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NCBI: 02-MAR-2017

Summary[edit source | edit]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL_RS12815 [old locus tag: SACOL2442 ]
  • pan locus tag?: SAUPAN005988000
  • symbol: SACOL_RS12815
  • pan gene symbol?:
  • synonym:
  • product: sodium:proton antiporter

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: SACOL_RS12815 [old locus tag: SACOL2442 ]
  • symbol: SACOL_RS12815
  • product: sodium:proton antiporter
  • replicon: chromosome
  • strand: +
  • coordinates: 2500162..2502240
  • length: 2079
  • essential: unknown

Accession numbers[edit source | edit]

  • Location: NC_002951 (2500162..2502240) NCBI
  • MicrobesOnline:

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
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    361
    421
    481
    541
    601
    661
    721
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    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
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    1621
    1681
    1741
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    1921
    1981
    2041
    ATGGCACTATTAGAAGTATTTTTAATTTTTATTTTTGCTGTGATTATTAGTTCGGTTATC
    AATAATCGATTCCCACAAATTCCTACTGCCTTTATTCAAATTGCATTAGGTGTCGTTATT
    TTCATTATTCCAATACAAGTTGATTTCCAATTCAATTCTGAAGTATTTATGTTTGCCGTT
    ATCGCGCCACTACTTTTTGTGGAAGGTACCCACGTCTCTCGAACAAAATTATTAGAATAT
    CGTAAACCTATACTATTAATGTCAATGGCACTAGTGTTTGCAACTGTAGTCGGTGTTGGC
    TATTTTATACATTGGATTTGGCCTGCCTTACCAATGCCAGCCGCTTTTGCAATAGCAGCA
    ATTTTATGTCCTACTGATGCAGTAGCAGTATCTGCTATTACACGCGGAAAATTATTACCT
    AAAGGTTCTATGACGATTTTAGAAGGTGAATCTTTACTCAATGATGCAGCAGGTATCATT
    TCATTTAAAATTGCTGTTACTGCATTAGTAACTGGTACCTTTTCATTATTCCAAGCTGTT
    GAACAATTTATCATTTCAACAATACTAGGTGTACTTATTGGTGCAATTATTGGATTCGTT
    GTCGTTAGAATACGTATAGACTTAACCGCTAATAAAGGTTTAAAAGATAACAATACCTTA
    ACTTTTATTCAATTATTAACTCCTTTTGTCGTATACTTTTTAGCAGAAGAAGTTCATGCT
    TCAGGTATCATTGCAGTTGTAATCGCAGGTCTAATCCATGGTTTAGAACGCGACCGTTTA
    ATTAGAGCACAAACGGAACTACAAATGAATTACCATCAAATTTGGAACACATTTAGTTAT
    GCCTTAAATGGTTTTGTATTTGTTGTATTAGGTTTTATGATTCCTACTGTAGTCATAGAT
    ATTTTCCAAACAGAGCCTGACAACTTTTCATTTTTAATAGTGATCACTATATTAATCGCT
    ATTGCAATTTATGCATGTCGATTTGTTTGGGTTTATTTCTGGTACAAAGATTTTTATTTC
    CCGAAAAATATACAATCTTATCTAGACGAGGAACATGATTCACATGAAACACCACCTTCT
    CGAGTGCGTTACGCATTTATTATGACCATGTGTGGTATTCACGGTACAATTTCACTTTCA
    ATGGCACTTACATTACCATTTATCATTACAAAAGGACAAGCATTCGAATACCGTAATGAT
    TTATTGTTTATTGCATCTTTCATGGTATTAATTAGTTTAATCTTAGCGCAAATTGTTTTA
    CCTTTAATTACACCATCTGCCGAAGATACTACTTTTAAAGGTATGACTTATCAATCTGCC
    AAAATTTTCATTGTTCAAAAAGTGATCCAGCATTTTAAAAACGAAAGTAAAAAAGACAAA
    AACGATACAAATTATCGCCCAGTATTAAACCAATACTATGGAGAATTGTTATTTTTATTA
    AATTCAGAACCTGATAATCAAAATACAAAAGAACTCAAACGTTTAGAAGATATTGCAAAA
    GTAATCGAAACATCTACACTTGAGCGTTTAATTGATAAAGGTAAGGCAACATATCAGGAT
    ATTAATAATTACCGCAATATTGTCGAATTAACAGAGACACACCGTACTGCATCATTTGTT
    GAAAAATTTGCAAACTTCTTCAAGATGTTATGGCTTAGACTTAAAGCGATGAAGCACTAC
    AAAGCCTTAAATAAAGAATCTAAGAAGCAAGAATTTGAAAATTCATTCAAAGATGTTCAA
    AAAATTATGCGTATTGTGAATCACAATATTATTTTACGCTTAAAAGAAGAACAAAATAGT
    ACAAATGTACTTGAGGTTAGCTTAGTCATTAATCATTACTATGATATGAGTCGCTCATTA
    AAGTGGCGTGCACAACGTCGAAAAGAACGTCAAGAAAACAGCAATCAAATCATACCGCAA
    GCTATGTTCCATAACCACAAATTGGAAGCATTGTACTTACAACGTCATCTTTTAGATGAA
    TTAATTCGCAAAAATAAAATCAACAATATCGTTGCAGCTCAAATTCGAGAAAATATCAAT
    TACAACGAAATTGTCTTGTCTTTACAGTCCAAACATTAA
    60
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    2079

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: SACOL_RS12815 [old locus tag: SACOL2442 ]
  • symbol: SACOL_RS12815
  • description: sodium:proton antiporter
  • length: 692
  • theoretical pI: 9.22136
  • theoretical MW: 79367.6
  • GRAVY: 0.280202

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
    MetabolismTransport and binding proteinsCations and iron carrying compoundsNa+/H+ antiporter (TIGR00831; HMM-score: 250.6)
    MetabolismTransport and binding proteinsCations and iron carrying compoundssodium/hydrogen exchanger 3 (TIGR00840; HMM-score: 56.5)
  • TheSEED:
  • PFAM:
    CPA_AT (CL0064) Na_H_Exchanger; Sodium/hydrogen exchanger family (PF00999; HMM-score: 173.8)
    no clan definedDUF2157; Predicted membrane protein (DUF2157) (PF09925; HMM-score: 16.2)
    DUF3139; Protein of unknown function (DUF3139) (PF11337; HMM-score: 12.9)
    Phage_holin_3_6; Putative Actinobacterial Holin-X, holin superfamily III (PF07332; HMM-score: 10.3)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 10
  • LocateP:
  • SignalP: no predicted signal peptide
    • Ymax: 0.153
    • Ymax_pos: 26
    • Cmax: 0.149
    • Cmax_pos: 26
    • Smax: 0.223
    • Smax_pos: 7
    • Smean: 0.166
    • D: 0.158
  • predicted transmembrane helices (TMHMM): 12

Accession numbers[edit source | edit]

  • GI: 447108721 NCBI
  • RefSeq: WP_001185977 NCBI
  • UniProt:

Protein sequence[edit source | edit]

  • MALLEVFLIFIFAVIISSVINNRFPQIPTAFIQIALGVVIFIIPIQVDFQFNSEVFMFAVIAPLLFVEGTHVSRTKLLEYRKPILLMSMALVFATVVGVGYFIHWIWPALPMPAAFAIAAILCPTDAVAVSAITRGKLLPKGSMTILEGESLLNDAAGIISFKIAVTALVTGTFSLFQAVEQFIISTILGVLIGAIIGFVVVRIRIDLTANKGLKDNNTLTFIQLLTPFVVYFLAEEVHASGIIAVVIAGLIHGLERDRLIRAQTELQMNYHQIWNTFSYALNGFVFVVLGFMIPTVVIDIFQTEPDNFSFLIVITILIAIAIYACRFVWVYFWYKDFYFPKNIQSYLDEEHDSHETPPSRVRYAFIMTMCGIHGTISLSMALTLPFIITKGQAFEYRNDLLFIASFMVLISLILAQIVLPLITPSAEDTTFKGMTYQSAKIFIVQKVIQHFKNESKKDKNDTNYRPVLNQYYGELLFLLNSEPDNQNTKELKRLEDIAKVIETSTLERLIDKGKATYQDINNYRNIVELTETHRTASFVEKFANFFKMLWLRLKAMKHYKALNKESKKQEFENSFKDVQKIMRIVNHNIILRLKEEQNSTNVLEVSLVINHYYDMSRSLKWRAQRRKERQENSNQIIPQAMFHNHKLEALYLQRHLLDELIRKNKINNIVAAQIRENINYNEIVLSLQSKH

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

  • SACOL_RS12815 no polycistronic organisation predicted

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]