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NCBI: 03-AUG-2016
⊟Summary[edit | edit source]
- organism: Staphylococcus aureus NCTC8325
- locus tag: SAOUHSC_01175
- pan locus tag?: SAUPAN003490000
- symbol: SAOUHSC_01175
- pan gene symbol?: rqcH
- synonym:
- product: fibrinogen-binding protein A-like protein
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SAOUHSC_01175
- symbol: SAOUHSC_01175
- product: fibrinogen-binding protein A-like protein
- replicon: chromosome
- strand: -
- coordinates: 1124879..1126576
- length: 1698
- essential: no DEG other strains
⊟Accession numbers[edit | edit source]
- Gene ID: 3920926 NCBI
- RefSeq: YP_499714 NCBI
- BioCyc: G1I0R-1101 BioCyc
- MicrobesOnline: 1289628 MicrobesOnline
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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1681ATGGCTTATGATGGCTTATTTACAAAGAAAATGGTTGAGTCTCTACAATTTTTAACAACA
GGACGTGTTCACAAAATCAATCAACCTGATAATGACACGATACTAATGGTTGTACGTCAA
AATAGACAAAACCATCAATTGTTATTGTCAATCCATCCAAACTTTTCAAGATTACAATTG
ACTACTAAAAAATATGATAATCCATTTAATCCACCCATGTTTGCGCGTGTTTTTAGAAAA
CACTTAGAAGGTGGTATTATCGAATCGATTAAGCAAATTGGTAATGATCGTCGCATTGAA
ATCGATATAAAGAGTAAAGATGAAATTGGCGATACTATTTACCGCACTGTCATCCTTGAG
ATTATGGGTAAACATAGTAACTTAATTTTAGTAGATGAAAATCGCAAAATAATTGAAGGA
TTTAAACACTTAACACCAAATACGAATCACTATCGTACAGTAATGCCAGGATTTAATTAT
GAAGCACCACCTACTCAGCACAAAATAAATCCGTATGATATTACAGGTGCAGAGGTGTTG
AAATATATCGATTTTAACGCAGGTAATATTGCTAAACAATTATTGAATCAGTTTGAAGGA
TTTAGCCCTTTAATTACGAATGAAATCGTTAGTCGTCGTCAATTTATGACTTCATCAACA
TTACCAGAAGCATTTGACGAAGTAATGGCAGAAACCAAGTTACCACCTACTCCTATTTTT
CATAAAAATCATGAAACAGGTAAAGAGGATTTCTATTTTATAAAGTTAAATCAATTTAAT
GATGATACAGTTACATACGATTCATTAAATGATTTGCTTGATCGTTTTTATGATGCGCGT
GGCGAACGTGAACGCGTTAAACAACGTGCGAATGATTTAGTTCGATTTGTTCAACAGCAG
TTGCACAAATATCAAAATAAATTAGCGAAGTTGATTGAAGAATATGAGCAGTCTAAAAAT
AAAGATACTGAACAGTTATATGGTGAATTGATCACTGCTAATATATATCGAATTAAGCAA
GGCGATAAAGAAGTGACGGCATTGAATTATTATACGAATGAAGAAGTTGTCATTCCTTTA
AATCCTACAAAATCCCCATCAGCAAATGCTCAATATTATTATAAACAATATAATCGTATG
AAAACGAGAGAACGTGAATTACAACATCAAATTCAATTGACGAAAGACAATATAGATTAT
TTTTCAACAATCGAACAACAATTACATCATATTTCTGTCCATGACATTGATGAAATTAGA
GATGAATTAGCAGAACAAGGCTTTATGAAACAGCGTAAAAATCAAACTAAGAAAAAGAAA
GCGCAGATTCAATTACAACATTATGTATCAACTGATGGCGACGATATATATGTTGGTAAG
AATAACAAGCAAAATGATTATTTAACAAATAAAAAAGCTAAAAAAACTCACACATGGTTA
CACACAAAAGATATTCCTGGTTCACATGTCGTTATATTTAATGATGCACCAAGTGATACG
ACAATCAAGGAAGCGGCTATGTTAGCAGGATACTTTTCAAAAGCTGGTAATTCTGGACAA
ATACCTGTTGATTATACATTAATTAAAAATGTGCATAAACCATCAGGTGCAAAGCCTGGG
TTTGTAACATATGACAATCAAAAAACTTTGTATGCTACACCTGATTATGAACTTATTCAA
AAAATGAAACAATCATAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SAOUHSC_01175
- symbol: SAOUHSC_01175
- description: fibrinogen-binding protein A-like protein
- length: 565
- theoretical pI: 9.17033
- theoretical MW: 65784
- GRAVY: -0.772212
⊟Function[edit | edit source]
- TIGRFAM:
- TheSEED :
- Fibronectin/fibrinogen-binding protein
- PFAM: H2TH (CL0303) FbpA; Fibronectin-binding protein A N-terminus (FbpA) (PF05833; HMM-score: 473.1)and 5 moreno clan defined DUF814; Domain of unknown function (DUF814) (PF05670; HMM-score: 91.8)Apolipoprotein; Apolipoprotein A1/A4/E domain (PF01442; HMM-score: 16)Tropomyosin-lke (CL0452) CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels (PF16526; HMM-score: 15.3)no clan defined GAT; GAT domain (PF03127; HMM-score: 14.2)HotDog (CL0050) YiiD_C; Putative thioesterase (yiiD_Cterm) (PF09500; HMM-score: 11.1)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 7.5
- Cytoplasmic Membrane Score: 1.15
- Cellwall Score: 0.62
- Extracellular Score: 0.73
- Internal Helices: 0
- LocateP: Intracellular
- Prediction by SwissProt Classification: Cytoplasmic
- Pathway Prediction: No pathway
- Intracellular possibility: 1
- Signal peptide possibility: -1
- N-terminally Anchored Score: 1
- Predicted Cleavage Site: No CleavageSite
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.002293
- TAT(Tat/SPI): 0.000215
- LIPO(Sec/SPII): 0.001228
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MAYDGLFTKKMVESLQFLTTGRVHKINQPDNDTILMVVRQNRQNHQLLLSIHPNFSRLQLTTKKYDNPFNPPMFARVFRKHLEGGIIESIKQIGNDRRIEIDIKSKDEIGDTIYRTVILEIMGKHSNLILVDENRKIIEGFKHLTPNTNHYRTVMPGFNYEAPPTQHKINPYDITGAEVLKYIDFNAGNIAKQLLNQFEGFSPLITNEIVSRRQFMTSSTLPEAFDEVMAETKLPPTPIFHKNHETGKEDFYFIKLNQFNDDTVTYDSLNDLLDRFYDARGERERVKQRANDLVRFVQQQLHKYQNKLAKLIEEYEQSKNKDTEQLYGELITANIYRIKQGDKEVTALNYYTNEEVVIPLNPTKSPSANAQYYYKQYNRMKTRERELQHQIQLTKDNIDYFSTIEQQLHHISVHDIDEIRDELAEQGFMKQRKNQTKKKKAQIQLQHYVSTDGDDIYVGKNNKQNDYLTNKKAKKTHTWLHTKDIPGSHVVIFNDAPSDTTIKEAAMLAGYFSKAGNSGQIPVDYTLIKNVHKPSGAKPGFVTYDNQKTLYATPDYELIQKMKQS
⊟Experimental data[edit | edit source]
- experimentally validated: PeptideAtlas [1] [2]
- protein localization: data available for COL
- quantitative data / protein copy number per cell: data available for COL
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- MicrobesOnline: no polycistronic organisation predicted
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription pattern[edit | edit source]
- S.aureus Expression Data Browser: [3]
Multi-gene expression profiles
⊟Protein synthesis (provided by Aureolib)[edit | edit source]
- Aureolib: no data available
⊟Protein stability[edit | edit source]
- half-life: no data available
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Maren Depke, Stephan Michalik, Alexander Rabe, Kristin Surmann, Lars Brinkmann, Nico Jehmlich, Jörg Bernhardt, Michael Hecker, Bernd Wollscheid, Zhi Sun, Robert L Moritz, Uwe Völker, Frank Schmidt
A peptide resource for the analysis of Staphylococcus aureus in host-pathogen interaction studies.
Proteomics: 2015, 15(21);3648-61
[PubMed:26224020] [WorldCat.org] [DOI] (I p) - ↑ Stephan Michalik, Maren Depke, Annette Murr, Manuela Gesell Salazar, Ulrike Kusebauch, Zhi Sun, Tanja C Meyer, Kristin Surmann, Henrike Pförtner, Petra Hildebrandt, Stefan Weiss, Laura Marcela Palma Medina, Melanie Gutjahr, Elke Hammer, Dörte Becher, Thomas Pribyl, Sven Hammerschmidt, Eric W Deutsch, Samuel L Bader, Michael Hecker, Robert L Moritz, Ulrike Mäder, Uwe Völker, Frank Schmidt
A global Staphylococcus aureus proteome resource applied to the in vivo characterization of host-pathogen interactions.
Sci Rep: 2017, 7(1);9718
[PubMed:28887440] [WorldCat.org] [DOI] (I e) - ↑ Ulrike Mäder, Pierre Nicolas, Maren Depke, Jan Pané-Farré, Michel Debarbouille, Magdalena M van der Kooi-Pol, Cyprien Guérin, Sandra Dérozier, Aurelia Hiron, Hanne Jarmer, Aurélie Leduc, Stephan Michalik, Ewoud Reilman, Marc Schaffer, Frank Schmidt, Philippe Bessières, Philippe Noirot, Michael Hecker, Tarek Msadek, Uwe Völker, Jan Maarten van Dijl
Staphylococcus aureus Transcriptome Architecture: From Laboratory to Infection-Mimicking Conditions.
PLoS Genet: 2016, 12(4);e1005962
[PubMed:27035918] [WorldCat.org] [DOI] (I e)
⊟Relevant publications[edit | edit source]
Lionel Piroth, Yok-Ai Que, Eleonora Widmer, Alexandre Panchaud, Stéphane Piu, José M Entenza, Philippe Moreillon
The fibrinogen- and fibronectin-binding domains of Staphylococcus aureus fibronectin-binding protein A synergistically promote endothelial invasion and experimental endocarditis.
Infect Immun: 2008, 76(8);3824-31
[PubMed:18541660] [WorldCat.org] [DOI] (I p)