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NCBI: 10-JUN-2013
⊟Summary[edit | edit source]
- organism: Staphylococcus aureus COL
- locus tag: SACOL0420 [new locus tag: SACOL_RS02115 ]
- pan locus tag?: SAUPAN001892000
- symbol: SACOL0420
- pan gene symbol?: —
- synonym:
- product: Cro/CI family transcriptional regulator
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SACOL0420 [new locus tag: SACOL_RS02115 ]
- symbol: SACOL0420
- product: Cro/CI family transcriptional regulator
- replicon: chromosome
- strand: +
- coordinates: 425482..425685
- length: 204
- essential: unknown other strains
⊟Accession numbers[edit | edit source]
- Gene ID: 3236510 NCBI
- RefSeq: YP_185312 NCBI
- BioCyc: see SACOL_RS02115
- MicrobesOnline: 911891 MicrobesOnline
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
61
121
181GTGCGTAATCGATTGAAAGAATTACGAGCACGAGATGGCTTAAACCAAACGCAACTTGCT
AAACAAGCGGGCGTTTCAAGACAAACCATATCGCTAATTGAGCGAAACAATTTTATGCCA
TCAGTATTAACGGCAATAAAAATTGCTCGCATTTTCAATGAAACGGTGGAAACTGTTTTT
ATTATTGAGGAGGATGAGGCATGA60
120
180
204
⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SACOL0420 [new locus tag: SACOL_RS02115 ]
- symbol: SACOL0420
- description: Cro/CI family transcriptional regulator
- length: 67
- theoretical pI: 9.43033
- theoretical MW: 7688.8
- GRAVY: -0.304478
⊟Function[edit | edit source]
- TIGRFAM: Regulatory functions DNA interactions transcriptional regulator, y4mF family (TIGR03070; HMM-score: 33.5)and 7 moreMobile and extrachromosomal element functions Other addiction module antidote protein, HigA family (TIGR02607; HMM-score: 22.7)Regulatory functions DNA interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 22.7)Regulatory functions Protein interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 22.7)Regulatory functions DNA interactions DNA-binding protein, Tfx family (TIGR00721; HMM-score: 20.3)putative zinc finger/helix-turn-helix protein, YgiT family (TIGR03830; HMM-score: 18)Unknown function General mobile mystery protein A (TIGR02612; HMM-score: 17.5)RNA polymerase sigma factor, sigma-70 family (TIGR02937; HMM-score: 14.6)
- TheSEED :
- Transcriptional regulator, Cro/CI family
- PFAM: HTH (CL0123) HTH_3; Helix-turn-helix (PF01381; HMM-score: 56.5)HTH_19; Helix-turn-helix domain (PF12844; HMM-score: 46)and 19 moreHTH_31; Helix-turn-helix domain (PF13560; HMM-score: 35.4)HTH_26; Cro/C1-type HTH DNA-binding domain (PF13443; HMM-score: 26.4)HTH_7; Helix-turn-helix domain of resolvase (PF02796; HMM-score: 22.6)Sigma70_r4; Sigma-70, region 4 (PF04545; HMM-score: 22.6)HTH_38; Helix-turn-helix domain (PF13936; HMM-score: 19.7)HTH_23; Homeodomain-like domain (PF13384; HMM-score: 18.9)MarR_2; MarR family (PF12802; HMM-score: 18.4)HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 18.4)LacI; Bacterial regulatory proteins, lacI family (PF00356; HMM-score: 18.3)HTH_25; Helix-turn-helix domain (PF13413; HMM-score: 18.2)MarR; MarR family (PF01047; HMM-score: 17)HTH_11; HTH domain (PF08279; HMM-score: 17)Phage_CI_repr; Bacteriophage CI repressor helix-turn-helix domain (PF07022; HMM-score: 15.9)HTH_37; Helix-turn-helix domain (PF13744; HMM-score: 14.1)HTH_Crp_2; Crp-like helix-turn-helix domain (PF13545; HMM-score: 13.9)HTH_29; Winged helix-turn helix (PF13551; HMM-score: 13.9)HTH_28; Helix-turn-helix domain (PF13518; HMM-score: 13.6)no clan defined TnsD; Tn7-like transposition protein D (PF15978; HMM-score: 13.4)HTH (CL0123) YdaS_antitoxin; Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT (PF15943; HMM-score: 12.8)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 7.5
- Cytoplasmic Membrane Score: 1.15
- Cellwall Score: 0.62
- Extracellular Score: 0.73
- Internal Helices: 0
- LocateP: Intracellular
- Prediction by SwissProt Classification: Cytoplasmic
- Pathway Prediction: No pathway
- Intracellular possibility: 1
- Signal peptide possibility: -1
- N-terminally Anchored Score: 1
- Predicted Cleavage Site: No CleavageSite
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.002333
- TAT(Tat/SPI): 0.001565
- LIPO(Sec/SPII): 0.000634
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MRNRLKELRARDGLNQTQLAKQAGVSRQTISLIERNNFMPSVLTAIKIARIFNETVETVFIIEEDEA
⊟Experimental data[edit | edit source]
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription pattern[edit | edit source]
- S.aureus Expression Data Browser: data available for NCTC8325
⊟Protein synthesis (provided by Aureolib)[edit | edit source]
- Aureolib: no data available
⊟Protein stability[edit | edit source]
- half-life: no data available
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Andreas Otto, Jan Maarten van Dijl, Michael Hecker, Dörte Becher
The Staphylococcus aureus proteome.
Int J Med Microbiol: 2014, 304(2);110-20
[PubMed:24439828] [WorldCat.org] [DOI] (I p) - ↑ Daniela Zühlke, Kirsten Dörries, Jörg Bernhardt, Sandra Maaß, Jan Muntel, Volkmar Liebscher, Jan Pané-Farré, Katharina Riedel, Michael Lalk, Uwe Völker, Susanne Engelmann, Dörte Becher, Stephan Fuchs, Michael Hecker
Costs of life - Dynamics of the protein inventory of Staphylococcus aureus during anaerobiosis.
Sci Rep: 2016, 6;28172
[PubMed:27344979] [WorldCat.org] [DOI] (I e)