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⊟Summary[edit | edit source]
- pan ID?: SAUPAN002205000
- symbol?: rrlA
- synonym:
- description?: 23S ribosomal RNA
- strand?: +
- coordinates?: 2708961..2711795
- synteny block?: BlockID0015060
- occurrence?: in 94% of 34 strains
rrlA : 23S ribosomal RNA
• A crystal structure is available : 6YEF
Possible posttranslational modifications: [1]
| Position | Original Residue | Modification | Location in Ribosome | Enzyme | Reason for Modification |
|---|---|---|---|---|---|
| 792 | uridine | (5)-methyluridine | RlmCD | ||
| 1947 | cytidine | O (2')-methylcytidine | Intersubunit bridge | Virulence Factor-Related | |
| 1942 | uridine | N (3)-methylpseudouridine | Subunit Interface | RlmH, RluD | |
| 1966 | uridine | C (5)-methyluridine | Peptidyl Transfer Center, A-site | RlmCD | Stabilizes growth rate |
| 2278 | guanosine | O (2')-methylguanosine | Peptidyl Transfer Center, P-site | RlmB | Universally-conserved modification |
| 2472 | guanosine | N (2)-methylguanosine | Peptidyl Transfer Center | RlmK | Increases growth rate |
| 2476 | uridine | dihydrouridine | |||
| 2525 | cytidine | O (2')-methylcytidine | Peptidyl Transfer Center | RlmM | |
| 2530 | adenosine | C (2')-methyladenosine | Peptidyl Transfer Center, A-site | RlmN | Universally-conserved modification |
| 2530 | adenosine | C (8)-methyladenosine | Peptidyl Transfer Center, A-site | Cfr | Confers resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins and streptogramin A |
| 2601 | guanosine | N (7)-methylguanosine | Helix 90 | RlmQ | Virulence Factor-Related |
⊟Orthologs[edit | edit source]
04-02981:
SA2981_rRNA02
08BA02176:
C248_0533
11819-97:
MS7_0456
6850:
RSAU_000416
71193:
ST398NM01_r063
ECT-R 2:
ECTR2_419
ED133:
SAOV_0500
ED98:
SAAV_0425a
HO 5096 0412:
SAEMRSA15_rRNA0002
JH1:
SaurJH1_R0006
JH9:
SaurJH9_R0006
JKD6008:
SAA6008_r02
JKD6159:
SAA6159_r02
JSNZ:
JSNZ_000418
LGA251:
—
M013:
M013TW_0448
MRSA252:
SARr002
MSHR1132:
SAMSHR1132_r02
MSSA476:
SASr002
Mu3:
SAHV_r0002
Mu50:
SAVrRNA02
MW2:
MWrRNA02
RF122:
SAB_r02
ST398:
—
T0131:
SAT0131_r002
TCH60:
HMPREF0772_r10006
TW20:
SATW20_r020
USA300_TCH1516:
USA300HOU_r0002 (rrl1)
VC40:
SAVC_r12611
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues:
- ↑ Alexander Golubev, Bulat Fatkhullin, Iskander Khusainov, Lasse Jenner, Azat Gabdulkhakov, Shamil Validov, Gulnara Yusupova, Marat Yusupov, Konstantin Usachev
Cryo-EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 Å resolution.
FEBS Lett: 2020, 594(21);3551-3567
[PubMed:32852796] [WorldCat.org] [DOI] (I p)Adrián González-López, Daniel S D Larsson, Ravi Kiran Koripella, Brett N Cain, Martin Garcia Chavez, Paul J Hergenrother, Suparna Sanyal, Maria Selmer
Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane.
Sci Rep: 2024, 14(1);14253
[PubMed:38902339] [WorldCat.org] [DOI] (I e)Roberto Bahena-Ceron, Chloé Teixeira, Jose R Jaramillo Ponce, Philippe Wolff, Florence Couzon, Pauline François, Bruno P Klaholz, François Vandenesch, Pascale Romby, Karen Moreau, Stefano Marzi
RlmQ: a newly discovered rRNA modification enzyme bridging RNA modification and virulence traits in Staphylococcus aureus.
RNA: 2024, 30(3);200-212
[PubMed:38164596] [WorldCat.org] [DOI] (I e)