    1021
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    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    ATGGTGTTATATATCATTTTGGCAATAATTGTGATTATATTGATTGCTGTAGGTGTATTA
    TTCTATTTACGTTCAAATAAACGACAAATTATTGAAAAAGCAATCGAACGTAAAAATGAA
    ATTGAGACGTTACCTTTTGATCAAAACCTTGCACAATTATCTAAGTTGAATTTAAAAGGT
    GAAACAAAAACGAAATACGATGCAATGAAAAAGGACAACGTAGAAAGTACAAATAAGTAT
    CTAGCTCCTGTGGAAGAAAAAATCCATAATGCTGAGGCTTTATTAGATAAATTTAGTTTC
    AACGCATCTCAAAGTGAAATTGATGATGCAAATGAGTTGATGGATAGTTACGAACAAAGC
    TATCAGCAACAATTAGAAGATGTAAATGAAATTATTGCGTTATACAAAGATAATGATGAA
    TTATATGACAAATGTAAGGTTGATTATCGTGAAATGAAACGTGATGTTTTAGCAAATCGT
    CATCAATTTGGTGAGGCAGCAAGTCTACTTGAAACTGAAATTGAAAAATTTGAGCCAAGG
    TTAGAGCAATATGAAGTACTAAAAGCTGATGGTAATTATGTACAAGCGCACAACCATATA
    GCTGCCTTGAATGAACAAATGAAACAGCTAAGATCTTATATGGAAGAAATACCAGAATTA
    ATTAGAGAAACTCAAAAAGAATTACCTGGTCAATTCCAAGATTTAAAATATGGTTGCCGT
    GATCTTAAAGTTGAAGGGTATGATCTGGATCACGTGAAAGTAGACAGTACATTACAAAGC
    TTAAAAACAGAGCTTAGTTTCGTTGAACCATTAATTAGCCGCTTAGAATTAGAAGAAGCT
    AATGATAAACTAGCTAATATCAATGATAAGTTAGATGACATGTATGATTTAATTGAACAT
    GAAGTTAAAGCTAAAAATGATGTCGAAGAAACAAAAGATATCATTACGGATAACTTATTC
    AAAGCTAAAGACATGAATTATACATTGCAAACAGAAATTGAATATGTACGTGAAAACTAC
    TATATAAATGAATCTGATGCTCAGAGTGTTCGTCAATTTGAAAATGAAATTCAAAGTTTA
    ATTTCTGTATATGATGATATTTTAAAAGAAATGTCTAAATCTGCTGTGCGATATAGCGAG
    GTTCAGGATAATTTACAATATTTAGAAGATCATGTCACAGTTATTAATGACAAACAAGAA
    AAGCTACAAAATCATCTGATTCAATTGCGTGAAGATGAAGCAGAAGCAGAAGACAATCTG
    CTACGAGTACAATCGAAGAAAGAAGAAGTGTATCGTCGATTACTTGCTTCTAACTTAACA
    AGCGTTCCTGAAAGGTTTATCATCATGAAAAATGAAATTGATCATGAAGTTCGTGATGTT
    AACGAACAATTTAGTGAACGTCCAATACACGTTAAACAGTTAAAAGATAAAGTGTCTAAA
    ATTGTGATTCAAATGAATACATTTGAAGATGAAGCAAATGATGTTCTTGTTAATGCTGTT
    TATGCAGAGAAATTAATTCAATATGGAAATAGATATCGTAAGGACTATAGCAATGTTGAT
    AAGAGCTTAAATGAAGCTGAACGATTATTTAAAAATAATCGCTATAAGCGTGCGATTGAA
    ATTGCAGAGCAAGCTCTTGAAAGTGTTGAGCCAGGTGTTACTAAACATATTGAAGAAGAA
    GTTATTAAGCAATAG
    60
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    360
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    480
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    840
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    1140
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    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1695

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: SACOL_RS09035 [old locus tag: SACOL1767 ]
  • symbol: SACOL_RS09035
  • description: septation ring formation regulator EzrA
  • length: 564
  • theoretical pI: 4.50272
  • theoretical MW: 66199
  • GRAVY: -0.686348

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
    Cellular processesCellular processesCell divisionchromosome segregation protein SMC (TIGR02168; HMM-score: 22.7)
    Genetic information processingDNA metabolismChromosome-associated proteinschromosome segregation protein SMC (TIGR02168; HMM-score: 22.7)
    Cellular processesCellular processesCell divisionchromosome segregation protein SMC (TIGR02169; HMM-score: 22.7)
    Genetic information processingDNA metabolismChromosome-associated proteinschromosome segregation protein SMC (TIGR02169; HMM-score: 22.7)
    Genetic information processingProtein fateProtein folding and stabilizationcytochrome c-type biogenesis protein CcmI (TIGR03142; HMM-score: 5.9)
    MetabolismEnergy metabolismElectron transportcytochrome c-type biogenesis protein CcmI (TIGR03142; HMM-score: 5.9)
  • TheSEED:
  • PFAM:
    no clan definedEzrA; Septation ring formation regulator, EzrA (PF06160; HMM-score: 529.1)
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain (PF16454; HMM-score: 22.7)
    GPW_gp25; Gene 25-like lysozyme (PF04965; HMM-score: 18.1)
    Ac110_PIF; Per os infectivity factor AC110 (PF07280; HMM-score: 15.6)
    TPR (CL0020) TPR_2; Tetratricopeptide repeat (PF07719; HMM-score: 12.5)
    no clan definedASFV_J13L; African swine fever virus J13L protein (PF05568; HMM-score: 12.4)
    DUF2106; Predicted membrane protein (DUF2106) (PF09879; HMM-score: 12)
    TPR (CL0020) ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3 (PF12895; HMM-score: 12)
    TPR_16; Tetratricopeptide repeat (PF13432; HMM-score: 11.1)
    no clan definedMed9; RNA polymerase II transcription mediator complex subunit 9 (PF07544; HMM-score: 10.8)
    IncA; IncA protein (PF04156; HMM-score: 9.3)
    SIT; SHP2-interacting transmembrane adaptor protein, SIT (PF15330; HMM-score: 9.2)
    HTH (CL0123) MerR-DNA-bind; MerR, DNA binding (PF09278; HMM-score: 7.7)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 10
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helix: 1
  • LocateP:
  • SignalP: no predicted signal peptide
    • Ymax: 0.158
    • Ymax_pos: 35
    • Cmax: 0.145
    • Cmax_pos: 35
    • Smax: 0.258
    • Smax_pos: 2
    • Smean: 0.137
    • D: 0.15
  • predicted transmembrane helices (TMHMM): 1

Accession numbers[edit source | edit]

  • GI: 446167010 NCBI
  • RefSeq: WP_000244865 NCBI
  • UniProt:

Protein sequence[edit source | edit]

  • MVLYIILAIIVIILIAVGVLFYLRSNKRQIIEKAIERKNEIETLPFDQNLAQLSKLNLKGETKTKYDAMKKDNVESTNKYLAPVEEKIHNAEALLDKFSFNASQSEIDDANELMDSYEQSYQQQLEDVNEIIALYKDNDELYDKCKVDYREMKRDVLANRHQFGEAASLLETEIEKFEPRLEQYEVLKADGNYVQAHNHIAALNEQMKQLRSYMEEIPELIRETQKELPGQFQDLKYGCRDLKVEGYDLDHVKVDSTLQSLKTELSFVEPLISRLELEEANDKLANINDKLDDMYDLIEHEVKAKNDVEETKDIITDNLFKAKDMNYTLQTEIEYVRENYYINESDAQSVRQFENEIQSLISVYDDILKEMSKSAVRYSEVQDNLQYLEDHVTVINDKQEKLQNHLIQLREDEAEAEDNLLRVQSKKEEVYRRLLASNLTSVPERFIIMKNEIDHEVRDVNEQFSERPIHVKQLKDKVSKIVIQMNTFEDEANDVLVNAVYAEKLIQYGNRYRKDYSNVDKSLNEAERLFKNNRYKRAIEIAEQALESVEPGVTKHIEEEVIKQ

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

  • SACOL_RS09035 no polycistronic organisation predicted

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]