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PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

Summary[edit | edit source]

  • pan ID?: SAUPAN002844000
  • symbol?:
  • synonym:
  • description?: pathogenicity island protein

      descriptions from strain specific annotations:

    • pathogenicity island protein
    • phage protein
  • strand?: -
  • coordinates?: 3296040..3297445
  • synteny block?: BlockID0020280
  • occurrence?: in 15% of 34 strains

immA (cip) : satellite pathogenicity island ImmR-degrading endopeptidase ImmA [1]

The staphylococcal satellite pathogenicity island ImmA-ImmR-Str' regulatory switch is the functional equivalent of the cip-cI*-cro system from staphylococcal prophage. Initial displacement of ImmR from its operators requires binding by one of the SIS inducers to ImmR. This alone leads to partial induction of both leftward and rightward transcription with further partial-induction due to ImmA sequestration of full-length ImmR and complete induction by ImmA proteolysis of ImmR. ImmA cleaves the master transcriptional repressor ImmR after the second alanine in the heptapeptide sequence: TIAAHFD. This typically creates a new ImmR C-terminus of alanine-82 resulting in full induction of the lytic phase.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    08BA02176:
    11819-97:
    6850:
    71193:
    ECT-R 2:
    ED133:
    ED98:
    HO 5096 0412:
    JH1:
    JH9:
    JKD6008:
    JKD6159:
    JSNZ:
    LGA251:
    M013:
    M013TW_0810
    MRSA252:
    MSHR1132:
    MSSA476:
    Mu3:
    Mu50:
    MW2:
    RF122:
    ST398:
    T0131:
    SAT0131_00919
    TCH60:
    TW20:
    USA300_TCH1516:
    USA300HOU_0853
    VC40:

Genome Viewer[edit | edit source]

COL
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MYLYEKMVIENKEIPIDDGKSLGNFEGLYDNGVILINKNLSERRKAEVLYEELAHHKLTY
    USA300_FPR3757  MYLYEKMVIENKEIPIDDGKSLGNFEGLYDNGVILINKNLSETRKAEVLYEELAHHKLTY
                    ****************************************** *****************

    COL             GNILDQSKFNNRKFENYARRHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEA
    USA300_FPR3757  GNILDQSKWINRKFENYARRHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEKYILEA
                    ********: ********************************************:*****

    COL             IEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
    USA300_FPR3757  IEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
                    ********************************

  1. Jennifer M Auchtung, Catherine A Lee, Katherine L Garrison, Alan D Grossman
    Identification and characterization of the immunity repressor (ImmR) that controls the mobile genetic element ICEBs1 of Bacillus subtilis.
    Mol Microbiol: 2007, 64(6);1515-28
    [PubMed:17511812] [WorldCat.org] [DOI] (P p)
    Baundauna Bose, Jennifer M Auchtung, Catherine A Lee, Alan D Grossman
    A conserved anti-repressor controls horizontal gene transfer by proteolysis.
    Mol Microbiol: 2008, 70(3);570-82
    [PubMed:18761623] [WorldCat.org] [DOI] (I p)
    Tal Argov, Shai Ran Sapir, Anna Pasechnek, Gil Azulay, Olga Stadnyuk, Lev Rabinovich, Nadejda Sigal, Ilya Borovok, Anat A Herskovits
    Coordination of cohabiting phage elements supports bacteria-phage cooperation.
    Nat Commun: 2019, 10(1);5288
    [PubMed:31754112] [WorldCat.org] [DOI] (I e)