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NCBI: 10-JUN-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus USA300_FPR3757
  • locus tag: SAUSA300_1681 [new locus tag: SAUSA300_RS09180 ]
  • pan locus tag?: SAUPAN004399000
  • symbol: acuC
  • pan gene symbol?: acuC
  • synonym:
  • product: acetoin utilization protein AcuC

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: SAUSA300_1681 [new locus tag: SAUSA300_RS09180 ]
  • symbol: acuC
  • product: acetoin utilization protein AcuC
  • replicon: chromosome
  • strand: +
  • coordinates: 1851837..1853006
  • length: 1170
  • essential: unknown other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGCAACAACATTCATCAAAAACTGCATATGTTTATTCAGATAAGTTATTACAATATCGA
    TTTCATGACCAACATCCCTTCAATCAAATGCGTTTAAAATTAACAACAGAGCTACTTTTG
    AATGCAAATTTATTGTCTCCAGAACAAATAGTACAACCTAGAATTGCAACAGATGACGAA
    TTAATGTTAATTCATAAATATGATTACGTCGAAGCTATTAAGCATGCTTCACATGGCATT
    ATCAGTGAAGATGAGGCTAAGAAATATGGATTAAATGATGAAGAGAATGGTCAATTTAAG
    CATATGCACCGCCATAGTGCCACAATTGTTGGAGGCGCTTTAACTTTAGCAGATCTTATT
    ATGTCAGGCAAAGTATTAAATGGTTGTCACTTAGGTGGTGGTTTGCATCACGCTCAACCT
    GGTCGAGCAAGTGGTTTTTGTATATACAATGATATTGCAATTACCGCACAATACTTAGCT
    AAAGAATACAATCAACGCGTTTTAATCATAGATACCGATGCACATCATGGAGATGGTACA
    CAATGGAGTTTCTATGCCGATAACCATGTTACTACTTATTCTATCCATGAAACCGGAAAA
    TTTCTTTTCCCAGGCTCTGGTCACTATACTGAGCGCGGTGAAGATATCGGCTATGGACAC
    ACTGTAAATGTCCCACTTGAACCGTATACAGAAGATGCATCATTTTTGGAGTGTTTTAAA
    TTAACAGTTGAGCCTGTCGTAAAGAGTTTTAAACCTGATATTATTCTAAGCGTAAATGGT
    GTCGATATACATTATCGTGATCCACTAACTCATCTAAATTGTACGTTACATTCATTATAT
    GAAATTCCATATTTTGTAAAATATTTAGCTGATTCTTATACGAATGGAAAGGTAATTATG
    TTTGGTGGCGGAGGCTACAATATTTGGAGAGTCGTACCACGTGCATGGAGTCATGTATTC
    TTAAGTTTAATTGATCAACCAATTCAAAGTGGTTATTTACCGTTAGAATGGATTAATAAA
    TGGAAACATTATTCATCTGAATTATTACCTAAAAGATGGGAAGATCGTTTAAATGATTAT
    ACCTATGTCCCCCGCACAAAAGAAATTAGTGAAAAAAATAAAAAATTAGCTTTACATATA
    GCGAGTTGGTACGAATCTACTCGTCAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1170

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: SAUSA300_1681 [new locus tag: SAUSA300_RS09180 ]
  • symbol: AcuC
  • description: acetoin utilization protein AcuC
  • length: 389
  • theoretical pI: 6.79824
  • theoretical MW: 44629.1
  • GRAVY: -0.42365

Function[edit source | edit]

  • reaction:
    EC 1.2.4.1?  ExPASy
    Pyruvate dehydrogenase (acetyl-transferring)Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
  • TIGRFAM:
  • TheSEED:  
    CarbohydratesCentral carbohydrate metabolismPyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate NAD-independent protein deacetylase AcuC 
  • PFAM:
    Arginase (CL0302) Hist_deacetyl; Histone deacetylase domain (PF00850; HMM-score: 247.3)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular Possibility: 1
    • Signal Peptide Possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • Ymax: 0.118
    • Ymax_pos: 54
    • Cmax: 0.113
    • Cmax_pos: 54
    • Smax: 0.199
    • Smax_pos: 1
    • Smean: 0.098
    • D: 0.11
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit source | edit]

Protein sequence[edit source | edit]

  • MQQHSSKTAYVYSDKLLQYRFHDQHPFNQMRLKLTTELLLNANLLSPEQIVQPRIATDDELMLIHKYDYVEAIKHASHGIISEDEAKKYGLNDEENGQFKHMHRHSATIVGGALTLADLIMSGKVLNGCHLGGGLHHAQPGRASGFCIYNDIAITAQYLAKEYNQRVLIIDTDAHHGDGTQWSFYADNHVTTYSIHETGKFLFPGSGHYTERGEDIGYGHTVNVPLEPYTEDASFLECFKLTVEPVVKSFKPDIILSVNGVDIHYRDPLTHLNCTLHSLYEIPYFVKYLADSYTNGKVIMFGGGGYNIWRVVPRAWSHVFLSLIDQPIQSGYLPLEWINKWKHYSSELLPKRWEDRLNDYTYVPRTKEISEKNKKLALHIASWYESTRQ

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

Regulation[edit source | edit]

  • sigma factor:
  • regulators: CcpA, CodY
    CcpA (TF) important in Carbon catabolism  RegPrecise    transcription unit transferred from N315 data RegPrecise
    CodY (TF) important in Amino acid metabolism  RegPrecise    transcription unit transferred from N315 data RegPrecise

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]