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NCBI: 03-AUG-2016
⊟Summary[edit | edit source]
- organism: Staphylococcus aureus NCTC8325
- locus tag: SAOUHSC_00584
- pan locus tag?: SAUPAN002442000
- symbol: SAOUHSC_00584
- pan gene symbol?: tspA
- synonym:
- product: hypothetical protein
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SAOUHSC_00584
- symbol: SAOUHSC_00584
- product: hypothetical protein
- replicon: chromosome
- strand: +
- coordinates: 585426..586835
- length: 1410
- essential: no DEG other strains
⊟Accession numbers[edit | edit source]
- Gene ID: 3920508 NCBI
- RefSeq: YP_499151 NCBI
- BioCyc: G1I0R-549 BioCyc
- MicrobesOnline: 1289061 MicrobesOnline
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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1381ATGAGTATTGACATGTATTTAGACAGATCTCGAAACCAAGCTTCAAGTGTGGGGAATTTG
AGTCAAACAATGAATTCAAATTATGATGCGTTGGAAAAAGCAATTACTCAATTTATTAAT
GATGATGCGCTTAAAGGGAAAGCGTATACGTCAGCTAAGCAATTTTTTAGTACGGTGTTA
ATTCCATTATCAACAAGTATGAAAACATTGAGTGATTTAACGAAGCAAGCTTGCGATAAT
TTTGTGTCACGTTATACGAGTGAGGTTGATAGCATATCTTTAAAAGAATCAGAGCTTGAA
GAAGATATCAGATCATTAAGTCAACAAATTACGCGATATGAAAATTTGAATAACAATTTG
AAAAAGCATGCTTCCGATAATCAGCAAGCCATTTCATCGAACCAACAAATAATACGAACA
TTAGGTCAACAAAAACATGAATTAGAAGAGAAGCTACGCAAATTGCGTGAGTTTAATCAA
AAATCACCAGAAATATTTAAAGAAGTTGAAGAATTTCAAAAAATTGTCCAACAAGGACTT
ACCCAAGCGCAGAATTTTTGGAACTTTTCAACAAATCAATTTAATATTCCTTCAGGTAAA
GAACTTGATTGGGCCAAAGCAAGTCATGAAAAATATTTGAAAGTTGCTATGGGGAAAATT
GAACATAAAGCAGAGAAAGAAACTTTAAATAAAGCAGACTTTGCTGTTATAAAGGCATAT
GCCAAAGAACATCCAGAAGACGATATCCCGAAAAGTATATTGAAATATATAAATGACAAT
AAAGACAGTATTAAAAGAGATATAGGATTAGATATTACGTCAACACTTTTAGAGCAAGAC
GGTATAAATGCAAGTAAATTCGGTGTATTTATCAATACAGCAGGTGGAGTGAAAGGCCCA
GCAGGTCCAAATTCATTTGTGGAAGTCAAACGTACATCAGGTAATGTGTTTATAGAAAAT
GGTAGTAAATTTGCAAAAGGCGGAAAATACCTAGGTAAAGGTGTTGCTGGTGTAGGATTT
GGTATAGGTATGTATGATGACCTTGCAAATGATGATAAAACATTTGGAGAGGCGTTGTCG
CATAATGGTATGACGCTTGCAGCTGGATCTGCAGGGACAGCAGTTGGAGCTGGATTAGCG
ACTTTTGTTTTAGGAAGTAATCCAGTAGGATGGGTGATTTTAGCAGGTTTGGCTATGAGT
ACAGTATTTGCATTAGGAACAGATTTAATTTATCAAAATAATATTTTTGGATTAAAAGAT
AAAGTAGACTGGGTAGGGCATAAAATCGATAATAGTATAGATGTTGTTAAAAAAACTACA
GAAAAATCCATGGATAGTGTTGGGAATGCTGTTAGTGAAGCTAAAAATATTATTAGCAAT
CATATAAATCCAATGAAATGGGCGTGGTGA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SAOUHSC_00584
- symbol: SAOUHSC_00584
- description: hypothetical protein
- length: 469
- theoretical pI: 6.97557
- theoretical MW: 51668.9
- GRAVY: -0.43177
⊟Function[edit | edit source]
- TIGRFAM: SH3 domain protein (TIGR04211; HMM-score: 15.3)Cellular processes Cell division chromosome segregation protein SMC (TIGR02169; HMM-score: 14)DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02169; HMM-score: 14)Cellular processes Cell division chromosome segregation protein SMC (TIGR02168; HMM-score: 12.9)DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02168; HMM-score: 12.9)and 3 moreProtein fate Protein and peptide secretion and trafficking type I secretion membrane fusion protein, HlyD family (TIGR01843; HMM-score: 7.1)two transmembrane protein (TIGR04527; HMM-score: 5.4)Mobile and extrachromosomal element functions Prophage functions phage tail tape measure protein, lambda family (TIGR01541; HMM-score: 4.2)
- TheSEED :
- hypothetical fig|282458.1.peg.573 homolog
- PFAM: EsxAB (CL0352) LXG; LXG domain of WXG superfamily (PF04740; HMM-score: 37.8)and 32 moreno clan defined DUF3450; Protein of unknown function (DUF3450) (PF11932; HMM-score: 19.9)Mce4_CUP1; Cholesterol uptake porter CUP1 of Mce4, putative (PF11887; HMM-score: 17.3)Concanavalin (CL0004) Laminin_II; Laminin Domain II (PF06009; HMM-score: 17.2)Tropomyosin-lke (CL0452) Tropomyosin; Tropomyosin (PF00261; HMM-score: 16.5)no clan defined DegS; Sensor protein DegS (PF05384; HMM-score: 15.1)Apolipoprotein (CL0725) ApoLp-III; Apolipophorin-III precursor (apoLp-III) (PF07464; HMM-score: 13.9)Ferritin (CL0044) DUF892; Domain of unknown function (DUF892) (PF05974; HMM-score: 13.7)no clan defined CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like (PF07888; HMM-score: 13.3)DUF1664; Protein of unknown function (DUF1664) (PF07889; HMM-score: 11.9)APG6_N; Apg6 coiled-coil region (PF17675; HMM-score: 11.9)DUF5740; Family of unknown function (DUF5740) (PF19011; HMM-score: 11.5)Acetyltransf_11; Udp N-acetylglucosamine O-acyltransferase; Domain 2 (PF13720; HMM-score: 11.4)DUF4200; Domain of unknown function (DUF4200) (PF13863; HMM-score: 11.1)ADIP; Afadin- and alpha -actinin-Binding (PF11559; HMM-score: 10.7)GT-B (CL0113) FUT8_N_cat; Alpha-(1,6)-fucosyltransferase N- and catalytic domains (PF19745; HMM-score: 10.7)HTH (CL0123) RBD_LARS1; Leucine--tRNA ligase, RagD-binding domain (PF24810; HMM-score: 10.4)TPR (CL0020) COG6_N; Conserved oligomeric complex COG6, N-terminal (PF06419; HMM-score: 10.2)CorA-like (CL0788) CorA; CorA-like Mg2+ transporter protein (PF01544; HMM-score: 10.1)no clan defined ADAMTSL1; ADAMTSL1 domain (PF24484; HMM-score: 10.1)Mis12; Mis12 protein (PF05859; HMM-score: 9.9)Laminin_I; Laminin Domain I (PF06008; HMM-score: 9.6)HTH (CL0123) Vir_act_alpha_C; Virulence activator alpha C-term (PF10400; HMM-score: 9.5)no clan defined NNH2; NACHT N-terminal Helical domain 2 (PF22734; HMM-score: 9.1)CC4_CEP85; Centrosomal protein of 85 kDa-like, CC4 coiled-coil domain (PF24555; HMM-score: 9.1)V_ATPase_I; V-type ATPase 116kDa subunit family (PF01496; HMM-score: 8.9)DUF2935; Domain of unknown function (DUF2935) (PF11155; HMM-score: 8.3)BLOC1_2; Biogenesis of lysosome-related organelles complex-1 subunit 2 (PF10046; HMM-score: 8.2)crAss001_48; crAss001_48 related protein (PF21825; HMM-score: 8.2)DivIVA; DivIVA protein (PF05103; HMM-score: 8.1)TMPIT; TMPIT-like protein (PF07851; HMM-score: 8.1)TSC22; TSC-22/dip/bun family (PF01166; HMM-score: 8)Exonuc_VII_L; Exonuclease VII, large subunit (PF02601; HMM-score: 6.9)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: unknown (no significant prediction)
- Cytoplasmic Score: 2.5
- Cytoplasmic Membrane Score: 2.5
- Cellwall Score: 2.5
- Extracellular Score: 2.5
- Internal Helices: 2
- DeepLocPro: Extracellular
- Cytoplasmic Score: 0.0001
- Cytoplasmic Membrane Score: 0.025
- Cell wall & surface Score: 0.002
- Extracellular Score: 0.9729
- LocateP: Multi-transmembrane
- Prediction by SwissProt Classification: Membrane
- Pathway Prediction: Sec-(SPI)
- Intracellular possibility: 0.17
- Signal peptide possibility: -1
- N-terminally Anchored Score: -1
- Predicted Cleavage Site: No CleavageSite
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.006641
- TAT(Tat/SPI): 0.001543
- LIPO(Sec/SPII): 0.000945
- predicted transmembrane helices (TMHMM): 1
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MSIDMYLDRSRNQASSVGNLSQTMNSNYDALEKAITQFINDDALKGKAYTSAKQFFSTVLIPLSTSMKTLSDLTKQACDNFVSRYTSEVDSISLKESELEEDIRSLSQQITRYENLNNNLKKHASDNQQAISSNQQIIRTLGQQKHELEEKLRKLREFNQKSPEIFKEVEEFQKIVQQGLTQAQNFWNFSTNQFNIPSGKELDWAKASHEKYLKVAMGKIEHKAEKETLNKADFAVIKAYAKEHPEDDIPKSILKYINDNKDSIKRDIGLDITSTLLEQDGINASKFGVFINTAGGVKGPAGPNSFVEVKRTSGNVFIENGSKFAKGGKYLGKGVAGVGFGIGMYDDLANDDKTFGEALSHNGMTLAAGSAGTAVGAGLATFVLGSNPVGWVILAGLAMSTVFALGTDLIYQNNIFGLKDKVDWVGHKIDNSIDVVKKTTEKSMDSVGNAVSEAKNIISNHINPMKWAW
⊟Experimental data[edit | edit source]
- experimentally validated: PeptideAtlas [1] [2]
- protein localization: data available for COL
- quantitative data / protein copy number per cell:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- predicted SigA promoter [3] : S216 > SAOUHSC_00584 > S217 > SAOUHSC_00585 > S218 > SAOUHSC_00586 > S219 > SAOUHSC_00587 > SAOUHSC_00588 > SAOUHSC_00589 > SAOUHSC_00591 > SAOUHSC_00592 > SAOUHSC_00593
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription pattern[edit | edit source]
- S.aureus Expression Data Browser: [3] Multi-gene expression profiles
⊟Protein synthesis (provided by Aureolib)[edit | edit source]
- Aureolib: no data available
⊟Protein stability[edit | edit source]
- half-life: no data available
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Maren Depke, Stephan Michalik, Alexander Rabe, Kristin Surmann, Lars Brinkmann, Nico Jehmlich, Jörg Bernhardt, Michael Hecker, Bernd Wollscheid, Zhi Sun, Robert L Moritz, Uwe Völker, Frank Schmidt
A peptide resource for the analysis of Staphylococcus aureus in host-pathogen interaction studies.
Proteomics: 2015, 15(21);3648-61
[PubMed:26224020] [WorldCat.org] [DOI] (I p) - ↑ Stephan Michalik, Maren Depke, Annette Murr, Manuela Gesell Salazar, Ulrike Kusebauch, Zhi Sun, Tanja C Meyer, Kristin Surmann, Henrike Pförtner, Petra Hildebrandt, Stefan Weiss, Laura Marcela Palma Medina, Melanie Gutjahr, Elke Hammer, Dörte Becher, Thomas Pribyl, Sven Hammerschmidt, Eric W Deutsch, Samuel L Bader, Michael Hecker, Robert L Moritz, Ulrike Mäder, Uwe Völker, Frank Schmidt
A global Staphylococcus aureus proteome resource applied to the in vivo characterization of host-pathogen interactions.
Sci Rep: 2017, 7(1);9718
[PubMed:28887440] [WorldCat.org] [DOI] (I e) - ↑ 3.0 3.1 Ulrike Mäder, Pierre Nicolas, Maren Depke, Jan Pané-Farré, Michel Debarbouille, Magdalena M van der Kooi-Pol, Cyprien Guérin, Sandra Dérozier, Aurelia Hiron, Hanne Jarmer, Aurélie Leduc, Stephan Michalik, Ewoud Reilman, Marc Schaffer, Frank Schmidt, Philippe Bessières, Philippe Noirot, Michael Hecker, Tarek Msadek, Uwe Völker, Jan Maarten van Dijl
Staphylococcus aureus Transcriptome Architecture: From Laboratory to Infection-Mimicking Conditions.
PLoS Genet: 2016, 12(4);e1005962
[PubMed:27035918] [WorldCat.org] [DOI] (I e)