⊟Summary[edit | edit source]
- pan ID?: SAUPAN001199000
- symbol?: esaG1
- synonym: esaG
- description?: TIGR01741 family protein
- TIGR01741 family protein
- Repetitive hypothetical protein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 1470014..1480461
- synteny block?: BlockID0007130
- occurrence?: in 59% of 34 strains
essI (esaG) : tandem EssD nuclease immunity protein paralogue [1]
• There is a crystal structure for this specific paralogue : 8GUO
• This locus is highly prone to recombination leading to gene duplication / loss. Gene nomenclature is confusing and appears to be numbered sequentially by position in the genome and is not intended to show homology between strains (e.g. the first instance of essI/esaG in COL may have the greatest homology with the sixth instance in FPR3757 but the gene names would still be different [i.e. essI1/esaG1 and essI6/esaG6 in COL and FPR3757, respectively]). Likewise, pseudogenes are frequent and assigned gene nomenclature in this locus. As appropriate, please append a numeral to the gene names provided here consistent with the number of gene duplications in your genome of interest.
⊟Orthologs[edit | edit source]
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MTFEEKLSKIYNEIANEISSMIPVEWEKVYTMAYIDDGGGEVFFNYTKPGSDDLNYYTNI
N315 MTFEEKLSKIYNEIANEISNMIPVEWEKVYTMAYIDDGGGEVFFNYTKPGSDDLNYYTDI
NCTC8325 MTFEEKLSKIYNEIANEISSMIPVEWEKVYTMAYIDDGGGEVFFNYTKPGSDDLNYYTNI
Newman MTFEEKLSKIYNEIANEISSMIPVEWEKVYTMAYIDDGGGEVFFNYTKPGSDDLNYYTNI
USA300_FPR3757 MTFEEKLSKIYNEIANEISSMIPVEWEKVYTMAYIDDGGGEVFFNYTKPGSDDLNYYTNI
*******************.**************************************:*
COL PKEYNISVQVFDDLWMDLYDLFEELRDLFKEEDLEPWTSCEFDFTREGELKVSFDYIDWI
N315 PKEYNISVQVFDDLWMDLYDLFEELRDLFKEEDLEPWTSCEFDFTREGKLKVSFDYIDWI
NCTC8325 PKEYNISVQVFDDLWMDLYDLFEELRDLFKEEDLEPWTSCEFDFTREGELKVSFDYIDWI
Newman PKEYNISVQVFDDLWMDLYDLFEELRDLFKEEDLEPWTSCEFDFTREGELKVSFDYIDWI
USA300_FPR3757 PKEYNISVQVFDDLWMDLYDLFEELRDLFKEEDLEPWTSCEFDFTREGELKVSFDYIDWI
************************************************:***********
COL NSEFGQIGRQNYYKYRKFGILPETEYEINKVKEIEQYIKELEE
N315 NTEFDQLGRENYYMYKKFGVIPEMEYEMEEVKQIEQYIKEQEE
NCTC8325 NSEFGQIGRQNYYKYRKFGILPETEYEINKVKEIEQYIKELEE
Newman NSEFGQIGRQNYYKYRKFGILPETEYEINKVKEIEQYIKELEE
USA300_FPR3757 NSEFGQIGRQNYYKYRKFGILPETEYEINKVKEIEQYIKELEE
*:**.*:**:*** *:***::** ***:::**:******* **
- ↑ Ryan Jay Ohr, Mark Anderson, Miaomiao Shi, Olaf Schneewind, Dominique Missiakas
EssD, a Nuclease Effector of the Staphylococcus aureus ESS Pathway.
J Bacteriol: 2017, 199(1);
[PubMed:27795323] [WorldCat.org] [DOI] (I e)Stephen R Garrett, Giuseppina Mariano, Jo Dicks, Tracy Palmer
Homologous recombination between tandem paralogues drives evolution of a subset of type VII secretion system immunity genes in firmicute bacteria.
Microb Genom: 2022, 8(8);
[PubMed:35960642] [WorldCat.org] [DOI] (I p)