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NCBI: 02-MAR-2017

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_RS03010 [old locus tag: NWMN_0519 ]
  • pan locus tag?: SAUPAN002330000
  • symbol: NWMN_RS03010
  • pan gene symbol?: dgk
  • synonym:
  • product: deoxynucleoside kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: NWMN_RS03010 [old locus tag: NWMN_0519 ]
  • symbol: NWMN_RS03010
  • product: deoxynucleoside kinase
  • replicon: chromosome
  • strand: -
  • coordinates: 598481..599098
  • length: 618
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_009641 (598481..599098) NCBI
  • BioCyc:
  • MicrobesOnline: see NWMN_0519

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGAACAAACCTTTTATAGCAATTGAAGGTCCTATTGGCGTAGGTAAATCTTCACTTGCA
    CACAAATTAAGTCAAACTTTAGATTTTTATGAAGAAAAAGAAATCATCACAGAAAATCCA
    TTTTTATCAGACTTTTATGAAGATATCTCTAAATGGAGTTTTCAAACTGAAATGTTCTTT
    TTATGCAATAGATATAAGCAATTTCAAGATGTAACACAACTAAATCAAGGTGTAGTTAGT
    GATTATCATATACATAAAAATAAGATATTTGCTAAAAATACTTTGAGTTCTGTTGAATTT
    CAGAAATTCAGTAAAATTTATGATATTTTAACTGAAGATATGATTATGCCGAATATGATT
    ATCTTTTTAGATGCAGACCTTGATGTGTTAAAATCTAGAATTGCTAAACGTAACCGTAGT
    TTTGAGCATCAAATAGAAGATGAATATCTGTTAAAGTTAAAAAAAGATTATCGTGAGTAT
    TATGAGTCCTTACAAAGTAATGGTTCAAATGTAGTTTTAATCGATACAACTTCTATTGAT
    TTTCTTAAAAATGAACAAGATTACGAAGATATATTACATATTATATTACCTATGATAGGA
    GATATTACCAATGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    618

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: NWMN_RS03010 [old locus tag: NWMN_0519 ]
  • symbol: NWMN_RS03010
  • description: deoxynucleoside kinase
  • length: 205
  • theoretical pI: 4.5954
  • theoretical MW: 24153.3
  • GRAVY: -0.377073

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions dTMP kinase (TIGR00041; EC 2.7.4.9; HMM-score: 44)
    and 5 more
    putative cytidylate kinase (TIGR02173; EC 2.7.4.14; HMM-score: 25.1)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions cytidylate kinase (TIGR00017; EC 2.7.4.14; HMM-score: 20.5)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions guanylate kinase (TIGR03263; EC 2.7.4.8; HMM-score: 16.4)
    Metabolism Central intermediary metabolism Phosphorus compounds phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN (TIGR02322; HMM-score: 15.8)
    carbohydrate kinase, thermoresistant glucokinase family (TIGR01313; EC 2.7.1.-; HMM-score: 12.4)
  • TheSEED: data available for COL, N315, NCTC8325, USA300_FPR3757
  • PFAM:
    P-loop_NTPase (CL0023) dNK; Deoxynucleoside kinase (PF01712; HMM-score: 155.8)
    and 16 more
    Thymidylate_kin; Thymidylate kinase (PF02223; HMM-score: 39.9)
    AAA_18; AAA domain (PF13238; HMM-score: 34.5)
    AAA_33; AAA domain (PF13671; HMM-score: 31)
    Cytidylate_kin; Cytidylate kinase (PF02224; HMM-score: 18.7)
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 17.9)
    SKI; Shikimate kinase (PF01202; HMM-score: 17.9)
    AAA_22; AAA domain (PF13401; HMM-score: 17.9)
    AAA_17; AAA domain (PF13207; HMM-score: 15.6)
    RNA_helicase; RNA helicase (PF00910; HMM-score: 15.3)
    AAA_14; AAA domain (PF13173; HMM-score: 14.8)
    ABC_tran; ABC transporter (PF00005; HMM-score: 14.2)
    AAA_28; AAA domain (PF13521; HMM-score: 13.5)
    MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 12.8)
    NACHT; NACHT domain (PF05729; HMM-score: 12.8)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 12.4)
    PreATP-grasp (CL0483) GSH_synth_ATP; Eukaryotic glutathione synthase, ATP binding domain (PF03917; HMM-score: 11.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.006391
    • TAT(Tat/SPI): 0.000277
    • LIPO(Sec/SPII): 0.000894
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MNKPFIAIEGPIGVGKSSLAHKLSQTLDFYEEKEIITENPFLSDFYEDISKWSFQTEMFFLCNRYKQFQDVTQLNQGVVSDYHIHKNKIFAKNTLSSVEFQKFSKIYDILTEDMIMPNMIIFLDADLDVLKSRIAKRNRSFEHQIEDEYLLKLKKDYREYYESLQSNGSNVVLIDTTSIDFLKNEQDYEDILHIILPMIGDITNE

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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