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PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

Summary[edit | edit source]

  • pan ID?: SAUPAN001199000
  • symbol?: esaG1
  • synonym: esaG
  • description?: TIGR01741 family protein

      descriptions from strain specific annotations:

    • TIGR01741 family protein
    • Repetitive hypothetical protein
  • strand?: +
  • coordinates?: 1470014..1480461
  • synteny block?: BlockID0007130
  • occurrence?: in 59% of 34 strains

essI (esaG) : tandem EssD nuclease immunity protein paralogue [1]

• There is a crystal structure for this specific paralogue : 8GUO

• This locus is highly prone to recombination leading to gene duplication / loss. Gene nomenclature is confusing and appears to be numbered sequentially by position in the genome and is not intended to show homology between strains (e.g. the first instance of essI/esaG in COL may have the greatest homology with the sixth instance in FPR3757 but the gene names would still be different [i.e. essI1/esaG1 and essI6/esaG6 in COL and FPR3757, respectively]). Likewise, pseudogenes are frequent and assigned gene nomenclature in this locus. As appropriate, please append a numeral to the gene names provided here consistent with the number of gene duplications in your genome of interest.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    SA2981_0293
    08BA02176:
    11819-97:
    MS7_0284
    6850:
    RSAU_000239
    71193:
    ECT-R 2:
    ECTR2_254
    ED133:
    ED98:
    SAAV_0261
    HO 5096 0412:
    JH1:
    SaurJH1_0284
    JH9:
    SaurJH9_0277
    JKD6008:
    JKD6159:
    JSNZ:
    JSNZ_000237
    LGA251:
    M013:
    MRSA252:
    MSHR1132:
    MSSA476:
    SAS0278
    Mu3:
    SAHV_0291
    Mu50:
    SAV0294
    MW2:
    MW0278
    RF122:
    ST398:
    T0131:
    TCH60:
    HMPREF0772_10202
    TW20:
    USA300_TCH1516:
    USA300HOU_0308
    VC40:
    SAVC_01220

Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MTFEEKLSKIYNEIANEISSMIPVEWEKVYTMAYIDDGGGEVFFNYTKPGSDDLNYYTNI
    N315            MTFEEKLSKIYNEIANEISNMIPVEWEKVYTMAYIDDGGGEVFFNYTKPGSDDLNYYTDI
    NCTC8325        MTFEEKLSKIYNEIANEISSMIPVEWEKVYTMAYIDDGGGEVFFNYTKPGSDDLNYYTNI
    Newman          MTFEEKLSKIYNEIANEISSMIPVEWEKVYTMAYIDDGGGEVFFNYTKPGSDDLNYYTNI
    USA300_FPR3757  MTFEEKLSKIYNEIANEISSMIPVEWEKVYTMAYIDDGGGEVFFNYTKPGSDDLNYYTNI
                    *******************.**************************************:*

    COL             PKEYNISVQVFDDLWMDLYDLFEELRDLFKEEDLEPWTSCEFDFTREGELKVSFDYIDWI
    N315            PKEYNISVQVFDDLWMDLYDLFEELRDLFKEEDLEPWTSCEFDFTREGKLKVSFDYIDWI
    NCTC8325        PKEYNISVQVFDDLWMDLYDLFEELRDLFKEEDLEPWTSCEFDFTREGELKVSFDYIDWI
    Newman          PKEYNISVQVFDDLWMDLYDLFEELRDLFKEEDLEPWTSCEFDFTREGELKVSFDYIDWI
    USA300_FPR3757  PKEYNISVQVFDDLWMDLYDLFEELRDLFKEEDLEPWTSCEFDFTREGELKVSFDYIDWI
                    ************************************************:***********

    COL             NSEFGQIGRQNYYKYRKFGILPETEYEINKVKEIEQYIKELEE
    N315            NTEFDQLGRENYYMYKKFGVIPEMEYEMEEVKQIEQYIKEQEE
    NCTC8325        NSEFGQIGRQNYYKYRKFGILPETEYEINKVKEIEQYIKELEE
    Newman          NSEFGQIGRQNYYKYRKFGILPETEYEINKVKEIEQYIKELEE
    USA300_FPR3757  NSEFGQIGRQNYYKYRKFGILPETEYEINKVKEIEQYIKELEE
                    *:**.*:**:*** *:***::** ***:::**:******* **

  1. Ryan Jay Ohr, Mark Anderson, Miaomiao Shi, Olaf Schneewind, Dominique Missiakas
    EssD, a Nuclease Effector of the Staphylococcus aureus ESS Pathway.
    J Bacteriol: 2017, 199(1);
    [PubMed:27795323] [WorldCat.org] [DOI] (I e)
    Stephen R Garrett, Giuseppina Mariano, Jo Dicks, Tracy Palmer
    Homologous recombination between tandem paralogues drives evolution of a subset of type VII secretion system immunity genes in firmicute bacteria.
    Microb Genom: 2022, 8(8);
    [PubMed:35960642] [WorldCat.org] [DOI] (I p)