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NCBI: 10-JUN-2013

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL1182 [new locus tag: SACOL_RS06045 ]
  • pan locus tag?: SAUPAN003430000
  • symbol: arcC1
  • pan gene symbol?: arcC1
  • synonym:
  • product: carbamate kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SACOL1182 [new locus tag: SACOL_RS06045 ]
  • symbol: arcC1
  • product: carbamate kinase
  • replicon: chromosome
  • strand: +
  • coordinates: 1186421..1187353
  • length: 933
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGGCGAAAATAGTAGTAGCATTAGGTGGTAATGCTTTAGGAAAATCACCTCAAGAACAA
    CTCGAGCTTGTTAAAAATACTGCGAAATCATTAGTAGGATTAATAACAAAAGGACATGAG
    ATTGTTATTAGTCATGGTAATGGACCACAGGTTGGAAGCATTAATTTGGGACTTAACTAT
    GCTGCAGAACATAACCAAGGTCCGGCATTTCCATTTGCTGAATGTGGCGCAATGAGTCAA
    GCTTACATCGGCTATCAATTACAAGAAAGCTTACAAAATGAATTGCATTCTATTGGAATG
    GATAAACAAGTGGTAACACTAGTGACACAAGTTGAAGTTGATGAAAATGATCCGGCATTT
    AACAATCCTTCAAAACCAATTGGGTTATTTTACAACAAAGAAGAAGCTGAACAAATTCAA
    AAAGAAAAAGGATTTATATTTGTTGAAGATGCTGGAAGAGGATATAGACGCGTTGTTCCT
    TCACCACAACCCATCTCTATTATTGAATTAGAGAGTATTAAAACACTTATTAAAAATGAT
    ACACTCGTTATTGCTGCTGGTGGTGGAGGTATACCAGTAATTAGAGAGCAACATGATGGT
    TTTAAAGGTATTGATGCAGTTATAGACAAAGATAAAACAAGTGCGTTGTTGGGTGCTAAT
    ATTCAATGCGATCAATTGATTATTTTAACAGCAATTGATTATGTATATATTAATTTTAAC
    ACTGAAAACCAACAGCCTTTGAAAACAACAAATGTTGATGAATTAAAACGATATATAGAC
    GAAAATCAATTTGCAAAAGGAAGTATGTTACCAAAAATTGAAGCAGCCATATCATTTATT
    GAAAACAATCCAAAAGGAAGTGTGCTTATAACATCATTAAATGAATTAGATGCTGCCTTA
    GAGGGTAAAGTAGGTACTGTGATTAAAAAGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    933

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SACOL1182 [new locus tag: SACOL_RS06045 ]
  • symbol: ArcC1
  • description: carbamate kinase
  • length: 310
  • theoretical pI: 4.84797
  • theoretical MW: 33596.1
  • GRAVY: -0.157419

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.2.2?  ExPASy
    Carbamate kinase ATP + NH3 + CO2 = ADP + carbamoyl phosphate
  • TIGRFAM:
    Metabolism Energy metabolism Amino acids and amines carbamate kinase (TIGR00746; EC 2.7.2.2; HMM-score: 384.5)
    and 5 more
    Metabolism Amino acid biosynthesis Glutamate family acetylglutamate kinase (TIGR00761; EC 2.7.2.8; HMM-score: 35.9)
    Metabolism Amino acid biosynthesis Glutamate family glutamate 5-kinase (TIGR01027; EC 2.7.2.11; HMM-score: 22.1)
    Metabolism Amino acid biosynthesis Glutamate family delta l-pyrroline-5-carboxylate synthetase (TIGR01092; HMM-score: 16.4)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions putative uridylate kinase (TIGR02076; EC 2.7.4.-; HMM-score: 16.3)
    cyanobactin biosynthesis protein, PatB/AcyB/McaB family (TIGR04220; HMM-score: 11.5)
  • TheSEED  :
    • Carbamate kinase (EC 2.7.2.2)
    Amino Acids and Derivatives Arginine; urea cycle, polyamines Arginine and Ornithine Degradation  Carbamate kinase (EC 2.7.2.2)
    and 2 more
    Amino Acids and Derivatives Arginine; urea cycle, polyamines Arginine Deiminase Pathway  Carbamate kinase (EC 2.7.2.2)
    Amino Acids and Derivatives Arginine; urea cycle, polyamines Polyamine Metabolism  Carbamate kinase (EC 2.7.2.2)
  • PFAM:
    no clan defined AA_kinase; Amino acid kinase family (PF00696; HMM-score: 99.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular possibility: 1
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.02881
    • TAT(Tat/SPI): 0.000849
    • LIPO(Sec/SPII): 0.00301
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MAKIVVALGGNALGKSPQEQLELVKNTAKSLVGLITKGHEIVISHGNGPQVGSINLGLNYAAEHNQGPAFPFAECGAMSQAYIGYQLQESLQNELHSIGMDKQVVTLVTQVEVDENDPAFNNPSKPIGLFYNKEEAEQIQKEKGFIFVEDAGRGYRRVVPSPQPISIIELESIKTLIKNDTLVIAAGGGGIPVIREQHDGFKGIDAVIDKDKTSALLGANIQCDQLIILTAIDYVYINFNTENQQPLKTTNVDELKRYIDENQFAKGSMLPKIEAAISFIENNPKGSVLITSLNELDAALEGKVGTVIKK

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for NCTC8325
  • protein localization: Cytoplasmic [1]
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Andreas Otto, Jan Maarten van Dijl, Michael Hecker, Dörte Becher
    The Staphylococcus aureus proteome.
    Int J Med Microbiol: 2014, 304(2);110-20
    [PubMed:24439828] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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