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NCBI: 02-MAR-2017

Summary[edit source | edit]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL_RS12895 [old locus tag: SACOL2458 ]
  • pan locus tag?: SAUPAN006006000
  • symbol: SACOL_RS12895
  • pan gene symbol?:
  • synonym:
  • product: amino acid:proton symporter

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: SACOL_RS12895 [old locus tag: SACOL2458 ]
  • symbol: SACOL_RS12895
  • product: amino acid:proton symporter
  • replicon: chromosome
  • strand: +
  • coordinates: 2515017..2516654
  • length: 1638
  • essential: unknown

Accession numbers[edit source | edit]

  • Location: NC_002951 (2515017..2516654) NCBI
  • MicrobesOnline:

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    ATGAATAAAGACAAGCAATTGCACAACGACAAAATCAATCTATCCCAATTAGTCTTATTA
    GGGTTAGGCTCTTTAATAGGATCTGGTTGGCTATTTGGTGCGTGGGAAGCATCATCAATA
    GCTGGACCAGCAGCAATCATATCATGGGTTCTTGGATTCCTAGTCATTGGAACCATTGCC
    TATAACTACATTGAAATCGGCACAATGTTTCCTCAATCAGGTGGCATGAGTAACTATGCC
    CAGTATACACATGGCTCATTATTAGGCTTTATTGCTGCTTGGGCGAATTGGGTGTCTTTG
    GTGACAATAATACCTATCGAAGCTGTGTCAGCTGTTCAATATATGAGTTCTTGGCCGTGG
    CATTGGGCGAAACCAATGAGATATTTAATGGAAAATGGCTCTATTAGCACATACGGATTG
    CTAGCTGTATATCTCATCATTGTTATTTTTTCATTATTAAACTATTGGTCCGTAAAACTT
    TTAACATCATTTACGAGTTTAATTTCTGTATTTAAATTAGGCGTACCCATGTTAACCATC
    ATCATGTTGATGCTATCAGGATTCGACACTTCAAATTACGGCCATTCGGCAAGCACATTT
    ATGCCTTACGGAAGTGCACCGATTTTTGCTGCAACAACAGCATCAGGGATTATTTTTTCA
    TTCAATTCATTCCAGACAATTATTAATATGGGTTCAGAAATTAAAAATCCTGAAAAAAAT
    ATCGCAAGAGGCATCGCTATCTCACTGTCAATCAGTGCAGTGTTGTACATCATTTTACAA
    AGTACGTTTATCACTTCTATGCCTCAATCAATGTTACAACATAGTGGATGGAATGGCATC
    AACTTCAATTCACCATTTGCTGATTTAGCTATCTTATTAGGAATTAATTGGCTCGCAATT
    TTACTATACATTGAAGCTTTTGTATCACCATTCGGTACTGGCGTGTCATTTGTCGCCGTT
    ACAGGTCGAGTTTTACGAGCAATGGAGAAAAATGGACATATCCCTAAATTTCTTGGGAAG
    ATGAATGAAAAATATCATATCCCACGTGTAGCAATCATCTTTAATGCCATCATTAGTATG
    ATTATGGTTACATTATTTAGAGATTGGGGTACGCTAGCAGCAGTTATTTCTACTGCAACT
    TTAGTAGCCTATTTAACTGGCCCAACGACAGTGATTGCATTAAGAAAAATGGGACCAACA
    ATGACTCGTCCATTTAGAGCAAAAATTTTAAAAGTAATGGCACCATTATCATTTGTATTA
    GCTTCATTAGCTATATATTGGGCAATGTGGCCAACAACGGCTGAAGTTATTTTAATCATT
    ATACTTGGATTACCAATCTACTTCTTCTATGAATATCGTATGAATTGGCGTAATACAAAG
    AAACAAATTGGTGGTAGCTTATGGATTATTGTATATTTAATCGTGCTATCAATACTGTCA
    TTTATAGGAAGCAAAGAATTTAAAGGCTTAAATATGATTCACTATCCATTTGACTTTATC
    GTTATTATTATTGTGGCACTTATCTTCTATTACATCGGTACAACGAGTTCATTTGAAAGC
    GTCTATTTCCGTCGCGCAACACGAATCAATACGAAGATGCGTGAGTCACTAAATAATGAA
    TCAAAGTCATCTCATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
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    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1638

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: SACOL_RS12895 [old locus tag: SACOL2458 ]
  • symbol: SACOL_RS12895
  • description: amino acid:proton symporter
  • length: 545
  • theoretical pI: 10.0252
  • theoretical MW: 60640.3
  • GRAVY: 0.604404

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesamino acid transporter (TIGR00909; HMM-score: 175.7)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminescationic amino acid transport permease (TIGR00906; HMM-score: 98.9)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesL-type amino acid transporter (TIGR00911; HMM-score: 93.6)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminestransporter, basic amino acid/polyamine antiporter (APA) family (TIGR00905; HMM-score: 91.6)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesethanolamine permease (TIGR00908; HMM-score: 70.5)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesamino acid permease (yeast) (TIGR00913; HMM-score: 56.9)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesGABA permease (TIGR01773; HMM-score: 50.3)
    histidine-histamine antiporter (TIGR04298; HMM-score: 46.8)
    putrescine-ornithine antiporter (TIGR04299; HMM-score: 33.1)
    putative glutamate/gamma-aminobutyrate antiporter (TIGR03813; HMM-score: 31.3)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesarginine-ornithine antiporter (TIGR03810; HMM-score: 30.2)
  • TheSEED:
  • PFAM:
    APC (CL0062) AA_permease_2; Amino acid permease (PF13520; HMM-score: 145.8)
    AA_permease; Amino acid permease (PF00324; HMM-score: 108.6)
    no clan definedAc76; Orf76 (Ac76) (PF05814; HMM-score: 20.6)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 14
  • LocateP:
  • SignalP: no predicted signal peptide
    • Ymax: 0.192
    • Ymax_pos: 37
    • Cmax: 0.156
    • Cmax_pos: 37
    • Smax: 0.314
    • Smax_pos: 33
    • Smean: 0.187
    • D: 0.19
  • predicted transmembrane helices (TMHMM): 14

Accession numbers[edit source | edit]

  • GI: 446953455 NCBI
  • RefSeq: WP_001030711 NCBI
  • UniProt:

Protein sequence[edit source | edit]

  • MNKDKQLHNDKINLSQLVLLGLGSLIGSGWLFGAWEASSIAGPAAIISWVLGFLVIGTIAYNYIEIGTMFPQSGGMSNYAQYTHGSLLGFIAAWANWVSLVTIIPIEAVSAVQYMSSWPWHWAKPMRYLMENGSISTYGLLAVYLIIVIFSLLNYWSVKLLTSFTSLISVFKLGVPMLTIIMLMLSGFDTSNYGHSASTFMPYGSAPIFAATTASGIIFSFNSFQTIINMGSEIKNPEKNIARGIAISLSISAVLYIILQSTFITSMPQSMLQHSGWNGINFNSPFADLAILLGINWLAILLYIEAFVSPFGTGVSFVAVTGRVLRAMEKNGHIPKFLGKMNEKYHIPRVAIIFNAIISMIMVTLFRDWGTLAAVISTATLVAYLTGPTTVIALRKMGPTMTRPFRAKILKVMAPLSFVLASLAIYWAMWPTTAEVILIIILGLPIYFFYEYRMNWRNTKKQIGGSLWIIVYLIVLSILSFIGSKEFKGLNMIHYPFDFIVIIIVALIFYYIGTTSSFESVYFRRATRINTKMRESLNNESKSSH

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

  • SACOL_RS12895 no polycistronic organisation predicted

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]