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NCBI: 02-MAR-2017

Summary[edit source | edit]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL_RS12760 [old locus tag: SACOL2431 ]
  • pan locus tag?: SAUPAN005972000
  • symbol: SACOL_RS12760
  • pan gene symbol?:
  • synonym:
  • product: ABC transporter ATP-binding protein

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: SACOL_RS12760 [old locus tag: SACOL2431 ]
  • symbol: SACOL_RS12760
  • product: ABC transporter ATP-binding protein
  • replicon: chromosome
  • strand: -
  • coordinates: 2489554..2491317
  • length: 1764
  • essential: unknown

Accession numbers[edit source | edit]

  • Location: NC_002951 (2489554..2491317) NCBI
  • MicrobesOnline:

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    ATGAACAATCAGACAAATTGGATAAAGATACTCAGCGGATTTGCTTCTGATAGTAAATGG
    AAAATTATGTTATCAATTTTGTTGTCTATCATCAGTGTCTTTTCTGGATTAGTTCCTTAT
    TGGGCAGTATTTAAAATTATTTTAATGATGATTAACAATACATATACGATTAATTCGATT
    ATGGTTTATATCTTTATTGCTTTAATCGCTTATATTTCACAAGTGTGTTGTTTTGGAGCG
    TCAACGATGCTATCACATATTACGGCATATGAAATTTTATCTGAAATTCGTAAAAAATTA
    GCTCAAAAATTAATGCGTCTCCCTTTAGGCGTAGTGGAATCTAAGAAAATAGGTGAATTA
    AAAAATATATTTGTCGATAAGGTTGAAACAATAGAATTACCTTTAGCACATATGATTCCT
    GAAGTTATAGGAAACTTACTTTTGTCAGCTGCTATCTTTTTATACATAATGCTCATTGAT
    TGGCGTATGGCTAGTGCCTTATTAGTAACGATACCAATTTCAATTTTCGCTTTTAAAAAA
    GTTATGTCTGGATTTAATGAGACATATGCTGAACAAATGAAATCGAATAATTATATGAAT
    AGCGCGATTGTAGAGTTTATCGAAGGCATTGAAGTGATTAAAACATTTAATCAATCTCAA
    AGTTCATATAAAAAATATAAAGATGCAGTAGATAATTATAAGATTCACACTTTGAATTGG
    TTTAAAAATACATGGGGGTATATGAATTTAGGAGCTAGTGTATTACCTTCAACATTTTTA
    GGGATTTTACCGGTCGGCATGTATTTGATATCTATCAACCAATTAAACTATGCGGAATTT
    TTCCTATGCATCGTATTATCTTTAGGTGTAGTAGCACCGATTAAGAATTTTACTAATTAT
    GTAAATCATTTAAAGTCTATACAATACGCATTAACTGAAGTGAATCAAATATTAAGTCTA
    GAAGAGTTAGTATTGTCAACAAAATTTAAGAAGCCTCAACATTATGAAATTGCTTTTAAT
    AATGTTGGATTTTCATATAACAAAGATAAGGACGATCTGGTCTTTAAGCATTTATCATTT
    ACAGTACCAGAAAATAATTTCACAGCTATCGTCGGGGCATCTGGTAGCGGTAAGTCAACC
    ATTGCCAAGCTTATATCACGATACTGGGATGTGACTTCAGGTGAAATTACGATTGGCGGT
    ATAAATATAAAAGATATTGAATCGAAACAACTTAACGATTTAGTTGGTTTTGTTGGACAA
    GATAACTTTTTATTAAATCTTACTTTTAAAGAAAATATTAAACTTGGCAATCCAGAAGCT
    ACGGATGAGGCAGTTGAAAAAGCTGCCAAGTTAGCACAATGTCATGAATTTATTGAAAAG
    TTGCCAGATGGATATGATACGAATGTTGGTACAGTGGGAGATAAATTGTCTGGTGGTGAA
    AAACAACGAGTCACTATTGCAAGAATGATATTAAAAGATGCGCCTATCATTGTATTAGAT
    GAAGCGACTGTTTACGTTGATCCAGACAACGAACAAAAAATTCAAGAAGCATTAAATGTG
    TTGACGCAGGATAAAACATTGATTGTTATTGCACATCGGTTATCTACGATTCAACATGCA
    GATCAAATTATTGTTTTAGGTAAACAACAAATTTTAGAAAAAGGGTCACATCACTTATTG
    CTAAAATTAAACGGTAATTATAAGAAAATGTGGGATACGCACATGCATACAAAAGATTGG
    GGAATCAATACTGGACATAATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1764

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: SACOL_RS12760 [old locus tag: SACOL2431 ]
  • symbol: SACOL_RS12760
  • description: ABC transporter ATP-binding protein
  • length: 587
  • theoretical pI: 7.71696
  • theoretical MW: 66115.6
  • GRAVY: 0.133731

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
    Cell structureCell envelopeBiosynthesis and degradation of surface polysaccharides and lipopolysaccharideslipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 340.2)
    MetabolismTransport and binding proteinsOtherlipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 340.2)
    ABC transporter, permease/ATP-binding protein (TIGR02204; HMM-score: 308.8)
    thiol reductant ABC exporter, CydD subunit (TIGR02857; HMM-score: 291.9)
    MetabolismTransport and binding proteinsOtherantigen peptide transporter 2 (TIGR00958; HMM-score: 279.7)
    Genetic information processingProtein fateProtein and peptide secretion and traffickingtype I secretion system ATPase (TIGR01846; HMM-score: 271.3)
    Genetic information processingProtein fateProtein and peptide secretion and traffickingABC-type bacteriocin transporter (TIGR01193; HMM-score: 270.6)
    Genetic information processingProtein fateProtein modification and repairABC-type bacteriocin transporter (TIGR01193; HMM-score: 270.6)
    MetabolismTransport and binding proteinsOtherABC-type bacteriocin transporter (TIGR01193; HMM-score: 270.6)
    Cellular processesCellular processesPathogenesistype I secretion system ATPase (TIGR03375; HMM-score: 266.4)
    Genetic information processingProtein fateProtein and peptide secretion and traffickingtype I secretion system ATPase (TIGR03375; HMM-score: 266.4)
    Cellular processesCellular processesBiosynthesis of natural productsNHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 239.2)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesNHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 239.2)
    MetabolismTransport and binding proteinsCarbohydrates, organic alcohols, and acidsglucan exporter ATP-binding protein (TIGR01192; EC 3.6.3.42; HMM-score: 232)
    thiol reductant ABC exporter, CydC subunit (TIGR02868; HMM-score: 217.3)
    Cellular processesCellular processesBiosynthesis of natural productsNHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 210.7)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesNHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 210.7)
    Genetic information processingProtein fateProtein and peptide secretion and traffickingtype I secretion system ATPase (TIGR01842; HMM-score: 185.9)
    MetabolismTransport and binding proteinsOthermulti drug resistance-associated protein (MRP) (TIGR00957; HMM-score: 148.7)
    MetabolismTransport and binding proteinsUnknown substrateenergy-coupling factor transporter ATPase (TIGR04520; EC 3.6.3.-; HMM-score: 131.2)
    Cellular processesCellular processesToxin production and resistanceputative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 111.3)
    MetabolismTransport and binding proteinsUnknown substrateputative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 111.3)
    MetabolismTransport and binding proteinsUnknown substrateenergy-coupling factor transporter ATPase (TIGR04521; EC 3.6.3.-; HMM-score: 109.4)
    Cellular processesCellular processesCell divisioncell division ATP-binding protein FtsE (TIGR02673; HMM-score: 100.9)
    MetabolismTransport and binding proteinsCarbohydrates, organic alcohols, and acidsABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system (TIGR03864; HMM-score: 96.7)
    MetabolismTransport and binding proteinsAnionsphosphate ABC transporter, ATP-binding protein (TIGR00972; EC 3.6.3.27; HMM-score: 95.8)
    MetabolismTransport and binding proteinsAnionscystic fibrosis transmembrane conductor regulator (CFTR) (TIGR01271; EC 3.6.3.49; HMM-score: 94.4)
    Genetic information processingProtein fateProtein and peptide secretion and traffickinglipoprotein releasing system, ATP-binding protein (TIGR02211; EC 3.6.3.-; HMM-score: 91.3)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesglycine betaine/L-proline transport ATP binding subunit (TIGR01186; HMM-score: 90.7)
    MetabolismTransport and binding proteinsAnionsphosphonate ABC transporter, ATP-binding protein (TIGR02315; EC 3.6.3.28; HMM-score: 88.9)
    MetabolismTransport and binding proteinsOtherthiamine ABC transporter, ATP-binding protein (TIGR01277; EC 3.6.3.-; HMM-score: 84.6)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesurea ABC transporter, ATP-binding protein UrtE (TIGR03410; HMM-score: 84.6)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminescyclic peptide transporter (TIGR01194; HMM-score: 81)
    MetabolismTransport and binding proteinsOthercyclic peptide transporter (TIGR01194; HMM-score: 81)
    ABC exporter ATP-binding subunit, DevA family (TIGR02982; HMM-score: 80.7)
    gliding motility-associated ABC transporter ATP-binding subunit GldA (TIGR03522; HMM-score: 73.5)
    MetabolismTransport and binding proteinsCations and iron carrying compoundsnickel import ATP-binding protein NikE (TIGR02769; EC 3.6.3.24; HMM-score: 73.1)
    MetabolismTransport and binding proteinsAnionsmolybdate ABC transporter, ATP-binding protein (TIGR02142; EC 3.6.3.29; HMM-score: 72.6)
    MetabolismTransport and binding proteinsAnionssulfate ABC transporter, ATP-binding protein (TIGR00968; EC 3.6.3.25; HMM-score: 72.2)
    proposed F420-0 ABC transporter, ATP-binding protein (TIGR03873; HMM-score: 72.1)
    MetabolismTransport and binding proteinsOtherpigment precursor permease (TIGR00955; HMM-score: 70.3)
    ATP-binding cassette protein, ChvD family (TIGR03719; HMM-score: 68.5)
    MetabolismTransport and binding proteinsCations and iron carrying compoundsnickel import ATP-binding protein NikD (TIGR02770; HMM-score: 67.8)
    MetabolismTransport and binding proteinsOtherdaunorubicin resistance ABC transporter, ATP-binding protein (TIGR01188; HMM-score: 67.7)
    lantibiotic protection ABC transporter, ATP-binding subunit (TIGR03740; HMM-score: 67.6)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesputative 2-aminoethylphosphonate ABC transporter, ATP-binding protein (TIGR03265; HMM-score: 67)
    Cell structureCell envelopeBiosynthesis and degradation of surface polysaccharides and lipopolysaccharidesLPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 64.4)
    MetabolismTransport and binding proteinsOtherLPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 64.4)
    phosphonate C-P lyase system protein PhnL (TIGR02324; HMM-score: 63.8)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesurea ABC transporter, ATP-binding protein UrtD (TIGR03411; HMM-score: 63.7)
    D-methionine ABC transporter, ATP-binding protein (TIGR02314; EC 3.6.3.-; HMM-score: 63.3)
    MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersOtherFeS assembly ATPase SufC (TIGR01978; HMM-score: 62.8)
    Cellular processesCellular processesOthernodulation ABC transporter NodI (TIGR01288; HMM-score: 62)
    MetabolismTransport and binding proteinsOthernodulation ABC transporter NodI (TIGR01288; HMM-score: 62)
    Genetic information processingProtein fateProtein and peptide secretion and traffickingheme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 61.7)
    MetabolismTransport and binding proteinsOtherheme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 61.7)
    MetabolismTransport and binding proteinsCarbohydrates, organic alcohols, and acidsperoxysomal long chain fatty acyl transporter (TIGR00954; HMM-score: 61.4)
    MetabolismTransport and binding proteinsCations and iron carrying compoundscobalt ABC transporter, ATP-binding protein (TIGR01166; HMM-score: 61.4)
    MetabolismTransport and binding proteinsAnionsnitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 56)
    MetabolismTransport and binding proteinsOthernitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 56)
    2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT (TIGR03258; HMM-score: 54.1)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminespolyamine ABC transporter, ATP-binding protein (TIGR01187; EC 3.6.3.31; HMM-score: 53.7)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminescholine ABC transporter, ATP-binding protein (TIGR03415; HMM-score: 53.7)
    MetabolismEnergy metabolismMethanogenesismethyl coenzyme M reductase system, component A2 (TIGR03269; HMM-score: 53.3)
    ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA (TIGR03005; HMM-score: 52.9)
    MetabolismTransport and binding proteinsOtherrim ABC transporter (TIGR01257; HMM-score: 43.4)
    MetabolismTransport and binding proteinsCarbohydrates, organic alcohols, and acidsD-xylose ABC transporter, ATP-binding protein (TIGR02633; EC 3.6.3.17; HMM-score: 42.2)
    Genetic information processingDNA metabolismDNA replication, recombination, and repairexcinuclease ABC subunit A (TIGR00630; EC 3.1.25.-; HMM-score: 41.7)
    MetabolismTransport and binding proteinsOtherpleiotropic drug resistance family protein (TIGR00956; HMM-score: 40.5)
    MetabolismTransport and binding proteinsUnknown substrateanchored repeat-type ABC transporter, ATP-binding subunit (TIGR03771; HMM-score: 39.8)
    MetabolismCentral intermediary metabolismPhosphorus compoundsphosphonate C-P lyase system protein PhnK (TIGR02323; HMM-score: 29.4)
    Cellular processesCellular processesCell divisionchromosome segregation protein SMC (TIGR02168; HMM-score: 27.7)
    Genetic information processingDNA metabolismChromosome-associated proteinschromosome segregation protein SMC (TIGR02168; HMM-score: 27.7)
    Cellular processesCellular processesCell divisionchromosome segregation protein SMC (TIGR02169; HMM-score: 24.8)
    Genetic information processingDNA metabolismChromosome-associated proteinschromosome segregation protein SMC (TIGR02169; HMM-score: 24.8)
    Genetic information processingDNA metabolismDNA replication, recombination, and repairDNA repair protein RecN (TIGR00634; HMM-score: 13.3)
    Genetic information processingTranscriptionRNA processingpolynucleotide kinase-phosphatase (TIGR04075; HMM-score: 10.9)
  • TheSEED:
  • PFAM:
    P-loop_NTPase (CL0023) ABC_tran; ABC transporter (PF00005; HMM-score: 104.7)
    ABC_membrane (CL0241) ABC_membrane; ABC transporter transmembrane region (PF00664; HMM-score: 90.1)
    P-loop_NTPase (CL0023) SMC_N; RecF/RecN/SMC N terminal domain (PF02463; HMM-score: 39.4)
    AAA_23; AAA domain (PF13476; HMM-score: 21.4)
    AAA_21; AAA domain, putative AbiEii toxin, Type IV TA system (PF13304; HMM-score: 20.5)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 20)
    AAA_15; AAA ATPase domain (PF13175; HMM-score: 17.8)
    ABC_ATPase; Predicted ATPase of the ABC class (PF09818; HMM-score: 16.3)
    RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 16)
    DUF87; Domain of unknown function DUF87 (PF01935; HMM-score: 15.8)
    AAA_18; AAA domain (PF13238; HMM-score: 15.4)
    AAA_30; AAA domain (PF13604; HMM-score: 15.2)
    NB-ARC; NB-ARC domain (PF00931; HMM-score: 15.1)
    AAA_10; AAA-like domain (PF12846; HMM-score: 14.4)
    AAA_22; AAA domain (PF13401; HMM-score: 13.8)
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 13.3)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 13)
    SbcCD_C; Putative exonuclease SbcCD, C subunit (PF13558; HMM-score: 12)
    NADP_Rossmann (CL0063) Methyltransf_31; Methyltransferase domain (PF13847; HMM-score: 11.6)
    no clan definedDUF3987; Protein of unknown function (DUF3987) (PF13148; HMM-score: 11.4)
    P-loop_NTPase (CL0023) MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 9.6)
    no clan definedDUF4229; Protein of unknown function (DUF4229) (PF14012; HMM-score: 8.4)
    COX2-transmemb; Cytochrome C oxidase subunit II, transmembrane (PF09125; HMM-score: 7.4)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:
    SACOL_RS08865aldehyde dehydrogenase  [1] (data from MRSA252)

Localization[edit source | edit]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 4
  • LocateP:
  • SignalP: no predicted signal peptide
    • Ymax: 0.132
    • Ymax_pos: 43
    • Cmax: 0.214
    • Cmax_pos: 43
    • Smax: 0.201
    • Smax_pos: 26
    • Smean: 0.121
    • D: 0.128
  • predicted transmembrane helices (TMHMM): 5

Accession numbers[edit source | edit]

  • GI: 446987582 NCBI
  • RefSeq: WP_001064838 NCBI
  • UniProt:

Protein sequence[edit source | edit]

  • MNNQTNWIKILSGFASDSKWKIMLSILLSIISVFSGLVPYWAVFKIILMMINNTYTINSIMVYIFIALIAYISQVCCFGASTMLSHITAYEILSEIRKKLAQKLMRLPLGVVESKKIGELKNIFVDKVETIELPLAHMIPEVIGNLLLSAAIFLYIMLIDWRMASALLVTIPISIFAFKKVMSGFNETYAEQMKSNNYMNSAIVEFIEGIEVIKTFNQSQSSYKKYKDAVDNYKIHTLNWFKNTWGYMNLGASVLPSTFLGILPVGMYLISINQLNYAEFFLCIVLSLGVVAPIKNFTNYVNHLKSIQYALTEVNQILSLEELVLSTKFKKPQHYEIAFNNVGFSYNKDKDDLVFKHLSFTVPENNFTAIVGASGSGKSTIAKLISRYWDVTSGEITIGGINIKDIESKQLNDLVGFVGQDNFLLNLTFKENIKLGNPEATDEAVEKAAKLAQCHEFIEKLPDGYDTNVGTVGDKLSGGEKQRVTIARMILKDAPIIVLDEATVYVDPDNEQKIQEALNVLTQDKTLIVIAHRLSTIQHADQIIVLGKQQILEKGSHHLLLKLNGNYKKMWDTHMHTKDWGINTGHN

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

  • SACOL_RS12760 no polycistronic organisation predicted

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

  1. Artem Cherkasov, Michael Hsing, Roya Zoraghi, Leonard J Foster, Raymond H See, Nikolay Stoynov, Jihong Jiang, Sukhbir Kaur, Tian Lian, Linda Jackson, Huansheng Gong, Rick Swayze, Emily Amandoron, Farhad Hormozdiari, Phuong Dao, Cenk Sahinalp, Osvaldo Santos-Filho, Peter Axerio-Cilies, Kendall Byler, William R McMaster, Robert C Brunham, B Brett Finlay, Neil E Reiner
    Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus.
    J. Proteome Res.: 2011, 10(3);1139-50
    [PubMed:21166474] [WorldCat.org] [DOI] (I p)

Relevant publications[edit source | edit]