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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_002331
  • pan locus tag?: SAUPAN005871000
  • symbol: hssS
  • pan gene symbol?: hssS
  • synonym:
  • product: heme sensor histidine kinase HssS

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_002331
  • symbol: hssS
  • product: heme sensor histidine kinase HssS
  • replicon: chromosome
  • strand: +
  • coordinates: 2327952..2329325
  • length: 1374
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGTTTAAAACACTCTATGCTAGAATTGCGATTTATTCCATTACGGTTATTTTATTTAGT
    GCATTAATAAGTTTTGTATTAACAAATGTTTACTATCATTATAATTTAAAAGCATCTAAT
    GACGCGAAAATCATGAAGACGCTTAAAGAAGCAAGACAATATGAACAATCAGCTAAACCA
    ACGCACATTCAACAATATTTCAAACATTTAGGGCAAATGAATTACCAAATAATGACCGTT
    GATCAAAAAGGTCATAAGACATTTTATGGGGAGCCATTTAGAGAAGATACTTTATCACAA
    AATGCTATTAACAACGTATTAAATAATCAAGATTACCATGGTATTAAAGATAAACCATTC
    GCATTATTCGTAACTGGATTTTTCGACAATGTAACAGATAATACTGTTGGTATTAACTTT
    AAGACAAAAGACGGTTCAATAGCAGTATTTATGCGTCCAGATATTGGAGAAACATTTAGC
    GAGTTTAGAACATTCTTAGCCGTCTTGTTAATGTTGTTATTATTTATCTCGATTTCATTA
    GTTATCGCATCAACCTATTCAATCATTCGTCCAGTAAAAAAGTTAAAGCTAGCGACCGAA
    CGCTTAATTGAAGGTGATTTTGAAACGCCTATCAAACAAACACGAAAAGATGAAATTGGA
    ACATTACAGTATCACTTTAATAAGATGAGAGAGTCGTTGGGACAGGTCGATCAAATGAGA
    CAACATTTCGTACAAAATGTATCTCATGAAATCAAAACACCATTAACACATATTCATCAT
    TTATTAAGCGAGTTACAACAAACTTCTGATAAAACATTACGCCAACAATATATAAATGAT
    ATTTATAGCATTACAACACAGCTGAGTGGATTAACAACTGAATTGTTACTTTTATCTGAA
    TTAGATAATCACCAACATTTATCATTCGACGATAAGATACAAGTCGATCAACTCATTAAA
    GAGATCATTCGTCACGAGCAATTTGCTGCTGATGAAAAGTCGTTAATTATTTTAGCTGAC
    CTAGAATCAATCAATTTCCTAGGAAATCAACGTTTGTTAAATCAAGCATTGAGTAATTTA
    TTAATAAATGCTATTAAGTATACAGATGTTGGTGGTGCCATTGACATCGCTTTGCAACAT
    AGTCACAACAACATCATTTTCACAATAAGTAATGATGGTTCACCAATTAGTCCACAAGCT
    GAAGCACGTTTATTTGAACGTTTTTATAAAGTGAGCAAACATGATAATAGCAATGGTTTA
    GGTCTTGCAATTACAAAATCCATCATTGAATTGCATCATGGTACAATCCAATTCACACAA
    AGTAACGAGTACGTAACCACCTTTACTATTACACTGCCAAATAATTCACATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1374

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_002331
  • symbol: HssS
  • description: heme sensor histidine kinase HssS
  • length: 457
  • theoretical pI: 7.1
  • theoretical MW: 52350.4
  • GRAVY: -0.208753

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Signal transduction Two-component systems phosphate regulon sensor kinase PhoR (TIGR02966; EC 2.7.3.-; HMM-score: 159.3)
    heavy metal sensor kinase (TIGR01386; EC 2.7.13.3; HMM-score: 148.4)
    and 6 more
    proteobacterial dedicated sortase system histidine kinase (TIGR03785; HMM-score: 104)
    Signal transduction Signal transduction Two-component systems TMAO reductase sytem sensor TorS (TIGR02956; EC 2.7.13.3; HMM-score: 87.4)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking putative PEP-CTERM system histidine kinase (TIGR02916; EC 2.7.13.3; HMM-score: 49.8)
    Signal transduction Signal transduction Two-component systems putative PEP-CTERM system histidine kinase (TIGR02916; EC 2.7.13.3; HMM-score: 49.8)
    Metabolism Central intermediary metabolism Nitrogen fixation nitrogen fixation negative regulator NifL (TIGR02938; HMM-score: 17.3)
    Signal transduction Regulatory functions Protein interactions nitrogen fixation negative regulator NifL (TIGR02938; HMM-score: 17.3)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    His_Kinase_A (CL0025) HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518; HMM-score: 79.9)
    and 6 more
    HisKA; His Kinase A (phospho-acceptor) domain (PF00512; HMM-score: 41.5)
    HAMP (CL0681) HAMP; HAMP domain (PF00672; HMM-score: 41.1)
    His_Kinase_A (CL0025) HATPase_c_5; GHKL domain (PF14501; HMM-score: 27.2)
    HATPase_c_2; Histidine kinase-like ATPase domain (PF13581; HMM-score: 16.8)
    no clan defined Sigma_reg_N; Sigma factor regulator N-terminal (PF13800; HMM-score: 13.4)
    SAPIS-gp6; Pathogenicity island protein gp6 in Staphylococcus (PF16722; HMM-score: 9.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.01
    • Cytoplasmic Membrane Score: 9.99
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 2
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.9987
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0013
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.09055
    • TAT(Tat/SPI): 0.000758
    • LIPO(Sec/SPII): 0.027154
  • predicted transmembrane helices (TMHMM): 2

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MFKTLYARIAIYSITVILFSALISFVLTNVYYHYNLKASNDAKIMKTLKEARQYEQSAKPTHIQQYFKHLGQMNYQIMTVDQKGHKTFYGEPFREDTLSQNAINNVLNNQDYHGIKDKPFALFVTGFFDNVTDNTVGINFKTKDGSIAVFMRPDIGETFSEFRTFLAVLLMLLLFISISLVIASTYSIIRPVKKLKLATERLIEGDFETPIKQTRKDEIGTLQYHFNKMRESLGQVDQMRQHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIYSITTQLSGLTTELLLLSELDNHQHLSFDDKIQVDQLIKEIIRHEQFAADEKSLIILADLESINFLGNQRLLNQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDNSNGLGLAITKSIIELHHGTIQFTQSNEYVTTFTITLPNNSH

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Blanca Taboada, Karel Estrada, Ricardo Ciria, Enrique Merino
    Operon-mapper: a web server for precise operon identification in bacterial and archaeal genomes.
    Bioinformatics: 2018, 34(23);4118-4120
    [PubMed:29931111] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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